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[해외논문] The RNA–DNA Hybrid Maintains the Register of Transcription by Preventing Backtracking of RNA Polymerase 원문보기

Cell, v.89 no.1, 1997년, pp.33 - 41  

Nudler, Evgeny (Public Health Research Institute, New York, New York 10016, USA) ,  Mustaev, Arkady (Public Health Research Institute, New York, New York 10016, USA) ,  Goldfarb, Alex (Public Health Research Institute, New York, New York 10016, USA) ,  Lukhtanov, Evgeny (Epoch Pharmaceuticals, Inc., Bothell, Washington 98021, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractAn 8–9 bp RNA–DNA hybrid in the transcription elongation complex is essential for keeping the RNA 3′ terminus engaged with the active site of E. coli RNA polymerase (RNAP). Destabilization of the hybrid leads to detachment of the transcript terminus, RNAP backtracking, a...

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