[논문]Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertion

Dallenbach, A.; Renner, E.L.

doi:10.1016/0168-8278(95)80288-6

[해외논문] Colchicine does not inhibit secretin-induced choleresis in rats exhibiting hyperplasia of bile ductules: evidence against a pivotal role of exocytic vesicle insertion

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.22 no.3, 1995년, pp.338 - 348

Dallenbach, A. , Renner, E.L.

Abstract ▼ AI-Helper

Based on studies in the pig, secretin choleresis has been proposed to be initiated by colchicine-inhibitable, exocytic insertion into the basolateral cholangiocyte membrane of intracytoplasmatic vesicles containing a H+ ATPase. Formal prof of this hypothesis in the intact liver of other species, however, is lacking. The effect of the microtubule inhibitor colchicine on the ductular bile formation and HCO-3 secretion induced by secretin was, therefore, explored in a secretin-responsive rat model characterized by marked hyperplasia of bile ductules. While colchicine pretreatment significantly decreased basal bile flow from 142.1+/-8.8 to 83.4+/-8.2 μl. min-1.kg-1 (p<0.001) and basal biliary erythritol clearance from 112.7+/-6.3 to 69.9+/-7.0 μl.min-1. kg-1 (ps0.05), it did not significantly affect basal biliary [HCO-3], nor basal biliary bile acid output. Moreover, colchicine did not alter the effects of secretin. Thus, the secretin-induced increments in bile flow, biliary [HCO-3] and biliary HCO-3 output averaged 58.2+/-13.6 μl.min-1.kg-1, 16.6+/-3.1 mM and 5.3+/-1.4 μmol.min-1.kg-1 in vehicle-pretreated controls and 78.4+/-12.0 μl.min-1.kg-1, 16.1+/-2.7 mM and 5.1+/-0.5 μmol.min-1.kg-1 in colchicine-pretreated animals (all p values=n.s), respectively. This suggests that, at least in the rat model used, microtubule-dependent mechanisms are involved in basal, bile acid independent canalicular, but not in secretin-induced ductular, bile formation. Inasmuch as microtubule-dependent mechanisms are required for vesicle movement, this argues strongly against an absolute requirement for exocytic vesicle insertion in the ductular choleresis induced by secretin.

Keyword

참고문헌 (39)

J Clin Invest Boyer 54 773 1974 10.1172/JCI107817 Canalicular bile secretion in man. Studies utilizing biliary clearance of [14C]mannitol

상세보기
Gastroenterology Buanes 95 417 1988 10.1016/0016-5085(88)90499-4 Secretin empties bile duct cell cytoplasm of vesicles when it initiates ductular HCO？3 secretion in the pig

상세보기
Gastroenterology Jones 60 64 1971 10.1016/S0016-5085(71)80007-0 The choleretic effects of glucagon and secretin in the dog

상세보기
Am J Physiol Wheeler 210 1153 1966 10.1152/ajplegacy.1966.210.5.1153 Role of bile ducts during secretin choleresis in dogs

상세보기
Am J Physiol Lenzen 262 G527 1992 Secretin stimulates bile ductular secretory activity through the cAMP system
Am J Physiol Blot-Chabaud 258 G863 1990 Effect of acid-base balance on bilitary bicarbonate secretion in the isolated perfused guinea pig liver
J Clin Invest Strazzabosco 87 1503 1991 10.1172/JCI115160 Intracellular pH regulation in isolated rat bile duct eipthelial cells

상세보기
Am J Physiol Villanger 265 G719 1993 Secretin causes H+ secretion from intrahepatic bile ductules by vacuolar-type H+ ATPase
Acta Physiol Scand Veel 139 603 1990 10.1111/j.1748-1716.1990.tb08965.x Colchicine blocks the effects of secretin on bile duct cell tubulovesicles and plasma membrane geometry and impairs ductular HCO？3 secretion in the pig

상세보기
J Biol Chem Kato 267 15523 1992 10.1016/S0021-9258(19)49566-5 Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism

상세보기
Am J Physiol McGill 262 G703 1992 Characterization of high-conductance anion channels in rat bile duct epithelial cells
Gastroenterology Cohn 105 1857 1993 10.1016/0016-5085(93)91085-V Location of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells

상세보기
J Clin Invest Fitz 91 319 1993 10.1172/JCI116188 Regulation of membrane Cl？ currents in rat bile duct epithelial cells

상세보기
Am J Physiol Alpini 257 G124 1989 Bile secretory function of intrahepatic biliary epithelium in the rat
Hepatology Saucan 15 714 1991 10.1002/hep.1840150427 Differential colchicine effects on the transport of membrane and secretory proteins in rat hepatocytes in vivo: bipolar secretion of albumin

상세보기
Gastroenterology Goldman 85 130 1983 10.1016/S0016-5085(83)80239-X Hepatocyte handling of immunoglobulin A in the rat: the role of microtubules

