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[해외논문] Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation 원문보기

Immunity, v.5 no.5, 1996년, pp.461 - 477  

Lucas, Bruno (Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-1892, USA) ,  Germain, Ronald N (Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-1892, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractCD4+CD8+TCRlo thymocytes are the precursors of CD4+ and CD8+ mature T cells, whose receptors show specific recognition of peptide–MHC class II and MHC class I complexes, respectively. How T cells emerge from the intrathymic differentiation process with selective expression of either C...

참고문헌 (67)

  1. Eur. J. Immunol Baron 24 1933 1994 10.1002/eji.1830240834 A human CD4 transgene rescues CD4−CD8+ cells in β2-microglobulin-deficient mice 

  2. Cell Berg 58 1035 1989 10.1016/0092-8674(89)90502-3 Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand 

  3. EMBO J Borgulya 10 913 1991 10.1002/j.1460-2075.1991.tb08024.x Development of the CD4 and CD8 lineage of T cells 

  4. Cell Chan 73 225 1993 10.1016/0092-8674(93)90225-F Another view of the selective model of thymocyte selection 

  5. Immunol. Rev Chan 135 119 1993 10.1111/j.1600-065X.1993.tb00646.x A challenge to the instructive model of positive selection 

  6. EMBO J Chan 13 4482 1994 10.1002/j.1460-2075.1994.tb06770.x Role of coreceptors in positive selection and lineage commitment 

  7. Cell Cosgrove 66 1051 1991 10.1016/0092-8674(91)90448-8 Mice lacking MHC class II molecules 

  8. Proc. Natl. Acad. Sci. USA Crump 90 10739 1993 10.1073/pnas.90.22.10739 Thymocyte development in major histocompatibility complex-deficient mice 

  9. Curr. Opin. Immunol Davis 6 266 1994 10.1016/0952-7915(94)90100-7 Thymocyte lineage commitment 

  10. Int. Immunol Davis 7 1977 1995 10.1093/intimm/7.12.1977 Disrupted development of thymocytes expressing a transgenic TCR upon CD4 overexpression 

  11. Cell Davis 73 237 1993 10.1016/0092-8674(93)90226-G Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes 

  12. Nature Davis 334 395 1988 10.1038/334395a0 The T cell receptor genes and T cell recognition 

  13. Nature Doyle 330 256 1987 10.1038/330256a0 Interaction between CD4 and class II MHC molecules mediates cell adhesion 

  14. J. Exp. Med Fowlkes 162 802 1985 10.1084/jem.162.3.802 Early T lymphocytes 

  15. J. Exp. Med Guidos 172 835 1990 10.1084/jem.172.3.835 T cell receptor-mediated negative selection of autoreactive T lymphocytes precursors occurs after commitment to the CD4 or CD8 lineages 

  16. Cell Hogquist 76 17 1994 10.1016/0092-8674(94)90169-4 T cell receptor antagonist peptides induce positive selection 

  17. Proc. Natl. Acad. Sci. USA Itano 91 220 1994 10.1073/pnas.91.1.220 Stochastic component to development of class I major histocompatibility complex-specific T cells 

  18. J. Exp. Med Itano 183 731 1996 10.1084/jem.183.3.731 The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells 

  19. Nature Jameson 369 750 1994 10.1038/369750a0 Specificity and flexibility in thymic selection 

  20. J. Exp. Med Kearse 181 193 1995 10.1084/jem.181.1.193 Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+CD8+ thymocytes 

  21. J. Immunol Kersh 154 1057 1995 10.4049/jimmunol.154.3.1057 Role of TCR specificity in CD4 versus CD8 lineage commitment 

  22. J. Exp. Med Kishimoto 181 649 1995 10.1084/jem.181.2.649 Upregulation of surface markers on dying thymocytes 

  23. Science Koller 248 1227 1990 10.1126/science.2112266 Normal development of mice deficient in β2m, MHC class I proteins, and CD8+ T cells 

  24. J. Immunol Kydd 155 3806 1995 10.4049/jimmunol.155.8.3806 Intermediate steps in thymic positive selection 

  25. J. Immunol Lucas 151 4574 1993 10.4049/jimmunol.151.9.4574 Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes 

  26. J. Immunol Lucas 153 53 1994 10.4049/jimmunol.153.1.53 Production, selection, and maturation of thymocytes with high surface density of TcR 

  27. J. Exp. Med Lucas 181 1623 1995 10.1084/jem.181.5.1623 Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway 

  28. J. Immunol Lucas 156 1743 1996 10.4049/jimmunol.156.5.1743 CD4lo TCRint thymocytes do not belong to the CD8 lineage maturation pathway 

  29. J. Exp. Med Lundberg 179 1475 1994 10.1084/jem.179.5.1475 Small cortical thymocytes are subject to positive selection 

  30. J. Exp. Med Lundberg 181 1643 1995 10.1084/jem.181.5.1643 Intermediate steps in positive selection 

  31. Science Madrenas 267 515 1995 10.1126/science.7824949 ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists 

  32. J Immunol Mannie 154 2642 1995 10.4049/jimmunol.154.6.2642 Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4 

  33. Eur. J. Immunol Marodon 24 196 1994 10.1002/eji.1830240131 Generation of mature T cells in the thymus 

  34. Immunity Matechak 4 337 1996 10.1016/S1074-7613(00)80247-2 MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent 

  35. Proc. Natl. Acad. Sci. USA Nakayama 90 10534 1993 10.1073/pnas.90.22.10534 Decreased signaling competence as a result of receptor overexpression 

