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Cell, v.91 no.4, 1997년, pp.479 - 489
Li, Peng (Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, at Dallas, Dallas, Texas 75235, USA) , Nijhawan, Deepak (Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, at Dallas, Dallas, Texas 75235, USA) , Budihardjo, Imawati (Howard Hughes Medical Institute, Department of Biochemistry, University of Texas Southwestern Medical Center, at Dallas, Dallas, Texas 75235, USA) , Srinivasula, Srinivasa M (Center for Apoptosis Research, Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA) , Ahmad, Manzoor (Center for Apoptosis Research, Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA) , Alnemri, Emad S (Center for Apoptosis Research, Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA) , Wang, Xiaodong (Howard Hughes Medical Institute, Department of Bioch)
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AbstractWe report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3 was identified as a member of the caspase family, caspase-9. Caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in t...
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