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Cell, v.87 no.5, 1996년, pp.917 - 927
Moran, John V (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA) , Holmes, Susan E (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA) , Naas, Thierry P (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA) , DeBerardinis, Ralph J (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA) , Boeke, Jef D (Department of Molecular Biology and Genetics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA) , Kazazian Jr., Haig H (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)
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AbstractWe previously isolated two human L1 elements (L1.2 and LRE2) as the progenitors of disease-producing insertions. Here, we show these elements can actively retrotranspose in cultured mammalian cells. When stably expressed from an episome in HeLa cells, both elements retrotransposed into a var...
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