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[해외논문] PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor) : Defective Regulation in Failing Hearts 원문보기

Cell, v.101 no.4, 2000년, pp.365 - 376  

Marx, Steven O (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Reiken, Steven (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Hisamatsu, Yuji (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Jayaraman, Thotalla (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Burkhoff, Daniel (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Rosemblit, Nora (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Marks, Andrew R (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractThe ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is the major source of calcium (Ca2+) required for cardiac muscle excitation-contraction (EC) coupling. The channel is a tetramer comprised of four type 2 RyR polypeptides (RyR2) and four FK506 binding pr...

참고문헌 (36)

  1. Circulation Beuckelmann 85 1046 1992 10.1161/01.CIR.85.3.1046 Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure 

  2. Nature Bezprozvanny 351 751 1991 10.1038/351751a0 Bell-shaped calcium response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum 

  3. Cardiovasc. Res. Bohm 28 1713 1994 10.1093/cvr/28.11.1713 cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium 

  4. Cell Brillantes 77 513 1994 10.1016/0092-8674(94)90214-3 Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein 

  5. N. Engl. J. Med. Bristow 307 205 1982 10.1056/NEJM198207223070401 Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts 

  6. J. Clin. Invest. Bristow 89 803 1992 10.1172/JCI115659 Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms 

  7. J. Biol. Chem. Cameron 272 27582 1997 10.1074/jbc.272.44.27582 FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine- proline (1400-1401) and anchors calcineurin to this FK506-like domain 

  8. EMBO J. Chen 16 3866 1997 10.1093/emboj/16.13.3866 Mechanism of TGFbeta receptor inhibition by FKBP12 

  9. Lancet 353 9 1999 10.1016/S0140-6736(98)11181-9 The cardiac insufficiency bisoprolol study II (CIBIS-II) 

  10. N. Engl. J. Med. Cohn 311 819 1984 10.1056/NEJM198409273111303 Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure 

  11. Basic Res. Cardiol. Fozzard 87 105 1992 Afterdepolarizations and triggered activity 

  12. Neuron Fraser 23 423 1999 10.1016/S0896-6273(00)80795-3 Modulation of ion channels 

  13. Circulation Frazier 89 2908 1994 10.1161/01.CIR.89.6.2908 First use of an untethered, vented electric left ventricular assist device for long-term support 

  14. J. Clin. Invest. Go 95 888 1995 10.1172/JCI117739 Differential regulation of two types of intracellular calcium release channels during end-stage heart failure 

  15. Science Gomez 276 800 1997 10.1126/science.276.5313.800 Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure 

  16. J. Biol. Chem. Hain 270 2074 1995 10.1074/jbc.270.5.2074 Phosphorylation modulates the function of the calcium release channel of sarcoplasmic reticulum from cardiac muscle 

  17. J. Biol. Chem. Jayaraman 267 9474 1992 10.1016/S0021-9258(19)50114-4 FK506 binding protein associated with the calcium release channel (Ryanodine Receptor) 

  18. Circ. Res. Kaftan 78 990 1996 10.1161/01.RES.78.6.990 Effects of rapamycin on ryanodine receptor/Ca2+-release channels from cardiac muscle 

  19. J. Cell Sci. Kapiloff 112 2725 1999 10.1242/jcs.112.16.2725 mAKAP 

  20. Cardiovasc. Res. Kirchhefer 42 254 1999 10.1016/S0008-6363(98)00296-X Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts 

  21. Am. J. Phys. Laflamme 277 H1841 1999 Gs and adenylyl cyclase in transverse tubules of heart 

  22. Circulation Levin 91 2717 1995 10.1161/01.CIR.91.11.2717 Reversal of chronic ventricular dilation in patients with end-stage cardiomyopathy by prolonged mechanical unloading 

  23. J. Biol. Chem. Lorenz 270 27531 1995 10.1074/jbc.270.46.27531 TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin 

  24. Eur. J. of Biochem. MacDougall 196 725 1991 10.1111/j.1432-1033.1991.tb15871.x Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban 

  25. Physiol. Rev. Marks 76 631 1996 10.1152/physrev.1996.76.3.631 Cellular functions of immunophilins 

  26. Science Marx 281 818 1998 10.1126/science.281.5378.818 Coupled gating between individual skeletal muscle Ca2+ release channels (ryanodine receptors) 

  27. J. Biol. Chem. McCartney 270 9327 1995 10.1074/jbc.270.16.9327 Cloning and characterization of A-kinase anchor protein 100 (AKAP100). A protein that targets A-kinase to the sarcoplasmic reticulum 

  28. Lancet 353 2001 1999 10.1016/S0140-6736(99)04440-2 Effect of metoprolol CR/XL in chronic heart failure 

  29. Circulation Morgan 81 suppl III 21 1990 Abnormal intracellular calcium handling 

  30. J. Cell Biol. Moschella 120 1137 1993 10.1083/jcb.120.5.1137 Inositol 1,4,5-trisphosphate receptor expression in cardiac myocytes 

  31. J. Mol. Cell. Cardiol. Neumann 29 265 1997 10.1006/jmcc.1996.0271 Increased expression of cardiac phosphatases in patients with end-stage heart failure 

  32. Eur. Heart J. Regitz-Zagrosek 15 Suppl D 7 1994 10.1093/eurheartj/15.suppl_D.7 Myocardial cyclic AMP and norepinephrine content in human heart failure 

  33. Science Valdivia 267 1997 1995 10.1126/science.7701323 Rapid adaptation of cardiac ryanodine receptors 

  34. Circulation Wang 96 2683 1997 10.1161/01.CIR.96.8.2683 Physical training alters the pathogenesis of pacing-induced heart failure through endothelium-mediated mechanisms in awake dogs 

  35. Science Westphal 285 93 1999 10.1126/science.285.5424.93 Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex 

  36. J. Cell Biol. Yang 142 511 1998 10.1083/jcb.142.2.511 A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart 

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