[논문]Pre-core mutant infections in the Canadian Inuit

Minuk, Gerald Y; Orr, Pamela S; Brown, Rosemay; Macdonald, Sharon; Chaudhary, Rabinda K; Temple, Paula

doi:10.1016/S0168-8278(00)80310-4

[해외논문] Pre-core mutant infections in the Canadian Inuit

Journal of hepatology : the journal of the European Association for the Study of the Liver, v.33 no.5, 2000년, pp.781 - 784

Minuk, Gerald Y (G Y Minuk, Liver Diseases Unit, GF407, Health Sciences Centre, 820 Sherbrook Street, Winnipeg, Manitoba, R3A 1R9, Canada Tel 204 787 4662 Fax 204 775 4255) , Orr, Pamela S (Liver Diseases Unit, University of Manitoba, Winnipeg Manitoba Canada) , Brown, Rosemay (Keewatin Regional Health Board Canada) , Macdonald, Sharon (Northern Medical Unit, University of Manitoba, Winnipeg Manitoba Canada) , Chaudhary, Rabinda K (Laboratory Centre for Disease Control, Ottawa, Ontario, Canada) , Temple, Paula (Liver Diseases Unit, University of Manitoba, Winnipeg Manitoba Canada)

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AbstractBackground/Aims: Previous cross-sectional data suggested that chronic hepatitis B viral (HBV) infections in the Canadian Inuit were inactive. The aim of this study was to confirm these findings and document the prevalence of the subsequently described “pre-core mutant” variant of HBV in this population.Methods: We obtained sera from residents of five remote Canadian Inuit communities. Residents were selected if they were known to be hepatitis B surface antigen (HBsAg) positive or had a history of liver disease. HBV serology, HBV-DNA, and pre-core mutant testing were performed by commercially available assays, polymerase chain reaction (PCR) and direct sequencing of the viral genome, respectively.Results: Sera were obtained from 176/266 (66%) of selected individuals. Thirty-eight (22%) were HBsAg positive and 16 (9.1%) anti-HBs positive. Of HBsAg positive carriers 25/38 (66%) were male as compared to 68/138 (49%) of the remaining individuals (p<0.05). Of 37 HBsAg positive carriers, none were HBeAg positive, 36 (97%) anti-HBe positive and one (3%) HBeAg and anti-HBe negative. Liver enzyme and function tests were normal in all cases. 30/37 (81%) HBsAg positive carriers were HBV-DNA positive and 26/30 (87%) were pre-core mutant positive.Conclusion: The majority of HBV infections in community-based Canadian Inuit are inactive and the prevalence of pre-core mutant infections is the highest reported to date.

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DOI : 10.1016/S0168-8278(00)80310-4
European Association for the Study of the Liver : 저널
Elsevier : 저널 > 논문

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