최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기한국식품영양학회지 = The Korean journal of food and nutrition, v.37 no.2, 2024년, pp.110 - 122
이정민 (호서대학교 대학원 생명공학과) , 배병준 (호서대학교 대학원 생명공학과) , 최지림 ((주)황초원) , 정영신 (호서대학교 생명공학과)
This study investigated major constituents and anti-inflammatory effects of an ethanol extract of Platycodon grandiflorum leaves. Through HPLC analysis, chlorogenic acid and luteolin-7-O-glucoside were identified as predominant constituents in the ethanol extract. Their anti-inflammatory effects wer...
Ahn KS, Noh EJ, Zhao HL, Jung SH, Kang SS, Kim YS. 2005.?Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via?suppression of nuclear factor-κB activation in RAW 264.7?cells. Life Sci 76:2315-2328
Andlauer W, Kolb J, Fu?rst P. 2000. Isoflavones from tofu are?absorbed and metabolized in the isolated rat small intestine.?J Nutr 130:3021-3027
Aziz N, Kim MY, Cho JY. 2018. Anti-inflammatory effects of?luteolin: A review of in vitro, in vivo, and in silico studies.?J Ethnopharmacol 225:342-358
Bailly C, Vergoten G. 2020. Proposed mechanisms for the?extracellular release of PD-L1 by the anticancer saponin?platycodin D. Int Immunopharmacol 85:106675
Behl T, Upadhyay T, Singh S, Chigurupati S, Alsubayiel AM,?Mani V, Vargas-De-La-Cruz C, Uivarosan D, Bustea C,?Sava C, Stoicescu M, Radu AF, Bungau SG. 2021.?Polyphenols targeting MAPK mediated oxidative stress and?inflammation in rheumatoid arthritis. Molecules 26:6570
Biesalski HK. 2007. Polyphenols and inflammation: Basic?interactions. Curr Opin Clin Nutr Metab Care 10:724-728
Boost KA, Sadik CD, Bachmann M, Zwissler B, Pfeilschifter J,?Muhl H. 2008. IFN-gamma impairs release of IL-8 by?IL-1beta-stimulated A549 lung carcinoma cells. BMC?Cancer 8:2656
Caporali S, De Stefano A, Calabrese C, Giovannelli A, Pieri M,?Savini I, Tesauro M, Bernardini S, Minieri M, Terrinoni A. 2022. Anti-inflammatory and active biological properties of?the plant-derived bioactive compounds luteolin and luteolin?7-glucoside. Nutrients 14:1155
Chahar MK, Sharma N, Dobhal MP, Joshi YC. 2011. Flavonoids:?A versatile source of anticancer drugs. Pharmacogn Rev?5:1-12
Czeczot H, Tudek B, Kusztelak J, Szymczyk T, Dobrowolska B,?Glinkowska G, Malinowski J, Strzelecka H. 1990. Isolation?and studies of the mutagenic activity in the Ames test of?flavonoids naturally occurring in medical herbs. Mutat Res?240:209-216
De Stefano A, Caporali S, Di Daniele N, Rovella V, Cardillo?C, Schinzari F, Minieri M, Pieri M, Candi E, Bernardini S,?Tesauro M, Terrinoni A. 2021. Anti-inflammatory and?proliferative properties of luteolin-7-O-glucoside. Int J Mol?Sci 22:1321
Domitrovic R, Cvijanovic O, Pugel EP, Zagorac GB,?Mahmutefendic H, Skoda M. 2013. Luteolin ameliorates?cisplatin-induced nephrotoxicity in mice through inhibition?of platinum accumulation, inflammation and apoptosis in the?kidney. Toxicology 310:115-123
Douglas CC, Johnson SA, Arjmandi BH. 2013. Soy and its?isoflavones: The truth behind the science in breast cancer.?Anticancer Agents Med Chem 13:1178-1187
Gao W, Wang C, Yu L, Sheng T, Wu Z, Wang X, Zhang D,?Lin Y, Gong Y. 2019. Chlorogenic acid attenuates dextran?sodium sulfate-induced ulcerative colitis in mice through?MAPK/ERK/JNK pathway. BioMed Res Int 2019:6769789
