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Cell, v.89 no.3, 1997년, pp.365 - 371
Kadosh, David (Department of Biological Chemistry, Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA) , Struhl, Kevin (Department of Biological Chemistry, Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA)
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AbstractSin3 and Rpd3 negatively regulate a diverse set of yeast genes. A mouse Sin3-related protein is a transcriptional corepressor, and a human Rpd3 homolog is a histone deacetylase. Here, we show that Sin3 and Rpd3 are specifically required for transcriptional repression by Ume6, a DNA-binding p...
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