[논문]작약감초탕 가 현호색의 항염증 기전에 대한 네트워크 약리학적 분석

김영식; 김홍준; 박한빈; 이승호

doi:10.14374/hfs.2024.32.1.39

작약감초탕 가 현호색의 항염증 기전에 대한 네트워크 약리학적 분석
Network pharmacology analysis of Jakyakgamchotang with corydalis tuber for anti-inflammation 원문보기

大韓韓醫學方劑學會誌 = Herbal formula science, v.32 no.1, 2024년, pp.39 - 49

김영식 (우석대학교 한의과대학 본초학교실) , 김홍준 (우석대학교 한의과대학 방제학교실) , 박한빈 (우석대학교 한의과대학 방제학교실) , 이승호 (우석대학교 한의과대학 병리학교실)

Abstract ▼ AI-Helper

Objectives : The purpose of this study was to investigate the molecular targets and pathways of anti-inflammatory effects of Jakyakgamchotang with corydalis tuber (JC) using network pharmacology. Methods : The compounds in constituent herbal medicines of JC were searched in TCM systems pharmacology (TCMSP). Target gene informations of the components were collected using chemical-target interactions database provided by Pubchem. Afterwards, network analysis between compounds and inflammation-related target genes was performed using cytoscape. Go enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed on inflammation-related targets using DAVID database. Results : 70 active compounds related to inflammation were identified, and 295 target genes related to the anti-inflammatory activity of the compound of JC were identified. In the Go biological process DB and KEGG pathway DB, "inflammatory response", "cellular response to lipopolysaccharide", "positive regulation of interleukin-6 production", and "positive regulation of protein kinase B. signaling", "positive regulation of ERK1 and ERK2 cascade", "positive regulation of I-kappaB kinase/NF-kappaB signaling", "negative regulation of apoptotic process", and "PI3K-Akt signaling pathway" were found to be mechanisms related to the anti-inflammatory effects related to the target genes of JC. The main compounds predicted to be involved in the anti-inflammatory effect of JC were quercetin, licochalcone B, (+)-catechin, kaempferol, and emodin. Conclusions : This study provides the molecular targets and potential pathways of JC on inflammation. It can be used as a basic data for using JC for various inflammatory disease in traditional korean medicine clinic.

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표/그림 (11)

그림 Fig 1. The research flow of JC acting on inflammation based on network pharmacology.
표 Table 1. Compounds in JC confirmed by pubchem for gene target analysis
표 Table 2. Genes associated with inflammation related to compounds in JC (minimum relevance scores: 5.0)
그림 Fig. 2. Dot plot for Biological processes related to targets of JC using David GO enrichment analysis
그림 Fig. 3. Dot plot for KEGG Pathways related to targets of JC using David GO enrichment analysis
표 Table 3. Biological processes related to targets of JC using David GO enrichment analysis
그림 Fig. 4. Herb-Compound Network (Ellipse: Herbs, Diamond: Compounds)
표 Table 4. KEGG Pathways related to targets of JC using David GO enrichment analysis
그림 Fig. 5. Compound-Target Network of compounds in JC for inflammation (345 nodes, 843 edges)
그림 Fig. 6. Sub-network for key compounds and targets
표 Table 5. Compound-Target Network Analysis

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