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[해외논문] Mammalian Telomeres End in a Large Duplex Loop 원문보기

Cell, v.97 no.4, 1999년, pp.503 - 514  

Griffith, Jack D (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, and Curriculum in Genetics and Molecular Biology, Chapel Hill, North Carolina 27599-7295, USA) ,  Comeau, Laurey (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, and Curriculum in Genetics and Molecular Biology, Chapel Hill, North Carolina 27599-7295, USA) ,  Rosenfield, Soraya (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, and Curriculum in Genetics and Molecular Biology, Chapel Hill, North Carolina 27599-7295, USA) ,  Stansel, Rachel M (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, and Curriculum in Genetics and Molecular Biology, Chapel Hill, North Carolina 27599-7295, USA) ,  Bianchi, Alessandro (The Rockefeller University, New York, New York 10021, USA) ,  Moss, Heidi (The Rockefeller University, New York, New York 10021, USA) ,  de Lange, Titia (The Rockefeller University, New York, New York 10021, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractMammalian telomeres contain a duplex array of telomeric repeats bound to the telomeric repeat–binding factors TRF1 and TRF2. Inhibition of TRF2 results in immediate deprotection of chromosome ends, manifested by loss of the telomeric 3′ overhang, activation of p53, and end-to-e...

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