Fabris, Paolo
(Paolo Fabris, Department of Infectious Diseases, Ospedale S. Bortolo, Viale Rodolfi, 36100 - Vicenza, Italy. Tel: 39 444 993998. Fax: 39 444 993616.)
,
Biasin, Maria Raffaella
(Department of Pathology, Hospital of Castelfranco Veneto, Treviso, Italy)
,
Infantolino, Domenico
(Department of Pathology, Hospital of Castelfranco Veneto, Treviso, Italy)
,
Tositti, Giulia
(Department of Infectious Diseases, Ospedale S. Bortolo, Vicenza, Italy)
,
Venza, Enzo
(Department of Pathology, Hospital of Castelfranco Veneto, Treviso, Italy)
,
Floreani, Annarosa
(Department of Gastroenterology, University of Padova, Padova, Italy)
,
Zanetti, Alessandro
(Institute of Virology, University of Milan, Milan, Italy)
,
Lalla, Fausto de
(Department of Infectious Diseases, Ospedale S. Bortolo, Vicenza, Italy)
AbstractBackground/Aims: Recently, the presence of a novel nonenveloped single-stranded DNA virus (TTV) has been associated with either acute or chronic hepatitis of unknown aetiology, suggesting a possible aetiological role. The aim of this study was to evaluate the prevalence, the significance and...
AbstractBackground/Aims: Recently, the presence of a novel nonenveloped single-stranded DNA virus (TTV) has been associated with either acute or chronic hepatitis of unknown aetiology, suggesting a possible aetiological role. The aim of this study was to evaluate the prevalence, the significance and the clinical impact of TTV infection in patients with acute viral hepatitis of defined aetiology and in patients with non-A-E acute hepatitis.Methods: TTV-DNA was tested by hemi-nested PCR in serum samples collected from 121 patients during and after acute hepatitis (103 with acute viral hepatitis of defined aetiology and 18 with acute non-A-E hepatitis) and in 30 healthy controls.Results: Overall, the rate of TTV infection was 12.6% (13/103) in patients with acute hepatitis of defined aetiology, 16.6% (3/18) in patients with non-A-E acute hepatitis and 6.6% (2/30) in the healthy control group, (p=n.s). TTV-DNA was detected in the following proportions: hepatitis B, 13.2% (7/53); hepatitis C, 16.6% (4/24); hepatitis A, 4.7% (1/21); hepatitis E 20% (1/5). Moreover, acute hepatitis with and without TTV infection/coinfection were comparable in terms of both liver biochemistry and chronicity rate. The results of TTV re-testing after serial dilutions of six TTV-DNA positive serum samples during and after the peak of liver transaminases failed to demonstrate a correlation between liver damage and viral titre.Conclusions: The prevalence of TTV infection appeared to be comparable in patients with non-A-E hepatitis, in acute hepatitis of defined aetiology and in the control group. Hence, an aetiological role of TTV for acute hepatitis of unknown aetiology seems questionable. Moreover, TTV infection does not modify the natural history of acute hepatitis of defined aetiology.
AbstractBackground/Aims: Recently, the presence of a novel nonenveloped single-stranded DNA virus (TTV) has been associated with either acute or chronic hepatitis of unknown aetiology, suggesting a possible aetiological role. The aim of this study was to evaluate the prevalence, the significance and the clinical impact of TTV infection in patients with acute viral hepatitis of defined aetiology and in patients with non-A-E acute hepatitis.Methods: TTV-DNA was tested by hemi-nested PCR in serum samples collected from 121 patients during and after acute hepatitis (103 with acute viral hepatitis of defined aetiology and 18 with acute non-A-E hepatitis) and in 30 healthy controls.Results: Overall, the rate of TTV infection was 12.6% (13/103) in patients with acute hepatitis of defined aetiology, 16.6% (3/18) in patients with non-A-E acute hepatitis and 6.6% (2/30) in the healthy control group, (p=n.s). TTV-DNA was detected in the following proportions: hepatitis B, 13.2% (7/53); hepatitis C, 16.6% (4/24); hepatitis A, 4.7% (1/21); hepatitis E 20% (1/5). Moreover, acute hepatitis with and without TTV infection/coinfection were comparable in terms of both liver biochemistry and chronicity rate. The results of TTV re-testing after serial dilutions of six TTV-DNA positive serum samples during and after the peak of liver transaminases failed to demonstrate a correlation between liver damage and viral titre.Conclusions: The prevalence of TTV infection appeared to be comparable in patients with non-A-E hepatitis, in acute hepatitis of defined aetiology and in the control group. Hence, an aetiological role of TTV for acute hepatitis of unknown aetiology seems questionable. Moreover, TTV infection does not modify the natural history of acute hepatitis of defined aetiology.
Biochem Biophys Res Commun Nishizawa 241 92 1997 10.1006/bbrc.1997.7765 A novel DNA virus (TTV) associated with elevated transaminases levels in postransfusion hepatitis of unknown aetiology
Hepatol Res Okamoto 10 1 1998 10.1016/S1386-6346(97)00123-X Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttrasfusion hepatitis of unknown aetiology
Hepatology Charlton 28 839 1998 10.1002/hep.510280335 TT-virus infection in north american blood donors, patients with fulminant hepatic failure and cryptogenic cirrhosis
J Gastroenterol Fabris 33 57 1998 10.1007/PL00009967 HGV/GBV-c infection in patients with acute hepatitis of different aetiology and in patients with chronic hepatitis C
J Med Virol Zanetti 57 356 1999 10.1002/(SICI)1096-9071(199904)57:4<356::AID-JMV5>3.0.CO;2-D Hepatitis E virus in patients with acute non A-C hepatitis in Italy: identification of a novel variant
J Hepatol Ikeda 30 205 1999 10.1016/S0168-8278(99)80063-4 Infection with an unenveloped DNA virus (TTV) in patients with acute or chronic liver disease of unknown aetiology and in those positive for hepatitis C virus RNA
Hepatology Villano 29 908 1999 10.1002/hep.510290311 Persistence of viremia and the importance of long-term follow-up after acute hepatitis C infection
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