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NTIS 바로가기Cell, v.101 no.1, 2000년, pp.91 - 101
Ollmann, Michael (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Young, Lynn M (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Di Como, Charles J (Department of Biological Sciences, Columbia University, New York, New York 10027, USA) , Karim, Felix (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Belvin, Marcia (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Robertson, Stephanie (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Whittaker, Kellie (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Demsky, Madelyn (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Fisher, William W (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Buchman, Andrew (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Duyk, Geoffrey (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, California 94080, USA) , Friedman, Lori (Exelixis, Inc., 260 Littlefield Avenue, South San Francisco, C) , Prives, Carol , Kopczynski, Casey
Abstract The importance of p53 in carcinogenesis stems from its central role in inducing cell cycle arrest or apoptosis in response to cellular stresses. We have identified a Drosophila homolog of p53 (“Dmp53”). Like mammalian p53, Dmp53 binds specifically to human p53 binding si...
Trends Cell Biol. Abrams 9 435 1999 10.1016/S0962-8924(99)01646-3 An emerging blueprint for apoptosis in Drosophila
Development Abrams 117 29 1993 10.1242/dev.117.1.29 Programmed cell death during Drosophila embryogenesis
Nature Agami 399 809 1999 10.1038/21697 Interaction of c-Abl and p73α and their collaboration to induce apoptosis
Proc. Natl. Acad. Sci. USA Agarwal 92 8493 1995 10.1073/pnas.92.18.8493 p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
J. Mol. Biol. Altschul 215 403 1990 10.1016/S0022-2836(05)80360-2 Basic local alignment search tool
EMBO J. Asada 18 1223 1999 10.1093/emboj/18.5.1223 Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation
Exp. Cell Res. Barker 232 240 1997 10.1006/excr.1997.3513 Detection of mutant p53 in clam leukemia cells
Genet. Barlow 17 453 1997 Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways Nat
Cell Death Differ. Beumer 5 669 1998 10.1038/sj.cdd.4400396 The role of the tumor suppressor p53 in spermatogenesis
Oncogene Bissonnette 16 3461 1998 10.1038/sj.onc.1201899 p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage
Proc. Natl. Acad. Sci. USA Brachmann 93 4091 1996 10.1073/pnas.93.9.4091 Dominant-negative p53 mutations selected in yeast hit cancer hot spots
Genes Dev. Brodsky in press 2000 mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development
Cell Brodsky 101 103 2000 10.1016/S0092-8674(00)80627-3 Drosophila p53 binds a damage response element at the reaper locus
Nature Buckbinder 377 646 1995 10.1038/377646a0 Induction of the growth inhibitor IGF-binding protein 3 by p53
J. Assist. Reprod. Genet. Bukovsky 12 123 1995 10.1007/BF02211381 Expression of cell cycle regulatory proteins (p53, pRb) in the human female genital tract
Genes Dev. Chehab 14 278 2000 10.1101/gad.14.3.278 Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
Science Cho 265 346 1994 10.1126/science.8023157 Crystal structure of a p53 tumor suppressor-DNA complex
Science Clore 265 386 1994 10.1126/science.8023159 High-resolution structure of the oligomerization domain of p53 by multidimensional NMR
Science de Nooij 270 983 1995 10.1126/science.270.5238.983 Uncoupling cell fate determination from patterned cell division in the Drosophila eye
Cell de Nooij 87 1237 1996 10.1016/S0092-8674(00)81819-X A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
Cell Deng 82 675 1995 10.1016/0092-8674(95)90039-X Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Oncogene Di Como 16 2527 1998 10.1038/sj.onc.1202041 Human tumor-derived p53 proteins exhibit binding site selectivity and temperature sensitivity for transactivation in a yeast-based assay
Mol. Cell. Biol. Di Como 19 1438 1999 10.1128/MCB.19.2.1438 p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
Genes Dev. Du 10 1206 1996 10.1101/gad.10.10.1206 RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila
Science Edgar 274 1646 1996 10.1126/science.274.5293.1646 Developmental control of cell cycle regulators
Cell el-Deiry 75 817 1993 10.1016/0092-8674(93)90500-P WAF1, a potential mediator of p53 tumor suppression
Science Elledge 274 1664 1996 10.1126/science.274.5293.1664 Cell cycle checkpoints
Curr. Biol. Fogarty 7 418 1997 10.1016/S0960-9822(06)00189-8 The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity
Genes Dev. Giaccia 12 2973 1998 10.1101/gad.12.19.2973 The complexity of p53 modulation
Nature Gong 399 806 1999 10.1038/21690 The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
Oncogene Gorospe 14 929 1997 10.1038/sj.onc.1200897 p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells
Biochim. Biophys. Acta Gottlieb 1287 77 1996 p53 in growth control and neoplasia
Nature Graeber 379 88 1996 10.1038/379088a0 Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Curr. Biol. Hall 7 R144 1997 10.1016/S0960-9822(97)70074-5 Tumor suppressors
Cell Hari 82 815 1995 10.1016/0092-8674(95)90478-6 The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene
Cell Harper 75 805 1993 10.1016/0092-8674(93)90499-G The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
Development Hay 120 2121 1994 10.1242/dev.120.8.2121 Expression of baculovirus P35 prevents cell death in Drosophila
