[논문]Effects of Taraxacum mongolicum Extract on Blood Glucose Levels and Lipid Profiles in Streptozotocin-Induced Diabetic Rats

Hye Kyoung Han; Eun Young Choi

doi:10.9799/ksfan.2023.36.1.050

Effects of Taraxacum mongolicum Extract on Blood Glucose Levels and Lipid Profiles in Streptozotocin-Induced Diabetic Rats 원문보기

한국식품영양학회지 = The Korean journal of food and nutrition, v.36 no.1, 2023년, pp.50 - 57

Hye Kyoung Han (Dept. of Food and Nutrition, KyungBuk College) , Eun Young Choi (Dept. of Food and Nutrition, Bucheon University)

Abstract ▼ AI-Helper

This study was designed to evaluate antihyperglycemic and antihyperlipidemic effects of ethanol extracts of Taraxacum mongolicum(T.m.) on streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley rats were randomly assigned to five groups: normal (NC), STZ-control (DC), and three experimental groups. Diabetes was induced in Sprague-Dawley rats with a single intravenous injection [45 mg/kg body weight (b.w.)] of STZ. An ethanol extract of T.m. was orally given to diabetic rats for 14 days. Three experimental groups were additionally treated with T.m. extract at doses of 1 g/kg b.w./day for T.m.-1, 2 g/kg b.w./day for T.m.-2, and 3 g/kg b.w./day for T.m.-3. Oral administration of T.m.-2 significantly increased their body weights. T.m.-1 and T.m.-2 significantly decreased aspartate aminotransferase (AST) levels than DC. T.m.-1 and T.m.-2 group significantly decreased blood glucose levels. Total cholesterol, triglycerides, and free fatty acids were significantly decreased whereas high-density lipoprotein cholesterol was significantly increased in groups treated with T.m. extract than those in the DC group. These results support the fact that administration of T.m. extract can reduce hyperglycemia and hyperlipidemia risk in diabetic rats.

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표/그림 (7)

표 Table 1. Composition of AIN-93 diets (g/kg diet)
표 Table 2. Initial and final body weight of normal and diabetic rats fed extract of Taraxacum mongolicum¹⁾
표 Table 3. Food intake and food efficiency ratio (FER) of normal and diabetic rats fed extract of Taraxacum mongolicum¹⁾
표 Table 4. Hematocrit levels and aminotransferase activities of normal and diabetic rats fed extract of Taraxacum mongolicum¹⁾
표 Table 5. Plasma glucose levels of normal and diabetic rats fed extract of Taraxacum mongolicum¹⁾ (mg/dL)
표 Table 6. Plasma cholesterol levels of normal and diabetic rats fed extract of Taraxacum mongolicum¹⁾ (mg/dL)
표 Table 7. Levels of triglyceride (TG), HDL-cholesterol (HDL-chol) and free fatty acid (FFA) in plasma of normal and diabetic rats fed extract of Taraxacum mongolicum¹⁾

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