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Cell, v.96 no.1, 1999년, pp.89 - 98
England, Pamela M. (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Zhang, Yinong (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Dougherty, Dennis A. (Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA) , Lester, Henry A. (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA)
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AbstractAn approach to identify backbone conformational changes underlying nicotinic acetylcholine receptor (nAChR) gating was developed. Specific backbone peptide bonds were replaced with an ester, which disrupts backbone hydrogen bonds at the site of mutation. At a conserved proline residue (...
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