[논문]Hepatitis C virus (HCV) genotypes in Spanish patients with HCV infection: relationship between HCV genotype 1b, cirrhosis and hepatocellular carcinoma

Lopez-Labrador, F.X.; Ampurdanes, S.; Forns, X.; Castells, A.; Saiz, J.C.; Costa, J.; Bruix, J.; Sanchez Tapias, J.M.; Jimenez de Anta, M.T.; Rodes, J.

doi:10.1016/S0168-8278(97)80137-7

[해외논문] Hepatitis C virus (HCV) genotypes in Spanish patients with HCV infection: relationship between HCV genotype 1b, cirrhosis and hepatocellular carcinoma

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.27 no.6, 1997년, pp.959 - 965

Lopez-Labrador, F.X. (aLiver Unit, Hospital Clinic, Universitat de Barcelona, ,, Catalonia, Spain) , Ampurdanes, S. , Forns, X. , Castells, A. , Saiz, J.C. , Costa, J. , Bruix, J. , Sanchez Tapias, J.M. , Jimenez de Anta, M.T. , Rodes, J.

Abstract ▼ AI-Helper

Background/Aims: The influence of the infecting virus genotype on the progression of the underlying liver disease in patients with chronic hepatitis C virus (HCV) infection remains controversial. The aim of this study was to investigate the prevalence of HCV genotypes in Spanish patients with chronic HCV infection and to elucidate the relationship between the infecting genotype and severity of the disease.Methods: A cross-sectional, retrospective analysis of frequency distribution of HCV genotypes was carried out in 414 Spanish patients with chronic HCV infection, including 243 patients with asymptomatic or minimally symptomatic chronic hepatitis, 112 patients with cirrhosis and hepatocellular carcinoma and 59 patients with decompensated cirrhosis. HCV genotype was determined by restriction fragment length polymorphisms of the 5' non-coding region.Results: Infection with HCV genotype 1b was found in 72% of patients with chronic hepatitis and in more than 90% of patients with cirrhosis, with or without hepatocellular carcinoma. Older age, infection with genotype 1b and absence of overt parenteral exposure as a possible source of infection were associated with cirrhosis and hepatocellular carcinoma by univariate analysis and this association was confirmed by regression analysis.Conclusions: HCV genotype 1b is associated with advanced liver disease in our geographical area. However, this may be related to a cohort-effect caused by over-representation of genotype 1b in older patients with more advanced disease, because, in our country, this HCV genotype appeared earlier in time and is therefore associated with more prolonged periods of infection.

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DOI : 10.1016/S0168-8278(97)80137-7
European Association for the Study of the Liver : 저널
Elsevier : 저널

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표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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