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[해외논문] Bioavailability of cyclosporine in rats after intragastric administration: a comparative study of the L2-phase and two other lipid-based vehicles

Transplant immunology, v.4 no.4, 1996년, pp.313 - 317  

Bojrup, Malin (Address of correspondence: Malin Bojrup, Camurus AB, Ideon, Gamma 1, Sö) ,  Qi, Zhongquan (lvegatan 41, S-223 70 Lund, Sweden) ,  Björkman, Sven (Department of Experimental Research, Karolinska Institute, Huddinge Hospital, Huddinge Sweden) ,  Östraat, Öyvind (Hospital Pharmacy and Karolinska Institute, Huddinge Hospital, Huddinge Sweden) ,  Landin, Britta (Department of Surgery, Malmö) ,  Ljusberg-Wahren, Helena (University Hospital, Malmö) ,  Ekberg, Henrik (, Karolinska Institute, Huddinge Hospital, Huddinge Sweden)

Abstract AI-Helper 아이콘AI-Helper

AbstractThe purpose of this study was to evaluate formulations based on surface active dietary lipids only as oral vehicles for cyclosporine. The absolute bioavailability of cyclosporine from two new lipid vehicles was determined in rats after intragastric administration and compared to that of Sand...

참고문헌 (30)

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  3. Clin Pharmacokinet Fahr 24 472 1993 10.2165/00003088-199324060-00004 Cyclosporin clinical pharmacokinetics 

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  7. Lancet Sokol 338 212 1991 10.1016/0140-6736(91)90349-T Improvement of cyclosporine absorption in children after liver transplantation by means of water-soluble vitamin E 

  8. Methods Find Exp Clin Pharmacol Ritschel 13 205 1991 Microemulsions for improved peptide absorption from the gastrointestinal tract 

  9. Methods Find Exp Clin Pharmacol Ritschel 12 127 1990 Improvement of peroral absorption of cyclosporine A by microemulsions 

  10. Transplantation Elzinga 47 394 1989 10.1097/00007890-198902000-00043 The effect of dimethyl sulfoxide on the absorption of cyclosporine in rats 

  11. Pharmaceutical Mueller 11 151 1994 Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation 

  12. Pharmaceutical Mueller 11 301 1994 Improved dose linearity of cyclosporine pharmacokinetics from a microemulsion formulation 

  13. J Pharm Sci Kovarik 83 444 1994 10.1002/jps.2600830336 Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation 

  14. Lancet Trull 341 433 1993 10.1016/0140-6736(93)93025-V Cyclosporin absorption from microemulsion formulation in liver transplant recipient 

  15. Larsson 1994 

  16. A controlled-release composition for a biologically active material dissolved or dispersed in an L2-phase. Engstrom 1992 

  17. Biopharm Drugs Dispos Ueda 4 113 1983 10.1002/bdd.2510040203 Intestinal lymphatic absorption of cyclosporine A following oral administration in an olive oil solution in rats 

  18. Drug Metab Dispos Sangalli 16 749 1988 Cyclosporine pharmacokinetics in rats and interspecies comparison in dogs, rabbits, rats and humans 

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  20. J Pharm Pharmacol Hedayati 44 122 1992 10.1111/j.2042-7158.1992.tb03575.x Absorption kinetics of cyclosporine in the rat 

  21. Drug Metab Dispos Quijano 21 141 1993 Effect of atropine on gastrointestinal motility and the bioavailability of cyclosporine A in rats 

  22. Biopharm Drug Dispos Lindberg-Freijs 15 75 1994 10.1002/bdd.2510150107 Dose dependent absorption and linear disposition of cyclosporine A in rat 

  23. Drug Metab Dispos Luke 18 158 1990 Bioavailability assessment of cyclosporine in the rat 

  24. Pharmaceutical Reymond 5 677 1988 In vivo model for ciclosporin intestinal absorption in lipid vesicles 

  25. Int J Pharmaceutics Myers 78 217 1992 10.1016/0378-5173(92)90374-B Systemic bioavailability of penclomedine (NSC-338720) fro oil-in-water emulsions administered intraduodenally to rats 

  26. Pharmaceutical Tarr 6 40 1989 Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size 

  27. J Dispers Sci Technol Pilman 3 335 1982 10.1080/01932698208943645 Interfacial tension between an inverse micellar phase of lipid components and aqueous protein solutions 

  28. Lipids Lindstrom 16 749 1981 10.1007/BF02535343 Aqueous lipid phases of relevance to intestinal fat digestion and absorption 

  29. Biochemistry Staggers 29 2028 1990 10.1021/bi00460a011 Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1 Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings 

  30. Biochemistry Hernell 29 2041 1990 10.1021/bi00460a012 Physical-Chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings 

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