[논문]Anti-cell surface endothelial antibodies in sera from cardiac and kidney transplant recipients: association with chronic rejection

doi:10.1016/S0966-3274(97)80021-4

[해외논문] Anti-cell surface endothelial antibodies in sera from cardiac and kidney transplant recipients: association with chronic rejection

Transplant immunology, v.5 no.1, 1997년, pp.17 - 24

Ferry, Berle L (Department of Immunology, Tissue Typing, Churchill Hospital, Oxford UK) , Welsh, Ken I (Department of Immunology, Tissue Typing, Churchill Hospital, Oxford UK) , Dunn, Michael J (National Heart and Lung Institute (Imperial College) at Harefield Hospital, Harefield UK) , Law, David (Department of Immunology, Tissue Typing, Churchill Hospital, Oxford UK) , Proctor, Jeanette (Department of Immunology, Tissue Typing, Churchill Hospital, Oxford UK) , Chapel, Helen (Department of Immunology, Tissue Typing, Churchill Hospital, Oxford UK) , Yacoub, Magdi H (National Heart and Lung Institute (Imperial College) at Harefield Hospital, Harefield UK) , Rose, Marlene L (National Heart and Lung Institute (Imperial College) at Harefield Hospital, Harefield UK)

Abstract ▼ AI-Helper

AbstractThe aetiologies of accelerated or transplant-associated coronary artery disease (TxCAD) following cardiac transplantation and chronic rejection following renal transplantation remain ill-defined. Previous studies have used Western blotting to demonstrate an association between the formation of anti-endothelial (anti-EC) antibodies and TxCAD after heart transplantation. However, Western blotting favours detection of cytosolic proteins. The objectives of this study were to determine whether flow cytometry, a method which detects antigens on the cell surface, could be used to detect anti-EC antibodies and also whether the observations would extend to renal transplant patients with chronic rejection. Flow cytometry was used to look for antibodies reactive with the surface antigens of macrovascular and microvascular endothelial cell lines in sera from 44 cardiac and 35 renal transplant recipients before and after transplantation. In addition, sera from normals (n = 20), patients with nontransplant CAD (n = 50) and patients with unrelated diseases (n = 40) were investigated. Of 23 cardiac recipients who had developed TxCAD at one or two years post-transplant, 61% had IgM and 13% had IgG anti-EC antibodies post-transplantation. In contrast, in 21 cardiac recipients who had not developed TxCAD 14% had IgM and 14% IgG anti-EC antibodies. There was little evidence for the presence of anti-EC antibodies in cardiac recipients before transplantation. Of 26 renal transplant recipients whose transplants failed due to chronic rejection, 42% and IgG and 19% IgM anti-EC antibodies post-transplantation. of nine renal recipients whose grafts were either functioning normally or who had acutely rejected, none had IgG or IgM anti-EC antibodies either pre- or post-transplantation. The anti-EC antibodies were not found in normals and were rare (less than 4%) in the other disease groups; they do not appear to be autoantibodies. In conclusion, these results suggest that FACS assay could be an informative and rapid test to provide more information on chronic rejection following cardiac and renal transplantation.

참고문헌 (37)

Curr Opin Immunol Azuma 6 770 1994 10.1016/0952-7915(94)90083-3 Chronig graft rejection

상세보기
Transplant Proc Hayry 26 3159 1994 Chronic allograft rejection, an update

상세보기
Banner 17 1987 Cardiac transplantation at Harefield Hospital
Circulation Uretsky 76 827 1987 10.1161/01.CIR.76.4.827 Development of coronary artery disease in cardiac transplant patients receiving patients receiving immunosuppressive therapy with cyclosporine and prednisolone

상세보기
JAMA Gratton 261 3561 1989 10.1001/jama.261.24.3561 Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis

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Lancet Barbir 340 1500 1992 10.1016/0140-6736(92)92756-6 Liproprotein (a) and accelerated coronary artery disease in cardiac allograft recipients

상세보기
Transplant Proc Bieber 13 207 1981 Complications in long term survivors of cardiac transplantation

상세보기
J Heart Lung Transplant Hosenpud 11 9 1992 Cardiac allograftvasculopathy: current concepts, recent developments and future directions.