Cell Hupp 71 875 1992 10.1016/0092-8674(92)90562-Q Regulation of the specific DNA binding function of p53
Science Jeffrey 267 1498 1995 10.1126/science.7878469 Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
Oncogene Kaelin 18 7701 1999 10.1038/sj.onc.1202955 The p53 gene family
Cell Kaghad 90 809 1997 10.1016/S0092-8674(00)80540-1 Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
Proc. Natl. Acad. Sci. USA Kamijo 95 8292 1998 10.1073/pnas.95.14.8292 Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
Cell Kastan 71 587 1992 10.1016/0092-8674(92)90593-2 A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Nature Kinzler 379 19 1996 10.1038/379019a0 Life (and death) in a malignant tumour
Genes Dev. Ko 10 1054 1996 10.1101/gad.10.9.1054 p53
Science Kussie 274 948 1996 10.1126/science.274.5289.948 Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
Cell Lane 87 1225 1996 10.1016/S0092-8674(00)81818-8 Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development
Nat. Struct. Biol. Lee 1 877 1994 10.1038/nsb1294-877 Solution structure of the tetrameric minimum transforming domain of p53
Protein Eng. Levin 10 771 1997 10.1093/protein/10.7.771 Exploring the limits of nearest neighbour secondary structure prediction
Cell Levine 88 323 1997 10.1016/S0092-8674(00)81871-1 p53, the cellular gatekeeper for growth and division
Mol. Cell. Biol. Liao 19 3095 1999 10.1128/MCB.19.4.3095 Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction
Genes Dev. Lin 8 1235 1994 10.1101/gad.8.10.1235 Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
Curr. Opin. Oncol. Lowe 7 547 1995 10.1097/00001622-199511000-00013 Cancer therapy and p53
Trends Genet. McCall 13 222 1997 10.1016/S0168-9525(97)01126-8 Facing death in the fly
Cell Miyashita 80 293 1995 10.1016/0092-8674(95)90412-3 Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
J. Cell. Physiol. Nevins 173 233 1997 10.1002/(SICI)1097-4652(199711)173:2<233::AID-JCP27>3.0.CO;2-F Role of the Rb/E2F pathway in cell growth control
Nat. Genet. Nicol 10 181 1995 10.1038/ng0695-181 A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice
Nat. Med. Norimura 2 577 1996 10.1038/nm0596-577 p53-dependent apoptosis suppresses radiation-induced teratogenesis
Mol. Cell. Biol. Owen-Schaub 15 3032 1995 10.1128/MCB.15.6.3032 Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
Nature Polyak 389 300 1997 10.1038/38525 A model for p53-induced apoptosis
J. Virol. Prikhod'ko 73 1227 1999 10.1128/JVI.73.2.1227-1234.1999 Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis
J. Pathol. Prives 187 112 1999 10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3 The p53 pathway
Mol. Hum. Reprod. Quenby 5 737 1999 10.1093/molehr/5.8.737 Oncogenes and tumour suppressor genes in first trimester human fetal gonadal development
Mol. Cell. Biol. Sabbatini 15 1060 1995 10.1128/MCB.15.2.1060 Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
J. Mol. Biol. Sali 234 779 1993 10.1006/jmbi.1993.1626 Comparative protein modelling by satisfaction of spatial restraints
10.1002/(SICI)1097-0134(1997)1+<50::AID-PROT8>3.0.CO;2-S Sanchez, R., and Sali, A. (1997). Evaluation of comparative protein structure modeling by MODELLER-3. Proteins Suppl. 1, 50-58.
Oncogene Schmale 15 1363 1997 10.1038/sj.onc.1201500 A novel protein with strong homology to the tumor suppressor p53
Proc. Natl. Acad. Sci. USA Shen 91 8940 1994 10.1073/pnas.91.19.8940 Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein
Genes Dev. Shieh 14 289 2000 10.1101/gad.14.3.289 The human homologoues of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
Oncogene Stewart 10 109 1995 Evidence for a second cell cycle block at G2/M by p53
Dev. Biol. Su 196 160 1998 10.1006/dbio.1998.8855 The cell cycle program in germ cells of the Drosophila embryo
Oncogene Suzuki 18 1239 1999 10.1038/sj.onc.1202409 Caspase 3 inactivation to suppress Fas-mediated apoptosis
Mol. Cell. Biol. Suzuki 19 3842 1999 10.1128/MCB.19.5.3842 Mitochondrial regulation of cell death
Dev. Biol. Tomlinson 120 264 1987 10.1016/0012-1606(87)90448-9 Cell fate in the Drosophila ommatidium
Mol. Mar. Biol. Biotechnol. Van Beneden 6 116 1997 Characterization of gene expression of a p53 homolog in the soft-shell clam (Mya arenaria)
Van Vactor, D., and Kopczynski, C. (1999). Anatomical Techniques for Analysis of Nervous System Development in the Drosophila Embryo, J.D. Richter, ed. (New York: Oxford University Press).
Cell Vogelstein 70 523 1992 10.1016/0092-8674(92)90421-8 p53 function and dysfunction
Genes Dev. Wagner 8 2817 1994 10.1101/gad.8.23.2817 Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1
Nature Waldman 381 713 1996 10.1038/381713a0 Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
Science Wang 273 359 1996 10.1126/science.273.5273.359 Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation
Development Wolff 113 841 1991 10.1242/dev.113.3.841 The beginning of pattern formation in the Drosophila compound eye
Nature Xiong 366 701 1993 10.1038/366701a0 p21 is a universal inhibitor of cyclin kinases
Oncogene Yamaguchi 18 6767 1999 10.1038/sj.onc.1203113 Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc
Dev. Biol. Yin 204 165 1998 10.1006/dbio.1998.9074 p53-mediated germ cell quality control in spermatogenesis
Mol. Cell Yu 2 581 1998 10.1016/S1097-2765(00)80157-4 Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase
Nature Yuan 399 814 1999 10.1038/21704 p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
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