[논문]마황성분 체중감량 한약제제가 심혈관계에 미치는 영향: 3차원 맥영상 검사 연구

강희정; 구태훈; 김경철

doi:10.15429/jkomor.2023.23.1.28

마황성분 체중감량 한약제제가 심혈관계에 미치는 영향: 3차원 맥영상 검사 연구
Hemodynamic Effects of Herbal Prescription Containing Ephedra on Weight Loss: A 3-Dimensional Radial Pulse Tonometry Device Study 원문보기

한방비만학회지 = Journal of Korean Medicine for Obesity Research, v.23 no.1, 2023년, pp.28 - 41

강희정 (동의대학교 한의과대학) , 구태훈 (옥천당(주)) , 김경철 (동의대학교 한의과대학)

Abstract ▼ AI-Helper

Objectives: This study was aimed to evaluate the hemodynamic feasibility using pulse parameters as a way to establish safe dose guidelines for herbal prescription containing Ephedra herb (Ephedra intermedia Schrenk & C.A.Mey) on weight loss, and to provide a foundation for developing evidence-based guidelines for clinical use. Methods: Forty-two volunteers were recruited to participate in a study examining the changes in pulse wave characteristics following the ingestion of Gambi-hwan, a herbal prescription containing ephedra, over a period of 4 weeks, and pulse wave measurements were taken before and after the administration. Pulse wave parameters were measured in this study using a 3-dimensional radial pulse tonometry device (DMP-Lifeplus). In addition, questionnaire, blood pressure, temperature, and body composition were also measured as secondary measures. Results: Fifteen minutes after administration of Gambi-hwan, the non-adverse event group (non-AE) exhibited a statistically significant increase in several power and pressure-related parameters, including h1, h5, systolic area, pulse area, and pulse width, while the AE group showed a trend of decreasing stroke volume and increasing Radial Augmentation Index (RAI), w, and w/t. After 4 weeks of administration, both groups exhibited significant changes in pulse rate, w/t, RAI, t3/t, stroke volume (SV), and stroke volume Index (SVI). Notably, there are significant differences between AE group and non-AE group in w/t, SV, and SVI. Conclusions: These findings suggest that pulse parameters may be a useful way to establish safe dosing guidelines for weight loss herbal prescription containing ephedra. Further research is needed to confirm these results and to develop evidence-based guidelines for clinical use.

주제어

표/그림 (17)

그림 Fig. 1. Manufacturing processing for keep constant ephedrine content.
그림 Fig. 2. Three-dimensional tonometric radial pulse analyzer (DMP-Lifeplus).
표 Table 1. Recipes of Gambi-Hwan
그림 Fig. 3. Standard radial pulse waveform.
그림 Fig. 4. Protocol of clinical study.
표 Table 2. Descriptive Statistics of Participants
표 Table 3. Compare Table of Pulse Parameter Between Baseline and Immediate Observation in Non-AE Group
표 Table 3. Continued
표 Table 4. Compare Table of Pulse Parameter Between Baseline and Immediate Observation in AE Group
그림 Fig. 5. Box-plot of immediate change parameter of non-adverse event (AE) group. In non-AE group, power and pressure related pulse parameter showed significant increase after ingestions of Gambi-hwan. RAI: Radial Augmentation Index.
그림 Fig. 6. Box-plot of immediate change parameter of adverse event (AE) group. In AE group, blood vessel stiffness related pulse parameter showed trend of increase after ingestions of Gambee-hwan, while stroke volume (SV) has trend of decrease.
표 Table 5. Compare Table of Physiological Parameter Between Baseline and 2 Weeks, 4 Weeks After of Non-AE Group
표 Table 6. Compare Table of Physiological Parameter Between Baseline and 2 Weeks, 4 Weeks After in AE Group
그림 Fig. 7. Box-plot of 2 weeks and 4 weeks change parameter of non-adverse event (AE) group. In non-AE group, loss of blood vessel compliance related parameter (w/t) and pulse rate showed significant increase after 4 weeks ingestions of Gambi-hwan, while heart valve pulse peak has trend of decrease. RAI: Radial Augmentation Index.
표 Table 6. Continued
그림 Fig. 8. Box-plot of 2 weeks and 4 weeks change parameter of adverse event (AE) group. In AE group, loss of blood vessel compliance related parameter (w/t) showed significant increase after 4 weeks ingestions of Gambi-hwan, while stroke volume (SV) showed significant decrease.
표 Table 7. Specific Parameter Which Has Differency Between AE Group and Non-AE Group

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