[논문]Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertion

Dallenbach, A.; Renner, E.L.

doi:10.1016/0168-8278(95)80288-6

[해외논문] Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertion

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.22 no.3, 1995년, pp.338 - 348

Dallenbach, A. , Renner, E.L.

Abstract ▼ AI-Helper

Based on studies in the pig, secretin choleresis has been proposed to be initiated by colchicine-inhibitable, exocytic insertion into the basolateral cholangiocyte membrane of intracytoplasmatic vesicles containing a H+ ATPase. Formal prof of this hypothesis in the intact liver of other species, however, is lacking. The effect of the microtubule inhibitor colchicine on the ductular bile formation and HCO-3 secretion induced by secretin was, therefore, explored in a secretin-responsive rat model characterized by marked hyperplasia of bile ductules. While colchicine pretreatment significantly decreased basal bile flow from 142.1+/-8.8 to 83.4+/-8.2 μl. min-1.kg-1 (p<0.001) and basal biliary erythritol clearance from 112.7+/-6.3 to 69.9+/-7.0 μl.min-1. kg-1 (ps0.05), it did not significantly affect basal biliary [HCO-3], nor basal biliary bile acid output. Moreover, colchicine did not alter the effects of secretin. Thus, the secretin-induced increments in bile flow, biliary [HCO-3] and biliary HCO-3 output averaged 58.2+/-13.6 μl.min-1.kg-1, 16.6+/-3.1 mM and 5.3+/-1.4 μmol.min-1.kg-1 in vehicle-pretreated controls and 78.4+/-12.0 μl.min-1.kg-1, 16.1+/-2.7 mM and 5.1+/-0.5 μmol.min-1.kg-1 in colchicine-pretreated animals (all p values=n.s), respectively. This suggests that, at least in the rat model used, microtubule-dependent mechanisms are involved in basal, bile acid independent canalicular, but not in secretin-induced ductular, bile formation. Inasmuch as microtubule-dependent mechanisms are required for vesicle movement, this argues strongly against an absolute requirement for exocytic vesicle insertion in the ductular choleresis induced by secretin.

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참고문헌 (39)

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DOI : 10.1016/0168-8278(95)80288-6
European Association for the Study of the Liver : 저널
Elsevier : 저널 > 논문

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[해외논문] Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertion

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