  36. Nature Norment 336 79 1988 10.1038/336079a0 Cell-cell adhesion mediated by CD8 and MHC class I molecules 

  37. Int. Immunol Ohaka 8 297 1996 10.1093/intimm/8.3.297 In vitro differentiation and commitment of CD4+8+ thymocytes to the CD4 lineage without TCR engagement 

  38. J. Immunol Olszowy 155 4236 1995 10.4049/jimmunol.155.9.4236 Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells, and lymphoid cell lines 

  39. Proc. Natl. Acad. Sci. USA Page 91 4057 1994 10.1073/pnas.91.9.4057 Negative selection of CD4+CD8+ thymocytes by T-cell receptor peptide antagonists 

  40. J. Immunol Pénit 137 2115 1986 In vivo thymocyte maturation 

  41. J. Immunol Pénit 142 3369 1989 10.4049/jimmunol.142.10.3369 Cell proliferation and differentiation in the fetal and early postnatal mouse thymus 

  42. J. Immunol Pénit 154 5103 1995 10.4049/jimmunol.154.10.5103 Cell expansion and growth arrest phases during the transition from precursor (CD4−8−) to immature (CD4+8+) thymocytes in normal and genetically modified mice 

  43. J. Immunol Petrie 151 1273 1993 10.4049/jimmunol.151.3.1273 CD4+CD8− and CD4−CD8+ mature thymocytes require different post-selection processing for final development 

  44. J. Exp. Med Ravichandran 179 727 1994 10.1084/jem.179.2.727 Evidence for differential intracellular signaling via CD4 and CD8 molecules 

  45. Annu. Rev. Immunol Robey 12 675 1994 10.1146/annurev.iy.12.040194.003331 Selective events in T cell development 

  46. Cell Robey 64 99 1991 10.1016/0092-8674(91)90212-H Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage 

  47. J. Exp. Med Robey 179 1997 1994 10.1084/jem.179.6.1997 Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice 

  48. Immunol. Today Scollay 16 268 1995 10.1016/0167-5699(95)80179-0 Thymic emigration 

  49. Cell Sloan-Lancaster 79 913 1994 10.1016/0092-8674(94)90080-9 Partial T cell signaling 

  50. J Immunol Spain 152 1709 1994 10.4049/jimmunol.152.4.1709 A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes 

  51. Immunity Suzuki 2 413 1995 10.1016/1074-7613(95)90149-3 Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages 

  52. Nature Swat 351 150 1991 10.1038/351150a0 Clonal deletion of immature CD4+CD8+ thymocytes in suspension culture by extrathymic antigen-presenting cells 

  53. Nature Teh 335 229 1988 10.1038/335229a0 Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells 

  54. Science van Meerwijk 261 911 1993 10.1126/science.8102208 Development of mature CD8+ thymocytes 

  55. Semin. Immunol van Meerwijk 6 231 1994 10.1006/smim.1994.1030 The different roles of MHC class recognition in thymocyte CD4 versus CD8 lineage commitment and positive selection 

  56. J. Immunol van Meerwijk 154 6314 1995 10.4049/jimmunol.154.12.6314 Evidence for lineage commitment and initiation of positive selection by thymocytes with intermediate surface phenotypes 

  57. J. Exp. Med Vasquez 175 1307 1992 10.1084/jem.175.5.1307 In vivo and in vitro clonal deletion of double-positive thymocytes 

  58. Cell Veillette 55 301 1988 10.1016/0092-8674(88)90053-0 The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck 

  59. J. Immunol Veis 151 2546 1993 10.4049/jimmunol.151.5.2546 Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes 

  60. Immunol. Today von Boehmer 7 333 1986 10.1016/0167-5699(86)90139-8 The selection of the αβ heterodimeric T cell receptor for antigen 

  61. Immunol. Rev von Boehmer 101 21 1988 10.1111/j.1600-065X.1988.tb00731.x The T-cell receptor for antigen in T-cell development and repertoire selection 

  62. Immunol. Today von Boehmer 10 57 1989 10.1016/0167-5699(89)90307-1 The thymus selects the useful, neglects the useless and destroys the harmful 

  63. Immunity Wiest 4 495 1996 10.1016/S1074-7613(00)80415-X TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck 

  64. Eur. J. Immunol Williams 26 532 1996 10.1002/eji.1830260305 Inhibition of thymocyte negative selection by T cell receptor antagonist peptides 

  65. Nature Zijlstra 344 742 1990 10.1038/344742a0 β2-microglobulin deficient mice lack CD4−CD8+ cytolytic T cells 

  66. Nature Zúñiga-Pflücker 338 76 1989 10.1038/338076a0 Positive selection of CD4−CD8+ cells in the thymus of normal mice 

  67. J. Exp. Med Zúñiga-Pflücker 171 427 1990 10.1084/jem.171.2.427 CD8 is required during positive selection of CD4−CD8+ T cells 

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