상세보기
Transplant Rev Rose 7 140 1993 10.1016/S0955-470X(05)80013-8 Antibody mediated rejection following cardiac transplantation

상세보기
Circulation Petrossian 80 122 1989 Relationship between survival and development of country artery disease and anti-HLA antibodies after cardiac transplantation
J Heart Lung Transplant Rose 11 S120 1992 Relation of HLA antibodies and graft atherosclerosis in human cardiac transplant recipients
Circulation Hess 68 94 1983 Accelerated atherosclerosis in cardiac tranplantation
Lancet Dunn 339 1566 1992 10.1016/0140-6736(92)91832-S Antiendothelial antibodies and coronary artery disease after cardiac transplantation

상세보기
J Heart Lung Transplant Crisp 13 81 1994 Antiendothelial antibodies after heart transplantation: the acclerating factor in transplant-associated coronary artery disease?
Circulation Hosenpud 92 205 1995 10.1161/01.CIR.92.2.205 Cardiac allograft vasculopathy, Association with cell mediated but not humoral alloimmunity to donor specific vascular endothelium

상세보기
Transplant Proc Hardy 11 389 1979 The development of specificity of anti-B cell antibodies during humoral rejection of kidney allografts
Transplantation Mohanakumar 32 61 1981 10.1097/00007890-198107000-00013 Serological characterisation of antibodies eluted from chronically rejected human renal allografts

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Surgery Brasile 99 637 1986 The association of antivascular endothelial cell antibody with hyperacute rejection: a case report
Transpl Int Harmer 3 66 1990 10.1111/j.1432-2277.1990.tb01894.x Novel antibodies associated with unexplained loss of renal allografts

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Transplant Proc Paul 12 43 1980 Antibodies against renal endothelial alloantigens

상세보기
Transpl Int Al Hussein 8 214 1995 10.1111/j.1432-2277.1995.tb01506.x The clinical significance of post-transplantation non-HLA antibodies in renal transplantation

상세보기
Proc Natl Acad Sci USA Edgell 80 3734 1983 10.1073/pnas.80.12.3734 Permanent cell line expressing human factor VIII-related antigen established by hybridisation

상세보기
J Invest Dermatol Ades 99 683 1992 10.1111/1523-1747.ep12613748 Establishment of an immortalised human microvascular endothelial cell line.

상세보기
J Heart Lung Transplant Wheeler 14 S188 1995 Characterisation of endothelial antigens associated with transplant associated coronary artery disease
Transplantation Martin 44 50 1987 10.1097/00007890-198707000-00012 Post-transplant antidonor lymphocytotoxic antibody production in relation to graft outcome.

상세보기
Transplantation Halloran 53 550 1992 10.1097/00007890-199203000-00011 The significance of the anti class I response II. Clinical and pathological featutres of renal transplants with anti class I antibody

상세보기
Transplantation Suciu-Foca 51 716 1991 10.1097/00007890-199103000-00033 The role of anti-HLA antibodies in heart transplantation

상세보기
Transplantation Smith 53 1358 1992 10.1097/00007890-199206000-00034 Specificity of lymphocytotxic antibodies formed after cardiac transplantation and correlation with rejection episodes

상세보기
Transplantation Brasile 40 672 1985 10.1097/00007890-198512000-00020 Identification of the antibody to vascular endothelial cells in patients undergoing cardiac transplantation

상세보기
J Thorac Cardivoasc Surg Trento 95 37 1988 10.1016/S0022-5223(19)35384-X Role of the antibody to vascular endothelial cells in hyperacute rejection in patients undergoing cardiac transplantation

상세보기
Transplant proc Tixier 25 931 1993 Characterisation of antiendothelial cell and antiheart antibodies following heart transplantation
Transplantation Yard 55 1287 1993 10.1097/00007890-199306000-00015 The clinical significance of allospecific antibodies against endothelial cells detected with an antibody dependent cellular cytoxicity assay for vascular rejection and graft loss after renal transplantation

상세보기
Nature Bjorkman 329 506 1987 10.1038/329506a0 Structure of the human class I histocompatibility antigen, HLA-A2

상세보기
Khamashta 111 1994 Antibodies to endothelial cells and vascular dysfunction in progressive systemic sclerosis and mixed connective tissue disease
Am. J Pathol Page 141 673 1992 Antigenic heterogeneity of vascular endothelium

상세보기
Transplant Immunol Abdul-Karim 3 192 1995 10.1016/0966-3274(95)80025-5 Anti-epithelial (anti-549)_antibodies: their nature, specificity and relevance to transplantation

상세보기
Transplantation Pidwell 60 56 1995 10.1097/00007890-199509270-00008 In vitro stimulation of human endothelial cells by sera from a subpopulation of high percentage panel reactive antibody patients

상세보기

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DOI : 10.1016/S0966-3274(97)80021-4
OCLC ECO : 저널
Elsevier : 저널 > 논문

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