[논문]네트워크 약리학을 기반으로한 총명공진단(聰明供辰丹) 구성성분과 알츠하이머 타겟 유전자의 효능 및 작용기전 예측

권빛나; 유수민; 김동욱; 오진영; 장미경; 박성주; 배기상

doi:10.13048/jkm.23019

네트워크 약리학을 기반으로한 총명공진단(聰明供辰丹) 구성성분과 알츠하이머 타겟 유전자의 효능 및 작용기전 예측
Network pharmacology-based prediction of efficacy and mechanism of Chongmyunggongjin-dan acting on Alzheimer's disease 원문보기

Journal of Korean Medicine = 대한한의학회지, v.44 no.2, 2023년, pp.106 - 118

권빛나 (원광대학교 한의과대학 약리학교실) , 유수민 (원광대학교 한의과대학 약리학교실) , 김동욱 (원광대학교 한의과대학 약리학교실) , 오진영 (원광대학교 한의과대학 약리학교실) , 장미경 (원광대학교 한의과대학 약리학교실) , 박성주 (원광대학교 한방심신증후군연구센터) , 배기상 (원광대학교 한의과대학 약리학교실)

Abstract ▼ AI-Helper

Objectives: Network pharmacology is a method of constructing and analyzing a drug-compound-target network to predict potential efficacy and mechanisms related to drug targets. In that large-scale analysis can be performed in a short time, it is considered a suitable tool to explore the function and role of herbal medicine. Thus, we investigated the potential functions and pathways of Chongmyunggongjin-dan (CMGJD) on Alzheimer's disease (AD) via network pharmacology analysis. Methods: Using public databases and PubChem database, compounds of CMGJD and their target genes were collected. The putative target genes of CMGJD and known target genes of AD were compared and found the correlation. Then, the network was constructed using Cytoscape 3.9.1. and functional enrichment analysis was conducted based on the Gene Ontology (GO) Biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms. Results: The result showed that total 104 compounds and 1157 related genes were gathered from CMGJD. The network consisted of 1157nodes and 10034 edges. 859 genes were interacted with AD gene set, suggesting that the effects of CMGJD are closely related to AD. Target genes of CMGJD are considerably associated with various pathways including 'Positive regulation of chemokine production', 'Cellular response to toxic substance', 'Arachidonic acid metabolic process', 'PI3K-Akt signaling pathway', 'Metabolic pathways', 'IL-17 signaling pathway' and 'Neuroactive ligand-receptor interaction'. Conclusion: Through a network pharmacological method, CMGJD was predicted to have high relevance with AD by regulating inflammation. This study could be used as a basis for effects of CMGJD on AD.

주제어

표/그림 (6)

표 Table 1. List of the compounds from Chongmyunggongjin-dan with the Pubchem ID
표 Table 1. List of the compounds from Chongmyunggongjin-dan with the Pubchem ID (Ccontinue)
그림 Fig. 1. (A) Network of CMGJD with 1157nodes and 10034edges. (B) Veen diagram of intersection targets between CMGJD and the gene sets of Alzheimer's disease. (C) Network of common genes of CMGJD and Alzheimer's disease.
표 Table 2. List of the common genes of Chongmyunggongjin-dan and Alzheimer's disease gene sets.
그림 Fig. 2. Biological processes related to targets of CMGJD using GO Biological process database.
그림 Fig. 3. Biological processes related to targets of CMGJD using KEGG Pathways database.

참고문헌 (36)

Zhang, R.Zhu, X.Bai, H. & Ning, K. (2019).？Network pharmacology databases for traditional？chinese medicine: Review and assessment. Front Pharmacol. 10(123. 10.3389/fphar.2019.00123

상세보기
Talevi, A. (2015). Multi-target pharmacology:？Possibilities and limitations of the "skeleton？key approach" from a medicinal chemist？perspective. Frontiers in pharmacology. 6(205).
Shao, L. & Zhang, B. (2013). Traditional？chinese medicine network pharmacology: Theory,？methodology and application. Chinese journal？of natural medicines. 11(2). 110-120.
Corson, T. W. & Crews, C. M. (2007). Molecular？understanding and modern application of？traditional medicines: Triumphs and trials.？Cell. 130(5). 769-774. 10.1016/j.cell.2007.08.021

상세보기
Kim, M. H. (2023). Prediction of functional？molecular machanism of astragalus membranaceus？on obesity via network pharmacology analysis.？The Korea Journal of Herbology. 38(1). 45-53.
Lee, W. Y.Lee, C. Y.Kim, Y. S. & Kim, C. E.？(2019). The methodological trends of traditional？herbal medicine employing network pharmacology.？Biomolecules. 9(8). 10.3390/biom9080362

