[논문]The Effectiveness of Acupuncture for Herpes Zoster: A Systematic Review and Meta-Analysis

Seong-Kyeong Choi; Jeong-Hyun Moon; Woo-Seok Jang; Jung-Eun Jang; Si-Hyun Park; Won-Suk Sung; Chan-Yung Jung; Byung-Kwan Seo; Seung-Deok Lee; Kyung-Ho Kim; Eun-Jung Kim

doi:10.13045/jar.2022.00416

The Effectiveness of Acupuncture for Herpes Zoster: A Systematic Review and Meta-Analysis 원문보기

Journal of acupuncture research, v.40 no.1, 2023년, pp.16 - 34

Seong-Kyeong Choi (Department of Acupuncture & Moxibustion, Dongguk University, Bundang Korean Medicine Hospital) , Jeong-Hyun Moon (Department of Acupuncture & Moxibustion, Dongguk University, Bundang Korean Medicine Hospital) , Woo-Seok Jang (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Korean Medicine Hospital) , Jung-Eun Jang (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Korean Medicine Hospital) , Si-Hyun Park (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Korean Medicine Hospital) , Won-Suk Sung (Department of Acupuncture & Moxibustion, Dongguk University, Bundang Korean Medicine Hospital) , Chan-Yung Jung (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Korean Medicine Hospital) , Byung-Kwan Seo (Department of Acupuncture & Moxibustion, Kyung Hee University Korean Medicine Hospital at Gangdong) , Seung-Deok Lee (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Korean Medicine Hospital) , Kyung-Ho Kim (Department of Acupuncture & Moxibustion, Dongguk University Ilsan Korean Medicine Hospital) , Eun-Jung Kim (Department of Acupuncture & Moxibustion, Dongguk Univ)

Abstract ▼ AI-Helper

Herpes zoster (HZ) results from the reactivation of a varicella-zoster virus infection and is accompanied by moderate-to-severe pain in most patients. The most common treatment is medication; however, there are still limitations. Acupuncture reportedly has meaningful therapeutic effects and is a possible alternative option in HZ. However, no systematic reviews examining the use of acupuncture and electro-acupuncture (EA) alone have been published; in this study, we therefore aimed to systematically review those techniques. We searched for clinical trials of acupuncture and EA treatment for HZ up to October 2022. Trials that used acupuncture were included. Outcomes were visual analog scale (VAS) and effective rate. Secondary outcomes were time to pain relief, time to pain elimination, incrustation, decrustation, lastly incidence of post-herpetic neuralgia (PHN). In total, 22 randomized controlled trials were included in this research. Compared with conventional medication therapy, acupuncture was associated with a significant improvement in VAS, effective rate, and times to pain relief and elimination. Times to new blister cessation, incrustation, and decrustation (days) were significantly improved. Furthermore, the incidence rate of PHN was lower in acupuncture groups. The results suggest that acupuncture could be a reasonable treatment option for patients with HZ who suffer from pain and accompanying symptoms.

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표/그림 (13)

그림 Fig. 1. Flowchart of the study selection process. CNKI, China National Knowledge Infrastructure; KISS, Korean Studies Information Service System; KMBASE, Korean Medical Database; OASIS, Oriental Medicine Advanced Searching Integrated System; CiNii, Citation Information by NII.
표 Table 1. Characteristics of included studies
표 Table 1. Continued
그림 Fig. 2. Risk of bias summary and risk of bias graph: review authors’ judgments about each risk of bias item for each included study presented as percentages across all included studies.
그림 Fig. 3. Treatment effective rate. (A) Comparison of acupuncture treatment alone and Western medicine treatment. (B) Comparison of add-on acupuncture treatment (acupuncture + Western medicine) and Western medicine treatment. M-H, Mantel-Haenszel; CI, confidence interval.
그림 Fig. 4. Treatment visual analog scale for pain. (A) Comparison of acupuncture treatment alone and Western medicine treatment. (B) Comparison of add-on acupuncture treatment (acupuncture + Western medicine) and Western medicine treatment. SD, standard deviation; IV, weighted mean difference; CI, confidence interval.
그림 Fig. 5. Treatment time to pain relief (days). (A) Comparison of acupuncture treatment alone and Western medicine treatment. (B) Comparison of add-on acupuncture treatment (acupuncture + Western medicine) and Western medicine treatment. SD, standard deviation; IV, weighted mean difference; CI, confidence interval.
그림 Fig. 6. Treatment time to new blister cessation (days). (A) Comparison of acupuncture treatment alone and Western medicine treatment. (B) Comparison of add-on acupuncture treatment (acupuncture + Western medicine) and Western medicine treatment. SD, standard deviation; IV, weighted mean difference; CI, confidence interval.
그림 Fig. 7. Treatment time to incrustation (days). (A) Comparison of acupuncture treatment alone and Western medicine treatment. (B) Comparison of add-on acupuncture treatment (acupuncture + Western medicine) and Western medicine treatment. SD, standard deviation; IV, weighted mean difference; CI, confidence interval.
그림 Fig. 8. Treatment time to decrustation (days). (A) Comparison of acupuncture treatment alone and Western medicine treatment. (B) Comparison of add-on acupuncture treatment (acupuncture + Western medicine) and Western medicine treatment. SD, standard deviation; IV, mean weighted difference; CI, confidence interval.
그림 Fig. 9. Incidence of post-herpetic neuralgia. (A) Comparison of acupuncture treatment alone and Western medicine treatment. (B) Comparison of add-on acupuncture treatment (acupuncture + Western medicine) and Western medicine treatment. M-H, Mantel- Haenszel; CI, confidence interval.
그림 Fig. 10. Incidence of adverse events. M–H, Mantel–Haenszel; CI, confidence interval.
표 Table 2. Sensitivity analysis of visual analog scale for pain in treatment with acupuncture alone

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