Ha YW, Kim YS. 2009. Preparative isolation of six major?saponins from Platycodi Radix by high-speed countercurrent chromatography. Phytochem Anal 20:207-213
Horvathova K, Chalupa I, Sebova L, Tothova D, Vachalkova, A. 2005. Protective effect of quercetin and luteolin in human?melanoma HMB-2 cells. Mutat Res 565:105-112
Hu C, Kitts DD. 2004. Luteolin and luteolin-7-O-glucoside from?dandelion flower suppress iNOS and COX-2 in RAW264.7?cells. Mol Cell Biochem 265:107-113
Huang J, Xie M, He L, Song X, Cao T. 2023. Chlorogenic acid:?A review on its mechanisms of anti-inflammation, disease?treatment, and related delivery systems. Front Pharmacol?14:1218015
Hulina-Tomaskovic A, Grdic Rajkovic M, Jelic D, Bosnar M,?Sladoljev L, Zanic Grubisic T, Rumora L. 2019. Proinflammatory effects of extracellular Hsp70 on NCI-H292?human bronchial epithelial cell line. Int J Exp Pathol 100:320-329
Inada A, Murata H, Somekawa M, Nakanishi T. 1992.?Phytochemical studies of seeds of medicinal plants II. A?new dihydroflavonol glycoside and a new 3-methyl-l-butanol glycoside from seeds of Platycodon grandiflorum A. DE CANDOLLE. Chem Pharm Bull 40:3081-3083
Jeon YS, Kim MW. 2011. The antioxidative effects and isolation?and characterization of the extracts from Morus alba L.?Korean J Food Nutr 24:94-100
Jeong CH, Choi GN, Kim JH, Kwak JH, Kim DO, Kim YJ, Heo?HJ. 2010. Antioxidant activities from the aerial parts of?Platycodon grandiflorum. Food Chem 118:278-282
Ji JD, Lee YH, Song GG. 2004. Prostaglandin E2 (PGE2): Roles?in immune responses and inflammation. J Rheum Dis 11:307-316
Ji MY, Bo A, Yang M, Xu JF, Jiang LL, Zhou BC, Li MH. 2020. The pharmacological effects and health benefits of?Platycodon grandiflorus: A medicine food homology?species. Foods 9:142
Jin M, Son KH, Chang HW. 2011. Luteolin-7-O-glucoside?suppresses leukotriene C4 production and degranulation by?inhibiting the phosphorylation of mitogen activated protein?kinases and phospholipase Cγ1 in activated mouse bone?marrow-derived mast cells. Biol Pharm Bull 34:1032-1036
Jung JI, Lee HS, Kim SM, Kim S, Lim J, Woo M, Kim EJ. 2022. Immunostimulatory activity of hydrolyzed and?fermented Platycodon grandiflorum extract occurs via the?MAPK and NF-κB signaling pathway in RAW 264.7 cells.?Nutr Res Pract 16:685-699
Kang JM, Yeo SW, Lee HY, Chang KH, Suh BD. 2000. Effect?of antioxidants and dexamethasone on inducible nitric oxide?synthase expression and nitric oxide production in murine?macrophage cells. Korean J Otorhinolaryngol-Head Neck?Surg 43:136-142
Kang KJ, Kim BH, Kim DH, Yun HJ, Cho YS, Han NE, Choi?JC, Lee SN, Choi OK. 2021. Determination of the contents?of apigenin and luteolin in vegetables. Korean J Food Nutr 34:233-241
Kim M, Hwang IG, Kim SB, Choi AJ. 2020. Chemical?characterization of balloon flower (Platycodon grandiflorum)?sprout extracts and their regulation of inflammatory activity?in lipopolysaccharide-stimulated RAW 264.7 murine?macrophage cells. Food Sci Nutr 8:246-256
Kim SH, Park SY, Park YL, Myung DS, Rew JS, Joo YE. 2017.?Chlorogenic acid suppresses lipopolysaccharide-induced?nitric oxide and interleukin-1β expression by inhibiting?JAK2/STAT3 activation in RAW264.7 cells. Mol Med Rep?16:9224-9232
