[논문]Frequency of neuroleptic malignant syndrome in a large psychiatric hospital in Moscow

Spivak, B; Maline, D.I; Kozyrev, V.N; Mester, R; Neduva, S.A; Ravilov, R.S; Weizman, A

doi:10.1016/S0924-9338(00)00402-8

[해외논문] Frequency of neuroleptic malignant syndrome in a large psychiatric hospital in Moscow

European psychiatry : the journal of the Association of European Psychiatrists, v.15 no.5, 2000년, pp.330 - 333

Spivak, B (Research Unit, Ness Ziona Mental Health Center, POB 1, Ness Ziona 74100, Israel) , Maline, D.I (Moscow Research Institute of Psychiatry, Department of Intensive Therapy, Moscow Psychiatric Hospital No.4, Moscow, Russia) , Kozyrev, V.N (Moscow Psychiatric Hospital No.1, Moscow, Russia) , Mester, R (Research Unit, Ness Ziona Mental Health Center, POB 1, Ness Ziona 74100, Israel) , Neduva, S.A (Moscow Research Institute of Psychiatry, Department of Intensive Therapy, Moscow Psychiatric Hospital No.4, Moscow, Russia) , Ravilov, R.S (Moscow Psychiatric Hospital No.1, Moscow, Russia) , Weizman, A (Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel)

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AbstractA ten-year prospective survey of neuroleptic malignant syndrome (NMS) was performed in a major psychiatric hospital (1,510 beds) in Moscow. All inpatients who developed a persistent and severe extrapyramidal rigidity accompanied by fever after exposure to neuroleptic medication were screened for NMS. The diagnosis of NMS was established according to Levenson’s criteria and at a later stage all NMS cases were reevaluated using the DSM-IV research criteria. Data on age, gender and psychiatric diagnoses were analyzed. Of the 78,708 inpatients treated with neuroleptic agents, 19 separate patients had an episode of NMS, for a frequency of 0.02%. Mortality rate was 10.5% (2/19 patients). Of the three potential risk factors studied, only young age (≤ 25 years) was significantly associated with an increased frequency of NMS (P < 0.01). The low rate of NMS found here compared to studies in other countries may be due to the stringent demands for NMS diagnosis. More large-scale prospective studies including detailed clinical and laboratory data are needed to clarify these differences and their impact on the prevalence and risk factors of NMS.

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참고문헌 (14)

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DOI : 10.1016/S0924-9338(00)00402-8
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