[논문]Effect of terlipressin on in vitro vascular hyporeactivity of portal hypertensive rats

Heinemann, A.; Stauber, R.E.

doi:10.1016/S0168-8278(96)80271-6

[해외논문] Effect of terlipressin on in vitro vascular hyporeactivity of portal hypertensive rats

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.24 no.6, 1996년, pp.739 - 746

Heinemann, A. (bDepartment of Medicine, Karl Franzens University, ,, Graz, Austria) , Stauber, R.E.

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Backgrounds/Aims: Isolated vessels of portal hypertensive rats exhibit decreased responsiveness to vasoconstrictors. The vasopressin analogue terlipressin analogue terlipressin is used in the treatment of portal hypertension since it is known to reduce portal pressure, an effect that is thought to arise from splanchnic vasoconstriction via stimulation of vasoconstrictor V1 receptors. This study assessed the effect of terlipressin on the in vitro vascular reactivity of portal hypertensive rats to the α-adrenoceptor agonist methoxamine.Methods: Portal hypertension was produced by portal vein ligation. Sham-operated rats served as controls. In isolated perfused mesentric arteries of portal vien ligated and sham-operated rats pressor responses to methoxamine (3 nmol-3 μmol) were determined in the absence and presence of the nitric oxide synthase inhibitor Ng-nitro-L-arginine methyl ester (L-NAME; 100 μM), terlipressin or the selective V2 receptor agonist desmopressin (each 0.5 μM). In addition, the direct pressor properties of terlipressin (3 pmol-100 nmol) were compared to arginine vasopressin (3 pmol-1 nmol) in vessels of normal rats.Results: Mesenteric vessels of portal vein ligated rats were markedly hyporeactive to methoxamine, even in the presence of L-NAME. Terlipressin alone reduced and in combination with L-NAME abolished the difference in reactivity to methoxamine between the portal vein ligated and sham-operated groups, while desmopressin was ineffective. Arginine vasopressin potently contracted vessels of normal rats with a threshold dose of 10 pmol and was maximally effective at 300 pmol. In contrast, terlipressin failed to produce pressor responses up to 100 nmol.Conclusions: Hyporeactivity of mesenteric vessels of portal vein ligated rats to methoxamine is predominantly independent of nitric oxide. Terlipressin alone ameliorates and in combination with L-NAME abolishes the hyporesponsiveness to methoxamine presumably by inhibiting the nitric oxide-independent mechanism that underlies the reduced responsiveness to methoxamine in portal hypertension. This effect of terlipressin appears to be independent of stimulation of V2 as well as vasoconstrictor V1 receptors.

참고문헌 (36)

Clin Sci Mol Med Finberg 61 535 1981 Blunted pressor response to angiotensin and sympathomimetic amines in bile duct-ligated dogs
Am J Physiol Kiel 248 G192 1985 Reduced vascular sensitivity to norepinephrine in portal hypertensive rats
Hepatology Castro 18 367 1993 Impaired responsiveness to angiotensin II in experimental cirrhosis: role of nitric oxide
Gastroenterology Hartleb 107 1085 1994 10.1016/0016-5085(94)90233-X Vascular hyporesponsiveness to endothelin-1 in rats with cirrhosis

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Gastroenterology Ryan 105 1167 1993 10.1016/0016-5085(93)90963-D Impaired reactivity of the peripheral vasculature to pressor agents in alcoholic cirrhosis

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Am J Physiol Bomzon 252 G158 1987 Vascular reactivity in experimental portal hypertension
Am J Physiol Sieber 262 G996 1992 In vitro hyporeactivity to methoxamine in portal hypertensive rats: reversal by nitric oxide blockade
Lancet Vallance 337 776 1991 10.1016/0140-6736(91)91384-7 Hyperdynamic circulation in cirrhosis: a role for nitric oxide?

상세보기
Hepatology Bomzon 20 1343 1994 10.1002/hep.1840200535 The nitric oxide hypothesis and the hyperdynamic circulation in cirrhosis

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Am J Physiol Iwata 263 G149 1992 Role of EDRF in splanchnic blood flow of normal and chronic portal hypertensive rats
Am J Physiol Garcia-Pagan 30 G984 1994 Effects of continued NO inhibition on portal hypertensive syndrome after portal vein stenosis in rats
Hepatology Weigert 20 98A 1994 Endothelium-dependent vascular hyporesponsiveness without nitric oxide synthase induction in aorta of cirrhotic rats
Eur J Pharmacol Heinemann 278 87 1995 10.1016/0014-2999(95)00138-B The role of inducible nitric oxide synthase in vascular hyporeactivity of endotoxin-treated and portal hypertensive rats

