다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
Immunity, v.12 no.3, 2000년, pp.313 - 322
Hernández-Hoyos, Gabriela (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Sohn, Sue J (Department of Immunology, University of Washington, Seattle, Washington 98195, USA) , Rothenberg, Ellen V (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Alberola-Ila, José (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA)
AI-Helper
AbstractThymocytes carrying MHC class I–restricted TCRs differentiate into CD8 T cells, while those recognizing MHC class II become CD4 T cells. The mechanisms underlying how MHC class recognition, coreceptor expression, and effector function are coordinated are not well understood. Since the...
J. Exp. Med. Abraham 173 1421 1991 10.1084/jem.173.6.1421 Delayed thymocyte development induced by augmented expression of p56lck
J. Exp. Med. Alberola-Ila 184 9 1996 10.1084/jem.184.1.9 Positive and negative selection invoke distinct signaling pathways
J. Exp. Med. Basson 187 1249 1998 10.1084/jem.187.8.1249 CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity
Eur. J. Immunol. Bommhardt 27 1152 1997 10.1002/eji.1830270516 Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus
J. Immunol. Bommhardt 163 715 1999 10.4049/jimmunol.163.2.715 Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus
Cell Borgulya 69 529 1992 10.1016/0092-8674(92)90453-J Exclusion and inclusion of α and β T cell receptor alleles
Science Chan 261 1581 1993 10.1126/science.8372352 Thymic selection of cytotoxic T cells independent of CD8α-Lck association
Cell Chan 73 225 1993 10.1016/0092-8674(93)90225-F Another view of the selective model of thymocyte selection
EMBO J. Chan 13 4482 1994 10.1002/j.1460-2075.1994.tb06770.x Role of coreceptors in positive selection and lineage commitment
Immunity Corbella 1 269 1994 10.1016/1074-7613(94)90078-7 Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity
Cell Davis 73 237 1993 10.1016/0092-8674(93)90226-G Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes
J. Biol. Chem. Denny 274 5146 1999 10.1074/jbc.274.8.5146 The Lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling
Immunity Fehling 6 703 1997 10.1016/S1074-7613(00)80446-X Restoration of thymopoiesis in pTα−/− mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or tailless pTα
Curr. Opin. Immunol. Fowlkes 7 188 1995 10.1016/0952-7915(95)80003-4 Positive selection of T cells
J. Immunol. Methods Goldberg 224 1 1999 10.1016/S0022-1759(98)00038-6 A novel method for measuring CTL and NK cell-mediated cytotoxicity using annexin V and two-color flow cytometry
Immunity Goldrath 6 633 1997 10.1016/S1074-7613(00)80351-9 CD8 lineage commitment in the absence of CD8
Proc. Natl. Acad. Sci. USA Hardardottir 92 354 1995 10.1073/pnas.92.2.354 T cells with two functional antigen-specific receptors
J. Immunol. Hare 160 3666 1998 10.4049/jimmunol.160.8.3666 Identification of a developmentally regulated phase of postselection expansion driven by thymic epithelium
J. Exp. Med. Hashimoto 184 931 1996 10.1084/jem.184.3.931 Requirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selection
J. Exp. Med. Heath 178 1807 1993 10.1084/jem.178.5.1807 Expression of two α chains on the surface of T cells in T cell receptor transgenic mice
Cell Hogquist 76 17 1994 10.1016/0092-8674(94)90169-4 T cell receptor antagonist peptides induce positive selection
J. Exp. Med. Itano 183 731 1996 10.1084/jem.183.3.731 The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
Science Iwashima 263 1136 1994 10.1126/science.7509083 Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
J. Biol. Chem. Kamakura 274 26563 1999 10.1074/jbc.274.37.26563 Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
Nature Kaye 341 746 1989 10.1038/341746a0 Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
Nature Killeen 364 729 1993 10.1038/364729a0 Helper T-cell development in the absence of CD4-p56lck association
