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Cell, v.93 no.3, 1998년, pp.361 - 372
Yao, Tso-Pang (Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA) , Oh, Suk P (Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA) , Fuchs, Miriam (Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA) , Zhou, Nai-Dong (Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA) , Ch'ng, Lian-Ee (Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA) , Newsome, David (Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA) , Bronson, Roderick T (Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, Boston, Massachusetts 02111, USA) , Li, En (Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA) , Livingston, David M (Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA) , Eckner, Richard (Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachus)
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AbstractThe transcriptional coactivator and integrator p300 and its closely related family member CBP mediate multiple, signal-dependent transcriptional events. We have generated mice lacking a functional p300 gene. Animals nullizygous for p300 died between days 9 and 11.5 of gestation, exhibiting d...
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