Kou JJ, Shi JZ, He YY, Hao JJ, Zhang HY, Luo DM, Song JK,?Yan Y, Xie XM, Du GH, Pang XB. 2022. Luteolin?alleviates cognitive impairment in Alzheimer's disease?mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. Acta Pharmacol Sin 43:840-849
Kozlowska A, Szostak-Wegierek D. 2014. Flavonoids-food?sources and health benefits. Rocz Panstw Zakl Hig 65:79-85
Lee JW, Ji SH, Kim GS, Song KS, Um Y, Kim OT, Lee Y,?Hong CP, Shin DH, Kim CK, Lee SE, Ahn YS, Lee DY. 2015. Global profiling of various metabolites in Platycodon?grandiflorum by UPLC-QTOF/MS. Int J Mol Sci 16:26786-26796
Lee JY. 2019. Antioxidant and anti-inflammatory effects of?ethanol extracts from Platycodon grandiflorum leaves.?Master's Thesis, Hoseo Univ. Asan. Korea
Leo CH, Woodman OL. 2015. Flavonols in the prevention of?diabetes-induced vascular dysfunction. J Cardiovasc Pharmacol?65:532-544
Leyva-Lopez N, Gutierrez-Grijalva EP, Ambriz-Perez, DL,?Heredia JB. 2016. Flavonoids as cytokine modulators: A?possible therapy for inflammation-related diseases. Int J Mol?Sci 17:17060921
Li M, Wang H, Lu Y, Cai J. 2023. Luteolin suppresses?inflammation and oxidative stress in chronic obstructive?pulmonary disease through inhibition of the NOX4-mediated?NF-κB signaling pathway. Immun Inflamm Dis 11:e820
Li W, Liu Y, Wang Z, Han Y, Tian YH, Zhang GS, Sun YS,?Wang YP. 2015. Platycodin D isolated from the aerial parts?of Platycodon grandiflorum protects alcohol-induced liver?injury in mice. Food Funct 6:1418-1427
Li YC, Yeh CH, Yang ML, Kuan YH. 2012. Luteolin suppresses?inflammatory mediator expression by blocking the Akt/NFκB pathway in acute lung injury induced by lipopolysaccharide in mice. Evid Based Complement Alternat Med?2012:383608
Mazol I, Glensk M, Cisowski W. 2004. Polyphenolic compounds?from Platycodon grandiflorum A. DC. Acta Pol Pharm 61:203-208
Mortele O, Jorissen J, Spacova I, Lebeer S, van Nuijs ALN,?Hermans N. 2021. Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of?chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay. Food Funct 12:417-425
Mueller M, Hobiger S, Jungbauer A. 2010. Anti-inflammatory?activity of extracts from fruits, herbs and spices. Food Chem 122:987-996
Nabavi SF, Braidy N, Gortzi O, Sobarzo-Sanchez E, Daglia M,?Skalicka-Wozniak K, Nabavi SM. 2015. Luteolin as an anti-inflammatory and neuroprotective agent: A brief review.?Brain Res Bull 119:1-11
Palombo R, Caporali S, Falconi M, Iacovelli F, Morozzo Della?Rocca B, Lo Surdo A, Campione E, Candi E, Melino G,?Bernardini S, Terrinoni A. 2019. Luteolin-7-O-β-D-glucoside?inhibits cellular energy production interacting with HEK2 in?keratinocytes. Int J Mol Sci 20:2689
Palombo R, Savini I, Avigliano L, Madonna S, Cavani A,?Albanesi C, Mauriello A, Melino G, Terrinoni A. 2016.?Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing?proliferation, acanthosis, and inflammation in keratinocytes?and in mouse psoriatic model. Cell Death Dis 7:e2344
Panche AN, Diwan AD, Chandra SR. 2016. Flavonoids: An?overview. J Nutr Sci 5:e47
Park CM, Song YS. 2013. Luteolin and luteolin-7-O-glucoside?inhibit lipopolysaccharide-induced inflammatory responses?through modulation of NF-κB/AP-1/PI3K-Akt signaling?cascades in RAW 264.7 cells. Nutr Res Pract 7:423-429
