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Cell, v.92 no.4, 1998년, pp.523 - 533
Clandinin, Thomas R (Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , DeModena, John A (Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Sternberg, Paul W (Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California 91125, USA)
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AbstractActivity of LET-23, the C. elegans homolog of the epidermal growth factor receptor, is required in multiple tissues. RAS activation is necessary and sufficient for certain LET-23 functions. We show that an inositol trisphosphate receptor can act as a RAS-independent, tissue-specific positive...
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