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[해외논문] A Point Mutation in HLA-A*0201 Results in Failure to Bind the TAP Complex and to Present Virus-Derived Peptides to CTL 원문보기

Immunity, v.4 no.5, 1996년, pp.505 - 514  

Peace-Brewer, Amy L (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Tussey, Lynda G (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Matsui, Masanori (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Li, Guoxuan (Linberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Quinn, Daniel G (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Frelinger, Jeffrey A (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractMutating the HLA-A*0201 heavy chain from threonine to lysine at position 134 (T134K) results in a molecule that presents exogenous peptide, but cannot present endogenously derived antigen. This is reflected in diminished cell surface expression and altered intracellular trafficking of T134K....

참고문헌 (42)

  1. Immunity Androlewicz 1 7 1994 10.1016/1074-7613(94)90004-3 Human transporters associated with antigen processing possess a promiscuous peptide-binding site 

  2. Proc. Natl. Acad. Sci. USA Androlewicz 90 9130 1993 10.1073/pnas.90.19.9130 Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner 

  3. J. Exp. Med. Baas 176 147 1992 10.1084/jem.176.1.147 Peptide-induced stabilization and intracellular localization of empty HLA class I complexes 

  4. Cell Barnstable 14 9 1978 10.1016/0092-8674(78)90296-9 Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis 

  5. Curr. Opin. Immunol. Bijlmakers 5 21 1993 10.1016/0952-7915(93)90076-5 Putting together an MHC class I molecule 

  6. Nature Bjorkman 329 506 1987 10.1038/329506a0 Structure of the human class I histocompatibility antigen, HLA-A2 

  7. J. Immunol. Carreno 155 4726 1995 10.4049/jimmunol.155.10.4726 TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man 

  8. Nature Cerundolo 345 449 1990 10.1038/345449a0 Presentation of viral antigen controlled by a gene in the major histocompatibility complex 

  9. Proc. Natl. Acad. Sci. USA DeMars 82 8183 1985 10.1073/pnas.82.23.8183 Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens 

  10. Nature Deverson 348 738 1990 10.1038/348738a0 MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters 

  11. Nature Falk 351 290 1991 10.1038/351290a0 Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules 

  12. Cell Germain 76 287 1994 10.1016/0092-8674(94)90336-0 MHC-dependent antigen processing and peptide presentation 

  13. Science Grandea 270 105 1995 10.1126/science.270.5233.105 Dependence of peptide binding by MHC class I molecules on their interaction with TAP 

  14. Nature Guagliardi 343 133 1990 10.1038/343133a0 Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment 

  15. Science Henderson 255 1264 1992 10.1126/science.1546329 HLA-A2.1-associated peptides from a mutant cell line 

  16. Immunogenetics Hill 37 95 1993 10.1007/BF00216831 Different rates of HLA class I molecule assembly which are determined by amino acid sequence in the alpha 2 domain 

  17. Science Hosken 248 367 1990 10.1126/science.2326647 Defective presentation of endogenous antigen by a cell line expressing class I molecules 

  18. Nature Kelly 355 641 1992 10.1038/355641a0 Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex 

  19. Nature Laemmli 227 680 1970 10.1038/227680a0 Cleavage of structural proteins during assembly of bacteriophage T4 

  20. Immunity Lee 3 591 1995 10.1016/1074-7613(95)90130-2 The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP association 

  21. Nature Ljunggren 346 476 1990 10.1038/346476a0 Empty MHC class I molecules come out in the cold 

  22. Proc. Natl. Acad. Sci. USA McMichael 85 9194 1988 10.1073/pnas.85.23.9194 Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes 

  23. Science Monaco 250 1723 1990 10.1126/science.2270487 Transport protein genes in the murine MHC 

  24. Immunogenetics Moots 34 141 1991 10.1007/BF00205816 A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells 

  25. Immunogenetics Neefjes 23 164 1986 10.1007/BF00373817 An analysis of class I antigens of man and other species by one-dimensional IEF and immunoblotting 

  26. J. Exp. Med. Neefjes 178 1971 1993 10.1084/jem.178.6.1971 Folding and assembly of major histocompatibility complex class I heterodimers in the endoplasmic reticulum of intact cells precedes the binding of peptide 

  27. Nature Ortmann 368 864 1994 10.1038/368864a0 MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding 

  28. Human Immunol. Parham 3 277 1981 10.1016/0198-8859(81)90065-3 Partial purification and some properties of BB7.2 

  29. Proc. Natl. Acad. Sci. USA Pogue 92 8166 1995 10.1073/pnas.92.18.8166 Amino-terminal alteration of the HLA-A*0201-restricted human immunodeficiency virus pol peptide increases complex stability and in vitro immunogenicity 

  30. EMBO J. Salter 5 943 1986 10.1002/j.1460-2075.1986.tb04307.x Impaired assembly and transport of HLA-A and -B antigens in a mutant T×B cell hybrid 

  31. Cell Schumacher 62 563 1990 10.1016/0092-8674(90)90020-F Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro 

  32. Cell Shepherd 74 577 1993 10.1016/0092-8674(93)80058-M TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective 

  33. Nature Spies 348 744 1990 10.1038/348744a0 A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway 

  34. Nature Spies 355 644 1992 10.1038/355644a0 Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer 

  35. J. Immunol. Storkus 138 1657 1987 10.4049/jimmunol.138.6.1657 NK susceptibility varies inversely with target cell class I HLA antigen expression 

  36. Science Suh 264 1322 1994 10.1126/science.8191286 Interaction of MHC class I molecules with the transporter associated with antigen processing 

  37. Nature Townsend 340 443 1989 10.1038/340443a0 Association of class I major histocompatibility heavy and light chains induced by viral peptides 

  38. Cell Townsend 42 457 1985 10.1016/0092-8674(85)90103-5 Cytotoxic T cells recognize fragments of the influenza nucleoprotein 

  39. Nature Trowsdale 348 741 1990 10.1038/348741a0 Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters 

  40. Immunity Tussey 3 65 1995 10.1016/1074-7613(95)90159-0 Different MHC class I alleles compete for presentation of overlapping viral epitopes 

  41. Nature Wei 356 443 1992 10.1038/356443a0 HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides 

  42. J. Immunol. Zweerink 150 1763 1993 10.4049/jimmunol.150.5.1763 Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells 

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