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Neuron, v.21 no.6, 1998년, pp.1339 - 1351
Chiesa, R. (Department of Cell Biology and, Physiology, Washington University, School of Medicine, , Missouri 63110,, St. Louis, USA) , Piccardo, P. , Ghetti, B. , Harris, D.A.
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Familial prion diseases are caused by mutations in the gene encoding the prion protein (PrP). We have produced transgenic mice that express the mouse homolog of a mutant human PrP containing a nine octapeptide insertion associated with prion dementia. These mice exhibit a slowly progressive neurolog...
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