$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

[해외논문] High Frequency Retrotransposition in Cultured Mammalian Cells 원문보기

Cell, v.87 no.5, 1996년, pp.917 - 927  

Moran, John V (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA) ,  Holmes, Susan E (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA) ,  Naas, Thierry P (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA) ,  DeBerardinis, Ralph J (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA) ,  Boeke, Jef D (Department of Molecular Biology and Genetics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA) ,  Kazazian Jr., Haig H (Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractWe previously isolated two human L1 elements (L1.2 and LRE2) as the progenitors of disease-producing insertions. Here, we show these elements can actively retrotranspose in cultured mammalian cells. When stably expressed from an episome in HeLa cells, both elements retrotransposed into a var...

참고문헌 (63)

  1. J. Mol. Biol. Altschul 215 403 1990 10.1016/S0022-2836(05)80360-2 Basic local alignment search tool 

  2. Nucl. Acids Res. Arkhipova 23 4480 1995 10.1093/nar/23.21.4480 Complex patterns of transcription of a Drosophila retrotransposon in vivo and in vitro by RNA polymerases II and III 

  3. Science Belfort 262 1009 1993 10.1126/science.7694364 An expanding universe of introns 

  4. Curr. Opin. Cell Biol. Boeke 3 502 1991 10.1016/0955-0674(91)90079-E Retrotransposition mechanisms 

  5. Cell Boeke 40 491 1985 10.1016/0092-8674(85)90197-7 Ty elements transpose through an RNA intermediate 

  6. Cell Bureau 77 479 1994 10.1016/0092-8674(94)90210-0 Transduction of a cellular gene by a plant retroelement 

  7. Mol. Cell. Biol. Burke 7 2221 1987 The site-specific ribosomal insertion element type II of Bombyx mori (R2Bm) contains the coding sequence for a reverse transcriptase-like enzyme 

  8. J. Mol. Biol. Burton 187 291 1986 10.1016/0022-2836(86)90235-4 Conservation throughout mammalia and extensive protein-encoding capacity of the highly repeated DNA long interspersed sequence one 

  9. Proc. Natl. Acad. Sci. USA Conway 82 3949 1985 10.1073/pnas.82.12.3949 A sequence downstream of AAUAAA is required for formation of simian virus 40 late mRNA 3′ termini in frog oocytes 

  10. Science Cooley 239 1121 1988 10.1126/science.2830671 Insertional mutagenesis of the Drosophila genome with single P elements 

  11. Proc. Natl. Acad. Sci. USA Curcio 88 936 1991 10.1073/pnas.88.3.936 Single-step selection for Ty1 element retrotransposition 

  12. Mol. Biol. Evol. Demers 3 179 1986 Long interspersed L1 repeats in rabbit DNA are homologous to L1 repeats of rodents and primates in an open-reading-frame region 

  13. Cell Derr 67 355 1991 10.1016/0092-8674(91)90187-4 RNA-mediated recombination in S. cerevisiae 

  14. Science Dombroski 254 1805 1991 10.1126/science.1662412 Isolation of an active human transposable element 

  15. Mol. Cell. Biol. Dombroski 14 4485 1994 Anin vivo assay for the reverse transcriptase of human retrotransposon L1 in Saccharomyces cerevisiae 

  16. Proc. Natl. Acad. Sci. USA Evans 88 8792 1991 10.1073/pnas.88.19.8792 Retrotransposition of a mouse L1 element 

  17. Nucl. Acids Res. Fanning 15 2251 1987 10.1093/nar/15.5.2251 The LINE-1 DNA sequences in four mammalian orders predict proteins that conserve homologies to retrovirus proteins 

  18. Biochim. Biophys. Acta Fanning 910 203 1987 10.1016/0167-4781(87)90112-6 LINE-1 

  19. Cell Feng 87 1996 10.1016/S0092-8674(00)81997-2 Human L1 retrotransposon encodes a conserved endonuclease required for retrotransposition 

