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[해외논문] Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development 원문보기

Cell, v.94 no.6, 1998년, pp.739 - 750  

Yoshida, H. ,  Kong, Y.Y. ,  Yoshida, R. ,  Elia, A.J. ,  Hakem, A. ,  Hakem, R. ,  Penninger, J.M. ,  Mak, T.W.

Abstract AI-Helper 아이콘AI-Helper

Apoptosis is essential for the precise regulation of cellular homeostasis and development. The role in vivo of Apaf1, a mammalian homolog of C. elegans CED-4, was investigated in gene-targeted Apaf1-/- mice. Apaf1-deficient mice exhibited reduced apoptosis in the brain and striking craniofacial abno...

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