[논문]Prevalence of liver cell dysplasia and association with HCC in a series of 100 cirrhotic liver explants

Le Bail, B.; Bernard, P.-H.; Carles, J.; Balabaud, C.; Bioulac-Sage, P.

doi:10.1016/S0168-8278(97)80321-2

[해외논문] Prevalence of liver cell dysplasia and association with HCC in a series of 100 cirrhotic liver explants

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.27 no.5, 1997년, pp.835 - 842

Le Bail, B. (aLaboratoire de Pathologie - Groupe de Recherche pour l'Etude du Foie, Universite Bordeaux 2, ,, Bordeaux, France) , Bernard, P.-H. , Carles, J. , Balabaud, C. , Bioulac-Sage, P.

Abstract ▼ AI-Helper

Background/Aims: Liver cell dysplasia of large (LLCD) and small (SLCD) cell types may represent a premalignant change. We sought to evaluate their prevalence, relationship with the gross type of cirrhosis, aetiology of liver disease, and the presence of hepatocellular carcinoma in a series of cirrhotic livers.Methods: The presence and pattern of SLCD and LLCD were evaluated by careful histological analysis in 100 consecutive cirrhotic livers of viral (49%) or non viral (51%) aetiology, and with or without hepatocellular carcinoma. Prevalences were compared using Chi-square or Fisher's tests; relative risk for hepatocellular carcinoma was evaluated by the odds ratio.Results: Dysplasia was found in 82100 of livers. Eighty-one had LLCD, with (n=49) or without (n=32) associated SLCD. SLCD alone was found in only one case. LLCD and SLCD tended to be more frequent and extensive in mixed or macronodula cirrhosis than in micronodular cirrhosis. LLCD was significantly more frequent and extensive in cirrhosis due to hepatitis B, as was SLCD in cirrhosis due to hepatitis B virus or biliary diseases, where it showed a different pattern (focal vs diffuse, respectively). LLCD and SLCD were both significantly associated with the presence of hepatocellular carcinoma, even of small size. Small foci of SLCD and widespread LLCD were the two conditions which showed the strongest association with hepatocellular carcinoma, with odds ratios of: 6.33 and 3.88, respectively. Widespread SLCD was not relevant for hepatocellular carcinoma in biliary diseases.Conclusions: Liver cell dysplasia may be considered an additional risk factor for hepatocellular carcinoma in patients with cirrhosis and should be looked for in biopsies. Widespread LLCD and SLCD with a focal pattern are particularly relevant for hepatocellular carcinoma, whereas widespread small cell changes found in biliary diseases seem to have a different biological significance.

참고문헌 (40)

Hepatology Okuda 15 948 1992 10.1002/hep.1840150532 Hepatocellular carcinoma: recent progress

상세보기
J Viral Hepatitis Moradpour 1 265 1994 10.1111/j.1365-2893.1994.tb00058.x The molecular mechanisms of hepatocellular carcinoma

상세보기
J Gastroenterol Hepatol Okuda 1 79 1986 10.1111/j.1440-1746.1986.tb01760.x What is the precancerous lesion for hepatocellular carcinoma in man?

상세보기
Liver Nakanuma 13 1 1993 10.1111/j.1600-0676.1993.tb00597.x Adenomatous hyperplasia of the liver as a precancerous lesion

상세보기
Semin Liver Dis Theise 15 360 1995 10.1055/s-2007-1007287 Macroregenerative (dysplastic) nodules and hepato-carcinogenesis

상세보기
Hum Pathol Le Bail 26 897 1995 10.1016/0046-8177(95)90014-4 Adenomatous hyperplasia in cirrhotic livers: histological evaluation, cellular density and proliferative activity of 35 macronodular lesions in the cirrhotic explants of 10 adult French patients

상세보기
J Clin Pathol Anthony 26 217 1973 10.1136/jcp.26.3.217 Liver cell dysplasia: a premalignant condition

상세보기
Ishak 1994 10.1007/978-3-642-85156-8 Histological Typing of Tumours of the Liver
Cancer Watanabe 51 2197 1983 10.1002/1097-0142(19830615)51:12<2197::AID-CNCR2820511208>3.0.CO;2-5 Morphologic studies of the liver cell dysplasia

상세보기
Hum Pathol Bartok 12 794 1981 10.1016/S0046-8177(81)80082-2 Clinicopathological studies of liver cirrhosis and hepatocellular carcinoma in a general hospital

상세보기
Cancer Akagi 54 315 1984 10.1002/1097-0142(19840715)54:2<315::AID-CNCR2820540223>3.0.CO;2-6 Liver cell dysplasia and hepatitis B surface antigen in liver cirrhosis and hepatocellular carcinoma

상세보기
Histopathology Roncalli 9 209 1985 10.1111/j.1365-2559.1985.tb02436.x Liver cell dysplasia and hepatocellular carcinoma: a histological and immunohistochemical study

상세보기
Cancer Roncalli 57 1515 1986 10.1002/1097-0142(19860415)57:8<1515::AID-CNCR2820570813>3.0.CO;2-J Liver cell dysplasia in cirrhosis: a serologic and immunohistochemical study

