[논문]고수 에탄올 추출물의 고지방식이 비만 동물모델에서의 항비만효과

이락원; 강순아

doi:10.9799/ksfan.2023.36.4.296

고수 에탄올 추출물의 고지방식이 비만 동물모델에서의 항비만효과
Ant-Obesity Effect of Coriandrum sativum L. Ethanol Extract in High Fat-Induced Obesity Animal Model 원문보기

한국식품영양학회지 = The Korean journal of food and nutrition, v.36 no.4, 2023년, pp.296 - 308

이락원 (호서대학교 보건산업연구소) , 강순아 (호서대학교 벤처대학원 융합공학과)

Abstract ▼ AI-Helper

This study investigated the anti-obesity effects of Coriandrum sativum L. ethanol extracts in a high fat diet-induced obesity model (DIO). We confirmed the anti-obesity effects by analysing the expression of the related proteins, weight gain, dietary intake, dietary efficiency, blood biochemistry, histological analysis and western blot analysis. After oral administration of Coriandrum sativumL. ethanol extracts at concentrations of 250 and 500 mg/kg, a significant improvement in dietary efficiency, reduction in weight gain, triglycerides, total cholesterol and LDL-cholesterol in blood lipid was observed for 8 weeks. In addition, improvement in blood glucose and metabolism confirmed through glucose tolerance test was observed. Further, the concentration of alanine transaminase (ALT) in blood was significantly decreased, which improved the fatty liver caused by high-fat diet intake as confirmed by liver tissue analysis. This phenomenon was confirmed to decrease the expression of fat accumulation-related PPARγ and FAS protein in the liver tissue. Especially, it is believed that FAS, a liposynthetic enzyme, has a stronger inhibitory effect than PPARγ. Therefore, Coriandrum sativum L. ethanol extract is thought to improve obesity by reducing blood lipids levels, improving glucose metabolism and inhibiting synthesis of the fat that accumulates in the liver in high-fat diet-induced obesity animal models.

주제어

표/그림 (9)

표 Table 1. Change of body weight among groups
그림 Fig. 1. Fat tissue weight changes in diet-induced obesity model. Each value represents the mean±S.D. *Significantly different from CON vs DIO (p<0.05). ^a-cMeans indicated with different letters are significantly different among DIO groups at p<0.05 by Duncan's multiple range test. CON: normal control, DIO: high-fat diet induced obesity animal, CE:oral administration of Coriandrum sativum L. ethanol extract 250mg/kg or 500 mg/kg.
표 Table 2. Change of food intake and food efficiency ratio (FER) among groups
그림 Fig. 2. Organ weight changes in diet-induced obesity model. Each value represents the mean±S.D. *Significantly different from CON vs DIO (p<0.05). ^a,bMeans indicated with different letters are significantly different among DIO groups at p<0.05 by Duncan's multiple range test. CON: normal control, DIO: high-fat diet induced obesity animal, CE:oral administration of Coriandrum sativum L. ethanol extract 250mg/kg or 500 mg/kg.
그림 Fig. 3. Blood lipid profiles changes in diet-induced obesity model. Each value represents the mean±S.D. *Significantly different from CON vs DIO (p<0.05). ^a,bMeans indicated with different letters are significantly different among DIO groups at p<0.05 by Duncan's multiple range test. CON: normal control, DIO: high-fat diet induced obesity animal, CE: oral administration of Coriandrum sativum L. ethanol extract 250 mg/kg or 500 mg/kg.
그림 Fig. 4. Blood total protein, creatinine, and blood urea nitrogen changes in diet-induced obesity model. Each value represents the mean±S.D. CON: normal control, DIO: high-fat diet induced obesity animal, CE: oral administration of Coriandrum sativum L. ethanol extract 250 mg/kg or 500 mg/kg.
그림 Fig. 5. Blood ALT, AST, and LDH changes in diet-induced obesity model. Each value represents the mean±S.D. *Significantly different from CON vs DIO (p<0.05). ^a,bMeans indicated with different letters are significantly different among DIO groups at p<0.05 by Duncan's multiple range test. CON: normal control, DIO: high-fat diet induced obesity animal, CE: oral administration of Coriandrum sativum L. ethanol extract 250 mg/kg or 500 mg/kg.
그림 Fig. 6. Histological change of hepatic tissue(×100) (A), pancreatic tissue(×200) (B), epididymal fat tissue(×200) (B) by H&E stained.
그림 Fig. 7. PPARγ and FAS protein expression on diet-induced obesity model. *Significantly different from CON vs DIO (p<0.05). ^a-cMeans indicated with different letters are significantly different among DIO groups at p<0.05 by Duncan's multiple range test.

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동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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