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Am J Physiol Vorobioff 244 G52 1983 Hyperdynamic circulation in portal hypertensive model: a primary factor for maintenance of chronic portal hypertension
Eur J Clin Invest Blanchet 12 327 1982 10.1111/j.1365-2362.1982.tb02240.x Changes in splanchnic blood flow in portal hypertensive rats

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Hepatology Gimson 6 410 1986 10.1002/hep.1840060314 A randomized trial of vasopressin and vasopressin plus nitroglycerin in the treatment of acute variceal hemorrhage

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Hepatology Walker 6 112 1986 10.1002/hep.1840060121 Terlipressin in bleeding esophageal varices: a placebo-controlled doubleblind study

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Gut Westaby 29 372 1988 10.1136/gut.29.3.372 Haemodynamic response to intravenous vasopressin and nitroglycerin in portal hypertension

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Dig Dis Sci Merkel 33 1103 1988 10.1007/BF01535785 Hemodynamic changes of systemic hepatic and splenic circulation following triglycyl-lysin-vasopressin administration in alcoholic cirrhosis

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J Hepatol Lin 10 370 1990 10.1016/0168-8278(90)90149-L Systemic and portal haemodynamic changes following triglycyllysine vasopressin plus nitroglycerin administration in patients with hepatitis B-related cirrhosis

상세보기
J Hepatol Lebrec 17 102 1993 10.1016/S0168-8278(05)80529-X Effects of terlipressin on hemodynamics and oxygen content in conscious portal vein-stenosed and cirrhotic rats receiving propanolol

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Endocrinology Karmazyn 102 1230 1978 10.1210/endo-102-4-1230 Changes of vascular reactivity induced by low vasopressin concentration: interactions with cortisol and lithium and possible involvement of prostaglandin

상세보기
Br J Pharmacol Randall 95 646 1988 10.1111/j.1476-5381.1988.tb11687.x Endothelium-dependent modulation of the pressor activity of arginine vasopressin in the isolated superior mesenteric arterial bed of the rat

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J Physiol McGregor 177 12 1965 10.1113/jphysiol.1965.sp007572 The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat

상세보기
J Cardiovasc Pharmacol Adeagbo 21 423 1993 10.1097/00005344-199303000-00011 Varying extracellular [K+]: a functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed

상세보기
J Endocrinol Forsling 85 237 1980 10.1677/joe.0.0850237 Conversion of triglycylvasopressin to lysine-vasopressin in man

상세보기
Hepatology Moreau 12 7 1990 10.1002/hep.1840120103 Abnormal pressor response to vasopressin in patients with cirrhosis: evidence for impaired buffering mechanisms

상세보기
Gastroenterology Moreau 106 1016 1994 10.1016/0016-5085(94)90762-5 Altered control of vascular tone by adenosine triphosphate-sensitive potassium channels in rats with cirrhosis

상세보기
Am J Physiol Wakatsuki 263 H491 1992 Vasopressin modulates K+-channel activities of cultured smooth muscle rcells from porcine coronary artery
Pharmacology Huang 50 86 1995 10.1159/000139270 Change in vascular cAMP and cGMP contents in portal hypertensive rats

상세보기
Gastroenterology Wu 106 A280 1994 Protein kinase-A inhibition restores intestinal microvascular responses to norepinephrine in portal hypertensive rats
Regul Pept Thibonnier 38 1 1992 10.1016/0167-0115(92)90067-5 Signal transduction of V2-vascular vasopressin receptors

상세보기
Am J Physiol Murray 263 H1643 1992 Effect of protein kinase C inhibitors on endothelin-and vasopressin-induced constriction of the rat basilary artery
Acta Endocrinol Copenh Eikvar 128 568 1993 10.1530/acta.0.1280568 Protein kinase C activation and positive and negative agonist regulation of 3′,5′-cyclic adenosine monophosphate levels in cultured rat Sertoli cells

상세보기
Biochem Biophys Res Commun Minami 190 262 1993 10.1006/bbrc.1993.1040 Protein kinase C inhibits the Ca2+-activated K+ channel of cultured porcine coronary artery smooth muscle cells

상세보기
Am J Physol Kohan 265 F670 1993 Endothelin B receptor mediates ET-1 effects on cAMP and PGE2 accumulation in rat IMCD

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DOI : 10.1016/S0168-8278(96)80271-6
European Association for the Study of the Liver : 저널
Elsevier : 저널

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[해외논문] Effect of terlipressin on in vitro vascular hyporeactivity of portal hypertensive rats

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