Mele, A.
(aLaboratorio di Epidemiologia e Biostatistica, I.S.S., Universita di Torino,, , Italy)
,
Stroffolini, T.
,
Palumbo, F.
,
Gallo, G.
,
Ragni, P.
,
Balocchini, E.
,
Tosti, M.E.
,
Corona, R.
,
Marzolini, A.
,
Moiraghi, A.
,
SEIEVA Collaborating Group
Background/Aims: This study aimed to evaluate the incidence of and risk factors for acute viral hepatitis A (HAV) in Italy.Methods: Data were from a surveillance system for type-specific acute viral hepatitis (SEIEVA). To estimate the association of hepatitis A cases with the potential risk factors ...
Background/Aims: This study aimed to evaluate the incidence of and risk factors for acute viral hepatitis A (HAV) in Italy.Methods: Data were from a surveillance system for type-specific acute viral hepatitis (SEIEVA). To estimate the association of hepatitis A cases with the potential risk factors (Odds Ratios) and the proportion of all hepatitis A cases attributable to a given risk factor (population attributable risk), hepatitis B cases were used as controls. Independent predictors of HAV were estimated by conditional multiple logistic regression.Results: During the period 1985-1994, 25 553 viral hepatitis cases were reported. Of these, 6408 (25%) were due to hepatitis A (HAV). HAV incidence declined from 10/100 000 in 1985 to 2/100 000 in 1987. Since 1991, however, an increase in HAV has been observed. The majority of cases were 15-24 years old; the incidence was higher in males and in subjects residing in southern Italy. Only one death (0.02%) was observed. Shellfish consumption was the most frequently reported risk factor (62%). The proportion of cases reporting personal contact with an icteric case, travel to a high-medium endemic areas, and family contact with a child attending a day-care centre (household of day-care child) was 17%, 19% and 15%, respectively. The results of multivariate analysis showed that shellfish consumption (OR=2.6; 95% CI=2.4-2.9), travel to endemic areas for people residing in northern and central Italy (OR=5.4; 95% CI=4.6-6.2) and household of day-care child (OR=1.2; 95% CI=1.03-1.4), were all types of exposure independently associated with HAV. The estimates of population-attributable risk show that shellfish consumption explained as many as 42.2%, travel to high-medium endemic areas for people residing in northern and central Italy 24.2%, and household of day-care child only 1.4% of all acute hepatitis A cases in Italy.Conclusions: These findings indicate that HAV in Italy is mainly a food-borne disease. Vaccination against hepatitis A is strongly recommended for travellers to endemic areas.
Background/Aims: This study aimed to evaluate the incidence of and risk factors for acute viral hepatitis A (HAV) in Italy.Methods: Data were from a surveillance system for type-specific acute viral hepatitis (SEIEVA). To estimate the association of hepatitis A cases with the potential risk factors (Odds Ratios) and the proportion of all hepatitis A cases attributable to a given risk factor (population attributable risk), hepatitis B cases were used as controls. Independent predictors of HAV were estimated by conditional multiple logistic regression.Results: During the period 1985-1994, 25 553 viral hepatitis cases were reported. Of these, 6408 (25%) were due to hepatitis A (HAV). HAV incidence declined from 10/100 000 in 1985 to 2/100 000 in 1987. Since 1991, however, an increase in HAV has been observed. The majority of cases were 15-24 years old; the incidence was higher in males and in subjects residing in southern Italy. Only one death (0.02%) was observed. Shellfish consumption was the most frequently reported risk factor (62%). The proportion of cases reporting personal contact with an icteric case, travel to a high-medium endemic areas, and family contact with a child attending a day-care centre (household of day-care child) was 17%, 19% and 15%, respectively. The results of multivariate analysis showed that shellfish consumption (OR=2.6; 95% CI=2.4-2.9), travel to endemic areas for people residing in northern and central Italy (OR=5.4; 95% CI=4.6-6.2) and household of day-care child (OR=1.2; 95% CI=1.03-1.4), were all types of exposure independently associated with HAV. The estimates of population-attributable risk show that shellfish consumption explained as many as 42.2%, travel to high-medium endemic areas for people residing in northern and central Italy 24.2%, and household of day-care child only 1.4% of all acute hepatitis A cases in Italy.Conclusions: These findings indicate that HAV in Italy is mainly a food-borne disease. Vaccination against hepatitis A is strongly recommended for travellers to endemic areas.
참고문헌 (18)
J Hepatol Shapiro 18 S11 1993 10.1016/S0168-8278(05)80371-X Worldwide epidemiology of hepatitis A virus infection
Am J Epidemiol Lednar 122 226 1985 10.1093/oxfordjournals.aje.a114093 Frequency of illness associated with epidemic hepatitis A virus infection in adults
Am J Epidemiol Mele 130 540 1989 10.1093/oxfordjournals.aje.a115368 Recurrent epidemic hepatitis A associated with consumption of raw shellfish, probably controlled through public health measures
Ital J Gastroenterol Sagliocca 27 181 1995 Case control study of risk factors for hepatitis A: Naples 1990-1991
Eur J Epidemiol Mele 2 300 1986 10.1007/BF00419494 Integrated epidemiological system for acute viral hepatitis in Italy (SEIEVA): description and preliminary results
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