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Cell, v.91 no.6, 1997년, pp.753 - 763
Ordway, Jared M (Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA) , Tallaksen-Greene, Sara (Department of Neurology, University of Michigan, Ann Arbor, Michigan 48104, USA) , Gutekunst, Claire-Anne (Department of Neurology, Emory University, Atlanta, Georgia 30329, USA) , Bernstein, Eve M (Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA) , Cearley, Jamie A (Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA) , Wiener, Howard W (Department of Oral Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA) , Dure IV, Leon S (Department of Pediatric Neurology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA) , Lindsey IV, Russell (Department of Comparative Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA) , Hersch IV, Steven M (Department of Neurology, Emory University, Atlanta, Georgia 30329, USA) , Jope IV, Richard S (Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmin) , Albin IV, Roger.L , Detloff IV, Peter J
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AbstractThe mutations responsible for several human neurodegenerative disorders are expansions of translated CAG repeats beyond a normal size range. To address the role of repeat context, we have introduced a 146-unit CAG repeat into the mouse hypoxanthine phosphoribosyltransferase gene (Hprt). Muta...
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