  20. Biotechniques Freeman 17 47 1994 A modified indicator gene for selection of retrotransposition events in mammalian cells 

  21. Nature Hattori 321 625 1986 10.1038/321625a0 L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein 

  22. Cell Heidmann 64 159 1991 10.1016/0092-8674(91)90217-M Retrotransposition of a mouse IAP sequence tagged with an indicator gene 

  23. Proc. Natl. Acad. Sci. USA Heidmann 85 2219 1988 10.1073/pnas.85.7.2219 An indicator gene to demonstrate intracellular transposition of defective retroviruses 

  24. EMBO J. Hohjoh 15 630 1996 10.1002/j.1460-2075.1996.tb00395.x Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA 

  25. Holmes, S.E. (1994). Characterization of active human L1 elements, Ph.D. Thesis, Johns Hopkins Univ., Baltimore, MD. 

  26. J. Biol. Chem. Holmes 267 19765 1992 10.1016/S0021-9258(19)88618-0 Studies on p40, the leucine zipper motif-containing protein encoded by the first open reading frame of an active human LINE-1 transposable element 

  27. Nature Genet. Holmes 7 143 1994 10.1038/ng0694-143 A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion 

  28. Hutchison, C.A., III, Hardies, S.C., Loeb, D.D., Shehee, W.R., and Edgell, M.H. (1989). LINES and related retroposons: long interspersed repeated sequences in the eucaryotic genome. In Mobile DNA, D.E. Berg and M.M. Howe eds. (Washington, DC: ASM Press), pp. 593-617. 

  29. EMBO J. Jensen 10 1927 1991 10.1002/j.1460-2075.1991.tb07719.x An indicator gene for detection of germline retrotransposition in transgenic Drosophila demonstrates RNA-mediated transposition of the LINE I element 

  30. Biochem. Biophys. Res. Commun. Jensen 202 111 1994 10.1006/bbrc.1994.1900 Retrotransposition of the Drosophila LINE I element can induce deletion in target DNA 

  31. Proc. Natl. Acad. Sci. USA Katzir 82 1054 1985 10.1073/pnas.82.4.1054 “Retroposon” insertion into the cellular oncogene c-myc in canine transmissible venereal tumor 

  32. Nature Kazazian 332 164 1988 10.1038/332164a0 Haemophilia A resulting from de novo insertion of L1 sequences represents a novel mechanism for mutation in man 

  33. Nature Genet. Kingsmore 7 136 1994 10.1038/ng0694-136 Glycine receptor β-subunit gene mutation in spastic mouse associated with LINE-1 element insertion 

  34. J. Biol. Chem. Kohrman 271 17576 1996 10.1074/jbc.271.29.17576 Mutation detection in the med and medJ alleles of the sodium chanel Scn8a 

  35. Methods Enzymol. Kunkel 204 125 1991 10.1016/0076-6879(91)04008-C Efficient site-directed mutagenesis using uracil-containing DNA 

  36. Nucl. Acids Res. Kurose 23 3704 1995 10.1093/nar/23.18.3704 RNA polymerase III dependence of the human L1 promoter and possible participation of the RNA polymerase II factor YY1 in the RNA polymerase III transcription system 

  37. Proc. Natl. Acad. Sci. USA Leibold 87 6990 1990 10.1073/pnas.87.18.6990 Translation of LINE-1 DNA elements in vitro and in human cells 

  38. Mol. Cell. Biol. Luan 15 3882 1995 10.1128/MCB.15.7.3882 RNA template requirements for target DNA-primed reverse transcription by the R2 retrotransposable element 