상세보기
Hum Pathol Roncalli 19 471 1988 10.1016/S0046-8177(88)80499-4 A morphometric study of liver cell dysplasia

상세보기
Cancer Cohen 57 1535 1956 10.1002/1097-0142(19860415)57:8<1535::AID-CNCR2820570816>3.0.CO;2-8 Liver cell dysplasia in normal, cirrhotic, and hepatocellular carcinoma patients

상세보기
Anal Quant Cytol Histol Matturi 10 339 1988 Morphometric characteristics of hepatocellular dysplasia

상세보기
Hepatogastroenterology Giannini 34 95 1987 Morphological precursors of hepatocellular carcinoma: a morphometric analysis
Int J Cancer Roncalli 44 204 1989 10.1002/ijc.2910440203 Abnormal DNA content in liver-cell dysplasia: a flow cytometric study

상세보기
Mod Pathol Rubin 7 677 1994 Comparative image cytometric DNA ploidy of liver cell dysplasia and hepatocellular carcinoma
Hum Pathol Thomas 23 496 1992 10.1016/0046-8177(92)90126-N Liver cell dysplasia: a DNA aneuploid lesion with distinct morphological features

상세보기
Histol Histopathol Zhao 9 73 1994 Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguishable by karyometry and PCNA labelling, and their features resemble distinct grades of hepatocellular carcinoma

상세보기
Appl Pathol Police 6 73 1988 Hepatocellular dysplasia: immunohistochemical and morphometrical evaluation

상세보기
Virchows Arch Zhao 424 613 1994 10.1007/BF01069741 Immunohistochemical analysis of p53 protein overexpression in liver cell dysplasia and in hepatocellular carcinoma
Histopathology Zhao 25 237 1994 10.1111/j.1365-2559.1994.tb01323.x Immunohistochemical detection of bcl2 protein in liver lesions: bcl2 protein is expressed in hepatocellular carcinoma but not in liver cell dysplasia

상세보기
Cancer Henmi 55 2594 1995 10.1002/1097-0142(19850601)55:11<2594::AID-CNCR2820551111>3.0.CO;2-7 Karyometric analysis of liver cell dysplasia and hepatocellular carcinoma: evidence against precancerous nature of liver cell dysplasia

상세보기
Semin Diag Pathol Crawford 7 115 1990 Pathologic assessment of liver cell dysplasia and benign liver tumors: differentiation from malignant tumors
Ital J Gastroenterol Podda 24 39 1992 Liver-cell dysplasia and hepatocellular carcinoma

상세보기
Ann Pathol Le Bail 15 332 1995 Approche actuelle de la carcinogenese hepatique. De la cirrhose au carcinome hepatocellulaire

상세보기
Cancer Adachi 72 2902 1993 10.1002/1097-0142(19931115)72:10<2902::AID-CNCR2820721008>3.0.CO;2-2 Proliferating cell nuclear antigen in hepatocellular carcinoma and small liver cell dysplasia

상세보기
Am J Surg Pathol Ferrell 17 1113 1993 10.1097/00000478-199311000-00004 Proposal for standardized criteria for the diagnosis of benign, borderline and malignant lesions arising in cirrhotic advanced liver disease

상세보기
Hepatology 22 983 1995 10.1002/hep.1840220341
Arch Pathol Lab Med Lefkowitch 111 170 1987 Liver cell dysplasia and hepatocellular carcinoma in non-A, non-B hepatitis

상세보기
Acta Path Jap Sakurai 28 705 1978 Liver cell dysplasia and hepatitis B surface and core antigens in cirrhosis and hepatocellular carcinoma of autopsy cases
Int J Cancer Ho 28 571 1981 10.1002/ijc.2910280507 Liver cell dysplasia in association with hepatocellular carcinoma, cirrhosis and hepatitis B surface antigen in Hong Kong

상세보기
Hepatology Hytiroglou 21 703 1995 Macroregenerative nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature
Hepatology Ganne-Carrie 23 1112 1996 10.1002/hep.510230527 Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in western patients with cirrhosis

상세보기
Gastroenterology Borzio 108 812 1995 10.1016/0016-5085(95)90455-7 Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study

상세보기
Hepatology Ferrell 16 1372 1992 10.1002/hep.1840160612 Incidence and diagnostic features of macroregenerative nodules vs small hepatocellular carcinoma in cirrhotic livers

상세보기
Virchows Arch A Pathol Anat Nakanuma 422 17 1993 10.1007/BF01605128 Unusual hepatocellular lesions in primary biliary cirrhosis resembling but unrelated to hepatocellular neoplasms

상세보기
J Pathol Le Bail 181 330 1997 10.1002/(SICI)1096-9896(199703)181:3<330::AID-PATH765>3.0.CO;2-7 Extracellular matrix and integrin expression in early hepatocarcinogenesis in human cirrhotic livers

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DOI : 10.1016/S0168-8278(97)80321-2
European Association for the Study of the Liver : 저널
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