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[해외논문] A Point Mutation in HLA-A*0201 Results in Failure to Bind the TAP Complex and to Present Virus-Derived Peptides to CTL 원문보기

Immunity, v.4 no.5, 1996년, pp.505 - 514  

Peace-Brewer, Amy L (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Tussey, Lynda G (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Matsui, Masanori (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Li, Guoxuan (Linberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Quinn, Daniel G (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA) ,  Frelinger, Jeffrey A (Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractMutating the HLA-A*0201 heavy chain from threonine to lysine at position 134 (T134K) results in a molecule that presents exogenous peptide, but cannot present endogenously derived antigen. This is reflected in diminished cell surface expression and altered intracellular trafficking of T134K....

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