  39. Cell Luan 72 595 1993 10.1016/0092-8674(93)90078-5 Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site 

  40. EMBO J. Maestre 14 6333 1995 10.1002/j.1460-2075.1995.tb00324.x mRNA retroposition in human cells 

  41. Mol. Cell. Biol. Martin 11 4804 1991 Ribonucleoprotein particles with LINE-1 RNA in mouse embryonal carcinoma cells 

  42. Science Mathias 254 1808 1991 10.1126/science.1722352 Reverse transcriptase encoded by a human retrotransposon 

  43. Cancer Res. Miki 52 643 1992 Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer 

  44. Nucl. Acids Res. Minakami 12 3139 1992 10.1093/nar/20.12.3139 Identification of an internal cis-element essential for the human L1 transcription and a nuclear factor(s) binding to the element 

  45. Mol. Cell. Biol. Moran 15 2828 1995 10.1128/MCB.15.5.2828 Mobile group II introns of yeast mitochondrial DNA are novel site-specific retroelements 

  46. Nature Morse 333 87 1988 10.1038/333087a0 Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma 

  47. Neuron Mulhardt 13 1003 1994 10.1016/0896-6273(94)90265-8 The spastic mouse 

  48. J. Clin. Invest. Narita 91 1862 1993 10.1172/JCI116402 Insertion of a 5′ truncated L1 element into the 3′ end of exon 44 of the dystrophin gene resulted in skipping of the exon during splicing in a case of Duchenne muscular dystrophy 

  49. Proc. Natl. Acad. Sci. USA Pelisson 88 4907 1991 10.1073/pnas.88.11.4907 Evidence for retrotransposition of the I factor, a LINE element of Drosophila melanogaster 

  50. Sambrook 1989 Molecular Cloning 

  51. Genomics Scott 1 113 1987 10.1016/0888-7543(87)90003-6 Origin of the human L1 elements 

  52. Gene Singer 135 183 1993 10.1016/0378-1119(93)90064-A LINE-1 

  53. Science Swain 255 841 1992 10.1126/science.1371365 Mechanism of transduction by retroviruses 

  54. Mol. Cell. Biol. Swergold 10 6718 1990 Identification, characterization, and cell specificity of a human LINE-1 promoter 

  55. FEBS Lett. Tanaka 376 146 1995 10.1016/0014-5793(95)01262-2 Unusual long target duplication by insertion of intracisternal A-particle element in radiation-induced acute myeloid leukemia cells in mouse 

  56. Hum. Mol. Genet. Takahara 5 989 1996 10.1093/hmg/5.7.989 Dysfunction of the Orleans reeler gene arising from exon skipping due to transposition of a full-length copy of an active L1 sequence into the skipped exon 

  57. EMBO J. Tchenio 12 1487 1993 10.1002/j.1460-2075.1993.tb05792.x Generation of processed pseudogenes in murine cells 

  58. J. Biol. Chem. Usdin 264 15681 1989 10.1016/S0021-9258(19)84886-X The structure of the guanine-rich polypurine:polypyrimidine sequence at the right end of the rat L1 (LINE) element 

  59. Genomics Woods-Samuels 4 290 1989 10.1016/0888-7543(89)90332-7 Characterization of a nondeleterious L1 insertion in an intron of the human factor VIII gene and further evidence of open reading frames in functional L1 elements 

  60. EMBO J. Xiong 9 3353 1990 10.1002/j.1460-2075.1990.tb07536.x Origin and evolution of retroelements based upon their reverse transcriptase sequences 

  61. Nature Yates 313 812 1985 10.1038/313812a0 Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells 

  62. Cell Zimmerly 82 545 1995 10.1016/0092-8674(95)90027-6 Group II intron mobility occurs by target DNA-primed reverse transcription 

  63. Cell Zimmerly 83 529 1995 10.1016/0092-8674(95)90092-6 A group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility 

관련 콘텐츠

오픈액세스(OA) 유형

GOLD(Hybrid)

저자가 APC(Article Processing Charge)를 지불한 논문에 한하여 자유로운 이용이 가능한, hybrid 저널에 출판된 논문

저작권 관리 안내
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로