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[해외논문] PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor) : Defective Regulation in Failing Hearts 원문보기

Cell, v.101 no.4, 2000년, pp.365 - 376  

Marx, Steven O (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Reiken, Steven (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Hisamatsu, Yuji (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Jayaraman, Thotalla (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Burkhoff, Daniel (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Rosemblit, Nora (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) ,  Marks, Andrew R (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA)

Abstract AI-Helper 아이콘AI-Helper

AbstractThe ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is the major source of calcium (Ca2+) required for cardiac muscle excitation-contraction (EC) coupling. The channel is a tetramer comprised of four type 2 RyR polypeptides (RyR2) and four FK506 binding pr...

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