Rafacho BPM, Stice CP, Liu C, Greenberg AS, Ausman LM,?Wang XD. 2015. Inhibition of diethylnitrosamine-initiated?alcohol-promoted hepatic inflammation and precancerous?lesions by flavonoid luteolin is associated with increased?sirtuin 1 activity in mice. Hepatobiliary Surg Nutr 4:124-134
Santana-Galvez J, Cisneros-Zevallos L, Jacobo-Velazquez DA. 2017. Chlorogenic acid: Recent advances on its dual role as a food additive and a nutraceutical against metabolic?syndrome. Molecules 22:358
Seelinger G, Merfort I, Schempp CM. 2008. Anti-oxidant,?anti-inflammatory and anti-allergic activities of luteolin.?Planta Med 74:1667-1677
Shan J, Fu J, Zhao Z, Kong X, Huang H, Luo L, Yin Z. 2009.?Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264. 7 cells through suppressing NF-κB and JNK/AP-1 activation. Int Immunopharmacol 9:1042-1048
Shen Q, Zhong YT, Liu XX, Hu JN, Qi SM. Li K, Wang Z,?Zhu HY, Li XD, Wang YP, Li W. 2023. Platycodin D?ameliorates hyperglycaemia and liver metabolic disturbance?in HFD/STZ-induced type 2 diabetic mice. Food Funct?14:74-86
Shimoi K, Okada H, Furugori M, Goda T, Takase S, Suzuki, M,?Hara Y, Yamamoto H, Kinae N. 1998. Intestinal absorption?of luteolin and luteolin 7-O-β-glucoside in rats and humans.?FEBS lett 438:220-224
Shin CY, Lee WJ, Lee EB, Choi EY, Ko KH. 2002. Platycodin?D and D3 increase airway mucin release in vivo and in vitro?in rats and hamsters. Planta Med 68:221-225
Song YS, Park CM. 2014. Luteolin and luteolin-7-O-glucoside?strengthen antioxidative potential through the modulation of?Nrf2/MAPK mediated HO-1 signaling cascade in RAW?264.7 cells. Food Chem Toxicol 65:70-75
Tanaka T, Narazaki M, Kishimoto T. 2014. IL-6 in inflammation,?immunity, and disease. Cold Spring Harb Perspect Biol?6:a016295
Trivedi HR, Puranik PK. 2023. Chlorogenic acid-optimized?nanophytovesicles: A novel approach for enhanced permeability and oral bioavailability. Future J Pharm Sci 9:116
Wang C, Zhang N, Wang Z, Qi Z, Zhu H, Zheng B, Li P, Liu?J. 2017. Nontargeted metabolomic analysis of four different?parts of Platycodon grandiflorum grown in northeast China.?Molecules 22:1280
Wang J, Mazza G. 2002. Inhibitory effects of anthocyanins and?other phenolic compounds on nitric oxide production in?LPS/IFN-γ-activated RAW 264.7 macrophages. J Agric?Food Chem 50:850-857
Wittemer SM, Ploch M, Windeck T, Muller SC, Drewelow B,?Derendorf H, Veit M. 2005. Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral?administration of artichoke leaf extracts in humans.?Phytomedicine 12:28-38
Wu J, Yang G, Zhu W, Wen W, Zhang F, Yuan J, An L. 2012.?Anti-atherosclerotic activity of platycodin D derived from?roots of Platycodon grandiflorum in human endothelial?cells. Biol Pharm Bull 35:1216-1221
Xiong J, Wang K, Yuan C, Xing R, Ni J, Hu G, Chen F, Wang?X. 2017. Luteolin protects mice from severe acute?pancreatitis by exerting HO-1-mediated anti-inflammatory?and antioxidant effects. Int J Mol Med 39:113-125
Zhang L, Wang Y, Yang D, Zhang C, Zhang N, Li M, Liu Y. 2015. Platycodon grandiflorus: An ethnopharmacological,?phytochemical and pharmacological review. J Ethnopharmacol?164:147-161
Zubik L, Meydani M. 2003. Bioavailability of soybean?isoflavones from aglycone and glucoside forms in American?women. Am J Clin Nutr 77:1459-1465
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
※ AI-Helper는 부적절한 답변을 할 수 있습니다.