상세보기
Gastroenterology Kacich 85 385 1983 10.1016/0016-5085(83)90328-1 Effects of cytochalasin D and colchicine on the uptake, translocation, and biliary secretion of horseradish peroxidase and [14C]sodium taurocholate in the rat

상세보기
Gastroenterology Dubin 79 646 1980 10.1016/0016-5085(80)90239-5 Influence of colchicine and phalloidin on bile secretion and hepatic ultrastructure in the rat. Possible interactions between microtubules and microfilaments

상세보기
Gastroenterology Knuchel 97 950 1989 10.1016/0016-5085(89)91503-5 Effect of secretin in bile formation in rats with cirrhosis of the liver: structure-function relationship

상세보기
Naunyn-Schmiedebergs Arch Pharmacol Paumgartner 270 98 1971 10.1007/BF00997305 Effect of phenobarbital on bile flow and bile salt excretion in the rat

상세보기
Gastroenterology Alpini 97 1248 1989 10.1016/0016-5085(89)91696-X Isolation of a nonparenchymal liver cell fraction enriched in cells with biliary epithelial phenotypes

상세보기
J Clin Invest Alpini 81 569 1988 10.1172/JCI113355 Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules

상세보기
Naunyn-Schmiedebergs Arch Pharmacol Paumgartner 285 165 1974 10.1007/BF00501151 Taurocholate excretion and bile formation in the isolated perfused rat liver. An in vitro-in vivo comparison

상세보기
Am J Physiol Berthelot 219 809 1970 10.1152/ajplegacy.1970.219.3.809 Mechanisms of phenobarbital-induced hypercholeresis in the rat

상세보기
J Lab Clin Invest Balabaud 89 393 1977 The assessment of the bile salt-nondependent fraction of canalicular bile water in the rat
Biochem J Lowe 229 529 1985 10.1042/bj2290529 Transcytosis and paracellular movements of horseradish peroxidase across liver parenchymal tissue from blood to bile

상세보기
AM J Physiol Bruck 265 G347 1993 Intracellular alkalinization stimulates bile flow and vesicular-mediated exocytosis in IPRL
Hepatology Thomas 5 207 1985 10.1002/hep.1840050208 The effects of colchicine and vinblastin on the biliary excretion of carcinoembryonic antigen

상세보기
Gastroenterology Tavoloni 94 217 1988 10.1016/0016-5085(88)90633-6 Biliary clearance of inert carbohydrates. Expectations and reality

상세보기
Am J Physiol Hardison 235 E158 1978 Importance of bicarbonate in bile salt independent fraction of bile flow
J Clin Invest Van Dyke 70 505 1982 10.1172/JCI110642 Effects of ion substitution on bile acid-dependent and -independent bile formation by rat liver

상세보기
Am J Physiol Answer 244 G116 1983 Role of inorganic electrolytes in bile acid-independent canalicular bile formation
Am J Physiol Ballatori 256 G22 1989 Relation between biliary glutathion excretion and bile acid-independent bile flow
Am J Physiol Ballatori 263 G617 1992 Glutathion as a primary osmotic driving force in hepatic bile formation
J. Clin Invest Meier 75 1256 1985 10.1172/JCI111824 Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles

상세보기
Am J Physiol Oude Elfering 258 G699 1990 ATP-dependent efflux of GSSG and GSH-conjugate from isolated rat hepatocytes
Am J Physiol Nishida 262 G629 1992 ATP-dependent organic anion transport system in normal and TR-rat liver canalicular membranes
Hepatology Oude Elferink 17 434 1993 10.1016/0270-9139(93)90056-S Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific anion transporter

상세보기
Hepatology Alpini 18 109A 1993 10.1016/0270-9139(93)91963-S Morphologic and functional heterogeneity of intrahepatic bile duct epithelial cells from normal rat liver [Abstract]

상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 논문

해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

원문 URL 링크

DOI : 10.1016/0168-8278(95)80288-6
European Association for the Study of the Liver : 저널
Elsevier : 저널 > 논문

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

저작권 관리 안내

내보내기 메뉴

내보내기 구분

파일저장
인쇄
메일전송

구성항목

기본정보
상세정보

관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관

저장형식

Text(ASCII format)
Excel format
RefWorks Direct Export
RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley

메일정보

받는사람 (필수): @
보내는사람 (선택): @
제목
내용: KISTI 검색결과 이메일 서비스

안내

총 건의 자료가 검색되었습니다.

다운받으실 자료의 인덱스를 입력하세요. (1-10,000)

검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다.

데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요)

다운로드 파일은 UTF-8 형태로 저장됩니다.
파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오.

Text(ASCII format)
Excel format

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

AI-Helper ※ AI-Helper는 을 사용합니다.

AI-Helper

안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

연합인증