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Cell, v.94 no.6, 1998년, pp.739 - 750
Yoshida, H. , Kong, Y.Y. , Yoshida, R. , Elia, A.J. , Hakem, A. , Hakem, R. , Penninger, J.M. , Mak, T.W.
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Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian homolog of C. elegans CED-4, was investigated in gene-targeted Apaf1-/- mice. Apaf1-deficient mice exhibited reduced apoptosis in the brain and striking craniofacial abno...
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