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Cell, v.93 no.4, 1998년, pp.519 - 529
Conradt, Barbara (Department of Biology, Howard Hughes Medical Institute, 68-425, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA) , Horvitz, H.Robert (Department of Biology, Howard Hughes Medical Institute, 68-425, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)
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AbstractGain-of-function mutations in the Caenorhabditis elegans gene egl-1 cause the HSN neurons to undergo programmed cell death. By contrast, a loss-of-function egl-1 mutation prevents most if not all somatic programmed cell deaths. The egl-1 gene negatively regulates the ced-9 gene, which protec...
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