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Cell, v.96 no.1, 1999년, pp.89 - 98
England, Pamela M. (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Zhang, Yinong (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Dougherty, Dennis A. (Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA) , Lester, Henry A. (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA)
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AbstractAn approach to identify backbone conformational changes underlying nicotinic acetylcholine receptor (nAChR) gating was developed. Specific backbone peptide bonds were replaced with an ester, which disrupts backbone hydrogen bonds at the site of mutation. At a conserved proline residue (...
J. Membr. Biol. Adams 58 161 1981 10.1007/BF01870902 Acetylcholine receptor kinetics
Neuron Akabas 13 919 1994 10.1016/0896-6273(94)90257-7 Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit
Biochemistry Akabas 34 12496 1995 10.1021/bi00039a002 Identification of acetylcholine receptor channel-lining residues in the M1 segment of the α-subunit
J. Physiol. (Lond.) Anderson 235 655 1973 10.1113/jphysiol.1973.sp010410 Voltage-clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction
J. Physiol. Auerbach 49 155 1996 10.1113/jphysiol.1996.sp021482 Voltage dependence of mouse acetylcholine receptor gating
J. Mol. Biol. Barlow 201 601 1988 10.1016/0022-2836(88)90641-9 Helix geometry in proteins
Proc. Natl. Acad. Sci. USA Brandl 83 917 1986 10.1073/pnas.83.4.917 Hypothesis about the function of membrane-buried proline residues in transport proteins
J. Am. Chem. Soc. Chapman 119 7151 1997 10.1021/ja970826+ Mutational analysis of backbone hydrogen bonds in staphylococcal nuclease
Neuron Charnet 2 87 1990 10.1016/0896-6273(90)90445-L An open-channel blocker interacts with adjacent turns of α-helices in the nicotinic acetylcholine receptor
Proc. R. Soc. Lond. B. Biol. Sci. Colquhoun 199 231 1981 10.1098/rspb.1977.0137 Relaxations and fluctuations of membrane currents that flow through drug operated channels
Neuroreport Devillers-Thiery 3 1001 1992 10.1097/00001756-199211000-00014 Stratified organization of the nicotinic acetylcholine receptor channel
Science Doyle 280 69 1998 10.1126/science.280.5360.69 The structure of the potassium channel
Adv. Protein Chem. Edelstein 51 121 1998 10.1016/S0065-3233(08)60652-X Allosteric transitions of the acetylcholine receptor
Science Ellman 255 197 1992 10.1126/science.1553546 Site-specific incorporation of novel backbone structures into proteins
Mol. Pharmacol. Filatov 48 379 1995 The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
J. Biol. Chem. Herz 264 12439 1989 10.1016/S0021-9258(18)63878-5 Distance between the agonist and noncompetitive inhibitor sites on the nicotinic acetylcholine receptor
Biochemistry Ivanina 33 8786 1994 10.1021/bi00195a021 Phosphorylation by protein kinase A of RCK1 K+ channels expressed in Xenopus oocytes
Neuron Karlin 15 1231 1995 10.1016/0896-6273(95)90004-7 Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins
Mol. Pharmacol. Kearney 50 1401 1996 Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor
Neuron Kearney 17 1221 1996 10.1016/S0896-6273(00)80252-4 Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9′ position
Biochemistry Koh 36 11314 1997 10.1021/bi9707685 An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis
Nature Labarca 376 514 1995 10.1038/376514a0 Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
Lide 1990 Handbook of Chemistry and Physics, 71st ed
J. Physiol. Magleby 223 151 1972 10.1113/jphysiol.1972.sp009839 The effect of voltage on the time course of end-plate currents
J. Physiol. Magleby 223 173 1972 10.1113/jphysiol.1972.sp009840 A quantitative description of end-plate currents
Proc. Natl. Acad. Sci. USA Neher 72 2140 1975 10.1073/pnas.72.6.2140 Voltage-dependence of drug-induced conductance in frog neuromuscular junction
Science Noren 244 182 1989 10.1126/science.2649980 A general method for site-specific incorporation of unnatural amino acids into proteins
Science Nowak 268 439 1995 10.1126/science.7716551 Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells
Methods Enzymol. Nowak 293 504 1998 10.1016/S0076-6879(98)93031-2 In vivo incorporation of unnatural amino acids into ion channels in a Xenopus oocyte expression system
Nature Revah 353 846 1991 10.1038/353846a0 Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor
J. Biol. Chem. Saks 271 23169 1996 10.1074/jbc.271.38.23169 An engineered Tetrahymena tRNAGln for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression
Int. J. Pept. Protein Res. Sankararamakrishnan 39 356 1992 10.1111/j.1399-3011.1992.tb01595.x Geometry of proline-containing α-helices in proteins
J. Gen. Physiol. Sheridan 70 187 1977 10.1085/jgp.70.2.187 Rates and equilibria at the acetylcholine receptor of Electrophorus electroplaques. A study of neurally evoked postsynaptic currents and of voltage-jump relaxations
Neuron Sine 15 229 1995 10.1016/0896-6273(95)90080-2 Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity
J. Mol. Biol. Unwin 229 1101 1993 10.1006/jmbi.1993.1107 Nicotinic acetylcholine receptor at 9-A resolution
Nature Unwin 373 37 1995 10.1038/373037a0 Acetylcholine receptor channel imaged in the open state
J. Gen. Physiol. Wang 109 757 1997 10.1085/jgp.109.6.757 Mutation in the M1 domain of the acetylcholine receptor α subunit decreases the rate of agonist dissociation
Neuron Wilson 20 1269 1998 10.1016/S0896-6273(00)80506-1 The location of the gate in the acetylcholine receptor channel
Crit. Rev. Biochem. Mol. Biol. Yaron 28 31 1993 10.3109/10409239309082572 Proline-dependent structural and biological properties of peptides and proteins
Biochemistry Zhang 36 15856 1997 10.1021/bi972357u Identification of acetylcholine receptor channel-lining residues in the M1 segment of the β-subunit
Proc. Natl. Acad. Sci. USA Zhong 95 12088 1998 10.1073/pnas.95.21.12088 From ab initio quantum mechanics to molecular neurobiology
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