[논문]MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis

Vazquez-Garcia, M.N.; Alaez, C.; Olivo, A.; Debaz, H.; Perez-Luque, E.; Burguete, A.; Cano, S.; de la Rosa, G.; Bautista, N.; Hernandez, A.; Bandera, J.; Torres, L.F.; Kershenobich, D.; Alvarez, F.; Gorodezky, C.

doi:10.1016/S0168-8278(98)80347-4

[해외논문] MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.28 no.6, 1998년, pp.985 - 990

Vazquez-Garcia, M.N. (Department of Immunogenetics, Instituto Nacional de Diagnostico y Referencia Epidemiologicos, SSA,, , Mexico) , Alaez, C. , Olivo, A. , Debaz, H. , Perez-Luque, E. , Burguete, A. , Cano, S. , de la Rosa, G. , Bautista, N. , Hernandez, A. , Bandera, J. , Torres, L.F. , Kershenobich, D. , Alvarez, F. , Gorodezky, C.

Abstract ▼ AI-Helper

Background/Aims: Autoimmune hepatitis has a genetic background associated with different HLA DRB1 alleles depending on the ethnic group. The aim of this study was to analyse the immunogenetics of type I autoimmune hepatitis in Mexicans.Methods: Thirty Mexican Mestizo patients and 175 healthy controls were HLA typed as follows: class I antigens were determined by microlymphocytotoxicity and class II typing was done on DNA samples using PCR-SSO and PCR-SSP for DRB1, DQA1 and DQB1 loci.Results: A significant association of autoimmune hepatitis with DRB1*0404 was found, (χ2Y=19.95, pc=0.002, RR=7.71), suggesting the presence of a susceptibility gene located at the DRB1 locus. Resistance was at least partially due to a DQB1 gene, since a significant decrease in DQB1*0301 was also detected (χ2Y=8.21, pc=0.04). Analysis of subgroups according to age at onset showed an association with DBR1*0404 (χ2Y=4.31, p=0.04) in patients with late onset (after 30 years), while DQA1*0501 (χ2Y=5.12, p=0.02) was increased in the early onset group.Conclusions: The possible mechanism of HLA association is due to ''shared epitopes'', since DRB1*0404, and those found in other populatios namely, DRB1*0401, *0405 and *0301 share almost the same sequence at position 67-72 (LLEQRR, R or K at 71). Valine-86 is also relevant to the age at onset because DRB1*0404 is increased in the patients with an average age at onset of 32. These findigs are relevant in determining which peptides in the liver are targets for T cells.

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DOI : 10.1016/S0168-8278(98)80347-4
European Association for the Study of the Liver : 저널
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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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