상세보기
Hopkins, A. L. (2008). Network pharmacology:？The next paradigm in drug discovery. Nat Chem？Biol. 4(11). 682-690. 10.1038/nchembio.118

상세보기
Lee, W. Y.Kim, C. E. & Lee, C. Y. (2021). A？novel method to investigating korean medicine？theory: Drug-centered approach employing？network pharmacology. Journal of Physiology？& Pathology in Korean Medicine. 35(5).？125-131.
Hwang, G.-s. & Shin, Y.-j. (2020). Protective？effects of chongmyunggongjin-dan on h 2 o？2-induced c6 glial cell death. The Journal of？Internal Korean Medicine. 41(1). 44-58.
Lee, J.-H., Jo, D.-C., Kim, C.-G., Moon, S.-J.,？Park, T.-Y., Ko, Y.-S., et al. (2013). A？literature review of effectiveness on the？gongjin-dan (gongchen-dan). Journal of Korean？Medicine Rehabilitation. 23(3). 69-78.
Committee, O. M. T. E. (2015). Oriental herbal？medicine (version 2). Shinilbooks.
Park, E.-k.Shim, E.-s.Jung, H.-s.Sohn, N.-w. &？Sohn, Y.-j. (2008). Effects of chongmyung-tang,？polygalae radix and acori graminei rhizoma on？aβ toxicity and memory dysfunction in mice.？The journal of Internal Korean Medicine.？29(3). 608-620.
Jang, H.-J., Sung, W.-Y., Lee, S.-H., Son,？J.-H., Han, S.-H. & Jung, H.-C. (2004). A？study of gongjin-dan in patients with mild？dementia of alzheimer type. Journal of Oriental？Neuropsychiatry. 15(2). 141-148.
Baek, M. S., Kim, H. K., Han, K., Kwon, H.？S., Na, H. K., Lyoo, C. H., et al. (2022).？Annual trends in the incidence and prevalence？of alzheimer's disease in south korea: A？nationwide cohort study. Front Neurol.？13(883549. 10.3389/fneur.2022.883549

상세보기
Li, X., Feng, X., Sun, X., Hou, N., Han, F. &？Liu, Y. (2022). Global, regional, and national？burden of alzheimer's disease and other？dementias, 1990-2019. Front Aging Neurosci.？14(937486. 10.3389/fnagi.2022.937486

상세보기
Silva, M. V. F., Loures, C. M. G., Alves, L. C.？V., de Souza, L. C., Borges, K. B. G. & Carvalho,？M. D. G. (2019). Alzheimer's disease: Risk？factors and potentially protective measures. J？Biomed Sci. 26(1). 33. 10.1186/s12929-019-0524-y

상세보기
Kang, H. & Park, K. W. (2015). Recent update？of clinical drug trials in alzheimer's disease. Journal of the Korean Neurological Association.？33(4). 252-258.

상세보기
Hardy, J. & Selkoe, D. J. (2002). The amyloid？hypothesis of alzheimer's disease: Progress and？problems on the road to therapeutics. Science.？297(5580). 353-356. 10.1126/science.1072994

상세보기
Binder, L. I.Guillozet-Bongaarts, A. L.Garcia？-Sierra, F. & Berry, R. W. (2005). Tau, tangles,？and alzheimer's disease. Biochim Biophys？Acta. 1739(2-3). 216-223. 10.1016/j.bbadis.2004.08.014

상세보기
Princiotta Cariddi, L.Mauri, M.Cosentino,？M.Versino, M. & Marino, F. (2022). Alzheimer's？disease: From immune homeostasis to？neuroinflammatory condition. International？Journal of Molecular Sciences. 23(21). 13008.

상세보기
Zuena, A. R.Casolini, P.Lattanzi, R. & Maftei,？D. (2019). Chemokines in alzheimer's disease:？New insights into prokineticins, chemokine-like？proteins. Frontiers in pharmacology. 10(622.
Nisa, F. Y., Rahman, M. A., Hossen, M. A.,？Khan, M. F., Khan, M. A. N., Majid, M., et al.？(2021). Role of neurotoxicants in the pathogenesis？of alzheimer's disease: A mechanistic insight.？Ann Med. 53(1). 1476-1501. 10.1080/07853890.2021.1966088