J. Immunol. Klinken 140 1123 1988 10.4049/jimmunol.140.4.1123 Evolution of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome, MAIDS
EMBO J. Levin 12 1671 1993 10.1002/j.1460-2075.1993.tb05812.x A dominant-negative transgene defines a role for p56lck in thymopoiesis
J. Exp. Med. Lundberg 181 1643 1995 10.1084/jem.181.5.1643 Intermediate steps in positive selection
Mol. Cell. Biol. Luo 10 5305 1990 10.1128/MCB.10.10.5305 Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site
Immunity Matechak 4 337 1996 10.1016/S1074-7613(00)80247-2 MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent
Nature Molina 357 161 1992 10.1038/357161a0 Profound block in thymocytes development in mice lacking p56lck
Immunity Mombaerts 1 261 1994 10.1016/1074-7613(94)90077-9 An activated lck transgene promotes thymocyte development in RAG-1 mutant mice
Annu. Rev. Immunol. Perlmutter 11 451 1993 10.1146/annurev.iy.11.040193.002315 Regulation of lymphocyte function by protein phosphorylation
J. Immunol. Ramsdell 147 1779 1991 10.4049/jimmunol.147.6.1779 The majority of CD4+8− thymocytes are functionally immature
Annu. Rev. Immunol. Robey 12 675 1994 10.1146/annurev.iy.12.040194.003331 Selective events in T cell development
Cell Robey 64 99 1991 10.1016/0092-8674(91)90212-H Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
J. Exp. Med. Robey 179 1997 1994 10.1084/jem.179.6.1997 Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice
J. Immunol. Roy 151 2497 1993 10.4049/jimmunol.151.5.2497 The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells
Nature Seong 356 718 1992 10.1038/356718a0 Signal for T-cell differentiation to a CD4 cell lineages is delivered by CD4 transmembrane region and/or cytoplasmic tail
J. Immunol. Sharp 163 6598 1999 10.4049/jimmunol.163.12.6598 Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling
Immunity Sharp 7 609 1997 10.1016/S1074-7613(00)80382-9 The influence of the MAPK pathway on T cell lineage commitment
Cell Shaw 59 627 1989 10.1016/0092-8674(89)90008-1 The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
J. Exp. Med. Spriggs 176 1543 1992 10.1084/jem.176.6.1543 Recombinant human CD40 ligand stimulates B cell proliferation and Immunoglobulin E secretion
Cell Straus 70 585 1992 10.1016/0092-8674(92)90428-F Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
Immunity Suzuki 2 413 1995 10.1016/1074-7613(95)90149-3 Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages
Eur. J. Immunol. Suzuki 28 3252 1998 10.1002/(SICI)1521-4141(199810)28:10<3252::AID-IMMU3252>3.0.CO;2-G Positive selection of CD4+ T cells by TCR-specific antibodies requires low valency TCR cross-linking
Cell Turner 60 755 1990 10.1016/0092-8674(90)90090-2 Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
Science van Meerwijk 261 911 1993 10.1126/science.8102208 Development of mature CD8+ thymocytes
J. Exp. Med. van Oers 183 1053 1996 10.1084/jem.183.3.1053 Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
J. Immunol. Vandekerckhove 152 1738 1994 10.4049/jimmunol.152.4.1738 In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells
J. Exp. Med. Veillette 170 1671 1989 10.1084/jem.170.5.1671 Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
Cell Veillete 55 301 1988 10.1016/0092-8674(88)90053-0 The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
J. Exp. Med. von Boehmer 183 713 1996 10.1084/jem.183.3.713 CD4/CD8 lineage commitment
Int. Immunol. Wang 10 1623 1998 10.1093/intimm/10.11.1623 Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T lineage commitment
J. Exp. Med. Weist 178 1701 1993 10.1084/jem.178.5.1701 Regulation of T cell receptor expression in immature CD4+ CD8+ thymocytes by p56lck tyrosine kinase
J. Immunol. Wildin 155 1286 1995 10.4049/jimmunol.155.3.1286 Functional dissection of the murine lck distal promoter
해당 논문의 주제분야에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.
*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.
출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.