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Cell, v.101 no.4, 2000년, pp.365 - 376
Marx, Steven O (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) , Reiken, Steven (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) , Hisamatsu, Yuji (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) , Jayaraman, Thotalla (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) , Burkhoff, Daniel (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) , Rosemblit, Nora (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA) , Marks, Andrew R (Center for Molecular Cardiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA)
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AbstractThe ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is the major source of calcium (Ca2+) required for cardiac muscle excitation-contraction (EC) coupling. The channel is a tetramer comprised of four type 2 RyR polypeptides (RyR2) and four FK506 binding pr...
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