상세보기
Thomas, M. H. & Olivier, J. L. (2016).？Arachidonic acid in alzheimer's disease.？Journal of Neurology & Neuromedicine. 1(9).
Deng, X., Zhao, S., Liu, X., Han, L., Wang,？R., Hao, H., et al. (2020). Polygala tenuifolia:？A source for anti-alzheimer's disease drugs.？Pharm Biol. 58(1). 410-416. 10.1080/13880209.2020.1758732

상세보기
Cheong, M. H., Lee, S. R., Yoo, H. S., Jeong,？J. W., Kim, G. Y., Kim, W. J., et al. (2011).？Anti-inflammatory effects of polygala？tenuifolia root through inhibition of nf-kappab？activation in lipopolysaccharide-induced bv2？microglial cells. J Ethnopharmacol. 137(3).？1402-1408. 10.1016/j.jep.2011.08.008

상세보기
Jiang, J., Kim, J. J., Kim, D. Y., Kim, M. K.,？Oh, N. H., Koppula, S., et al. (2012). Acorus？gramineus inhibits microglia mediated？neuroinflammation and prevents neurotoxicity？in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine？(mptp)-induced mouse model of parkinson's？disease. J Ethnopharmacol. 144(3). 506-513.？10.1016/j.jep.2012.09.026

상세보기
Jeong, J. W., Lee, H. H., Han, M. H., Kim, G.？Y., Hong, S. H., Park, C., et al. (2014).？Ethanol extract of poria cocos reduces the？production of inflammatory mediators by？suppressing the nf-kappab signaling pathway？in lipopolysaccharide-stimulated raw 264.7？macrophages. BMC Complement Altern Med.？14(101. 10.1186/1472-6882-14-101

상세보기
Choi, J. G.Sim, Y.Kim, W.Kim, S. Y. & Oh,？M. S. (2015). Effect of hoelen cum radix on？learning and memory enhancement via？stimulation of neuronal differentiation in the？hippocampus of the mouse brain. The Korea？Journal of Herbology. 30(2). 43-48.
Xie, D., Deng, T., Zhai, Z., Qin, T., Song, C.,？Xu, Y., et al. (2023). Moschus exerted？protective activity against h2o2-induced cell？injury in pc12 cells through regulating？nrf-2/are signaling pathways. Biomedicine &？Pharmacotherapy. 159(114290.

상세보기
Park, Y.-H., Son, I. H., Kim, B., Lyu, Y.-S.,？Moon, H.-I. & Kang, H.-W. (2009). Poria？cocos water extract (pcw) protects pc1 2 neuronal cells from beta-amyloid-induced cell？death through antioxidant and antiapoptotic？functions. Die Pharmazie-An International？Journal of Pharmaceutical Sciences. 64(11).？760-764.
Wiatrak, B.Kubis-Kubiak, A.Piwowar, A. &？Barg, E. (2020). Pc12 cell line: Cell types,？coating of culture vessels, differentiation and？other culture conditions. Cells. 9(4). 10.3390/cells9040958

상세보기
Almohaimeed, H. M., Batawi, A. H.,？Mohammedsaleh, Z. M., Al Jaouni, S., Mutlq？Alsawat, S. A., Abd El Wahab, M. G., et al.？(2021). Musk (moschus moschiferus) attenuates？changes in main olfactory bulb of depressed？mice: Behavioral, biochemical, and histopathological？evidence. Front Behav Neurosci. 15(704180.？10.3389/fnbeh.2021.704180
Youn, K. & Jun, M. (2012). Inhibitory effects？of key compounds isolated from corni fructus？on bace1 activity. Phytother Res. 26(11).？1714-1718. 10.1002/ptr.4638

상세보기
Sung, Y. H., Chang, H. K., Kim, S. E., Kim,？Y. M., Seo, J. H., Shin, M. C., et al. (2009).？Anti-inflammatory and analgesic effects of the？aqueous extract of corni fructus in murine raw？264.7 macrophage cells. J Med Food. 12(4).？788-795. 10.1089/jmf.2008.1011

원문보기 상세보기
Lee, S. H., Yang, H. W., Ding, Y., Wang, Y.,？Jeon, Y. J., Moon, S. H., et al. (2015).？Anti-inflammatory effects of enzymatic？hydrolysates of velvet antler in raw 264.7 cells？in vitro and zebrafish model. EXCLI J.？14(1122-1132. 10.17179/excli2015-481

상세보기
Oh, Y. C.Jeong, Y. H.Li, W. & Go, Y. (2019).？Angelicae gigantis radix regulates lps-induced？neuroinflammation in bv2 microglia by？inhibiting nf-kappab and mapk activity and？inducing nrf-2 activity. Molecules. 24(20).？10.3390/molecules24203755？

상세보기

저자의 다른 논문 :

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증