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Immunity, v.12 no.3, 2000년, pp.313 - 322
Hernández-Hoyos, Gabriela (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Sohn, Sue J (Department of Immunology, University of Washington, Seattle, Washington 98195, USA) , Rothenberg, Ellen V (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA) , Alberola-Ila, José (Division of Biology, California Institute of Technology, Pasadena, California 91125, USA)
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AbstractThymocytes carrying MHC class I–restricted TCRs differentiate into CD8 T cells, while those recognizing MHC class II become CD4 T cells. The mechanisms underlying how MHC class recognition, coreceptor expression, and effector function are coordinated are not well understood. Since the...
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