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[해외논문] FOG-2, a Cofactor for GATA Transcription Factors, Is Essential for Heart Morphogenesis and Development of Coronary Vessels from Epicardium 원문보기

Cell, v.101 no.7, 2000년, pp.729 - 739  

Tevosian, Sergei G (Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School and, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA) ,  Deconinck, Anne E (Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School and, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA) ,  Tanaka, Makoto (Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA) ,  Schinke, Martina (Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School and, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA) ,  Litovsky, Silvio H (Departments of Pediatrics and Pathology, Children's Hospital and Dana Farber Cancer Institute, Beth Israel Deaconess Medical Center, Harvard Medical School and, Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA) ,  Izumo, Seigo (Division of Cardiology, Department of Medicine, Beth Israel Deaconess Med) ,  Fujiwara, Yuko ,  Orkin, Stuart H

Abstract AI-Helper 아이콘AI-Helper

AbstractWe disrupted the FOG-2 gene in mice to define its requirement in vivo. FOG-2−/− embryos die at midgestation with a cardiac defect characterized by a thin ventricular myocardium, common atrioventricular canal, and the tetralogy of Fallot malformation. Remarkably, coronary vascul...

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