[논문]전산해석을 통한 전대뇌동맥류 코일 색전술 후 혈류 유동 분석

김동휘; 윤정훈; 이창용; 제준우; 김동민; 배영오; 황진율

doi:10.5407/jksv.2023.21.1.080

전산해석을 통한 전대뇌동맥류 코일 색전술 후 혈류 유동 분석
Analysis of Blood Flow after Coil Embolization in Anterior Cerebral Artery Aneurysm 원문보기

한국가시화정보학회지= Journal of the Korean society of visualization, v.21 no.1, 2023년, pp.80 - 93

김동휘 (School of Mechanical Engineering, Pusan National University) , 윤정훈 (School of Mechanical Engineering, Pusan National University) , 이창용 (School of Mechanical Engineering, Pusan National University) , 제준우 (School of Mechanical Engineering, Pusan National University) , 김동민 (School of Mechanical Engineering, Pusan National University) , 배영오 (School of Mechanical Engineering, Pusan National University) , 황진율 (School of Mechanical Engineering, Pusan National University)

Abstract ▼ AI-Helper

We performed numerical simulations of blood flow in an arterial cerebral artery aneurysm to investigate the hemodynamic behavior after coil embolization. A patient-specific model was created based on CTA data. We also conducted the coil embolization simulation to obtain the coil placement within the aneurysm. Blood was assumed to be an incompressible Newtonian fluid, and both the vessel and coil were considered rigid walls. The pulsatile boundary condition was applied at the inlet, and the outflow boundary conditions were used at the outlets. Our findings demonstrated that the coil embolization significantly reduces the blood volume flowrate entering the aneurysm by effectively blocking the inflow jet, leading to a decrease in both TAWSS and WSS, especially at the systolic peak in the impingement zone. While several high OSI regions disappeared over the aneurysm surface, we observed high OSI regions with a relatively small area where the coil did not completely occlude the aneurysm. Overall, these results quantitatively analyzed the effectiveness of coil embolization by focusing on hemodynamic indicators, potentially preventing aneurysm rupture. The present work could contribute to the development of patient-specific coil embolization.

주제어

표/그림 (11)

그림 Fig. 1. Schematic of cerebral aneurysm and coil embolization. (a) Cerebral aneurysm that shows the abnormal bulging of the arterial wall. (b) Coil embolization of the cerebral aneurysm. The grey shading denotes the placement of coils within the aneurysm to block blood flow.
그림 Fig. 2. Vascular model created from patient CTA data. (a) Lateral view of the patient's CTA image, highlighting the aneurysm in red. (b) The created vascular model (blue isosurface) overlaid with the 3D image. (c) Front view of the vascular model, illustrating the anatomy of the patient's blood vessels and aneurysm. (d) Side view of the vascular model with the location of the neck plane defined in the present study.
그림 Fig. 3. Coil embolization simulation. (a) A coil and cross-sectional view of the coil, illustrating initial shape and dimensions. (b) Insertion of the catheter into the aneurysm at a tilt angle of 15° to the neck plane. (c,d) Placement of the coil within the aneurysm after coil embolization; (c) front view and (d) side view.
그림 Fig. 4. Aneurysm models. (a,c) Surface mesh and (b,d) volume mesh of the aneurysm models. (a,b) Aneurysm model without coil (AM). (c,d) Aneurysm model after coil embolization (AMC). Here, the orange area denotes the cross-section of the coil.
그림 Fig. 5. Pulsatile flowrate profile applied at the inlet.
표 Table 1. Reynolds number at the inlet.
그림 Fig. 6. Streamline patterns colored by the magnitude of the velocity at the systolic peak; (a) AM and (b) AMC.
그림 Fig. 7. Variations of the flowrate into the aneurysm dome across the neck plane; AM (blue) and AMC (orange).
그림 Fig. 8. Contours of TAWSS for (a) AM and (b)AMC. The inserted arrows highlight the impingementzone and bifurcation zone. (c) Histogram of thedome area with respect to the magnitude ofTAWSS; AM (blue) and AMC (orange). Here, thehistogram is normalized by the dome area.
그림 Fig. 9. Contours of OSI for (a) AM and (b) AMC. (c) Histogram of the dome area with respect to the magnitude of OSI; AM (blue) and AMC (orange). Here, the histogram is normalized by the dome area.
그림 Fig. 10. Contours of the WSS magnitude at the peak systole for (a) AM and (b) AMC. The inserted arrows highlight the impingement zone and bifurcation zone. (c) Histogram of the dome area with respect to the WSS magnitude; AM (blue) and AMC (orange). Here, the histogram is normalized by the dome area.

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표제어: PCR

동의어: Packet Collision Rate

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