[논문]Familial clustering of HBV pre-C and pre-S mutants

Santantonio, T.; Jung, M.-C.; Pastore, G.; Angarano, G.; Gunther, S.; Will, H.

doi:10.1016/S0168-8278(97)80034-7

[해외논문] Familial clustering of HBV pre-C and pre-S mutants

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.26 no.2, 1997년, pp.221 - 227

Santantonio, T. (aHeinrich-Pette-Institute fur Experimentelle Virologie und Immunologie an der Universitat Hamburg, ,, Hamburg, Germany) , Jung, M.-C. , Pastore, G. , Angarano, G. , Gunther, S. , Will, H.

Abstract ▼ AI-Helper

Background/Aims: Little is known about the persistence and risk of infection with hepatitis B viruses (HBV) containing mutations in the pre-C and pre-S region. The aim of this study was to study the long-term persistence and the risk of intrafamilial spreading of these variants.Methods: Serological markers were analyzed immunologically and pre-C and pre-S sequences of HBV DNA in sera from several members of five families by DNA amplification and direct sequencing.Results: In most HBV-DNA positive individuals of each family, either the dominant HBV population or a subpopulation had a stop codon in the pre-C region which prevented expression of e-antigen. The pre-S region of the dominant virus populations of 815 HBV-DNA positive sera showed different deletions or a pre-S2 translation initiation codon mutation in addition to various point mutations. Selection for pre-C and pre-S mutant viruses from a predominant ''wildtype'' virus population was observed in three individuals during the natural course of infection. Persistence of a pre-C/pre-S double mutant virus as a stable strain for 6 years was found in one patient.Conclusions: These data indicate extensive intrafamilial clustering of HBV variants with mutations in the pre-C and pre-S regions due to patient-specific selection mechanisms and long-term persistence of some mutants as stable strains. The type of viruses found suggests that occasionally virus subpopulations are selectively transmitted or become a dominant virus population after selection.

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DOI : 10.1016/S0168-8278(97)80034-7
European Association for the Study of the Liver : 저널
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