[논문]Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease

Engelen, Marië; lle PKJ; Wouters, Emiel FM; Deutz, Nicolaas EP; Menheere, Paul PCA; Schols, Annemie MWJ

doi:10.1093/ajcn/72.6.1480

[해외논문] Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease 원문보기

The American journal of clinical nutrition, v.72 no.6, 2000년, pp.1480 - 1487

Engelen, Mariëlle PKJ , Wouters, Emiel FM , Deutz, Nicolaas EP , Menheere, Paul PCA , Schols, Annemie MWJ

Abstract ▼ AI-Helper

BACKGROUND: There is increasing evidence of abnormal protein metabolism in patients with chronic obstructive pulmonary disease (COPD), as reflected by lower plasma branched-chain amino acid (BCAA) concentrations and different muscle amino acid (AA) patterns than in age-matched control subjects. OBJECTIVE: We examined whether the low plasma BCAA concentrations in COPD reflect an imbalance between anabolic and catabolic processes as evidenced by a low fat-free mass (FFM) and alterations in the anabolic hormone insulin and whether discrepancies in muscle AA concentrations between studies are related to different patient characteristics. DESIGN: AA profiles in arterial plasma and quadriceps femoris muscle and insulin concentrations in venous plasma were analyzed in 28 postabsorptive COPD patients (14 with and 14 without macroscopic emphysema) and in 28 control subjects. FFM was measured by dual-energy X-ray absorptiometry. RESULTS: The lower sum of plasma BCAAs in the COPD group than in the control subjects was the result of a lower leucine concentration (P: < 0.001); no significant difference in valine and isoleucine was found between the groups. In the COPD group, the lower leucine concentrations were associated with low FFM (P: < 0.01). Compared with the control group, the muscle-to-plasma leucine gradient was higher in the COPD group (P: < 0.001) and was associated with a higher insulin concentration (P: < 0.01). Several muscle AA concentrations were higher or tended to be higher in the group without emphysema than in the control group, whereas nearly all AA concentrations were lower in the group with emphysema. CONCLUSIONS: Leucine metabolism is altered in COPD patients and is associated with low FFM and high insulin concentrations. There were striking differences in the skeletal muscle AA profile between the COPD subtypes.

참고문헌 (45)

Clin Nutr Engelen 18 275 1999 10.1016/S0261-5614(98)80024-1 Different patterns of chronic tissue wasting among patients with chronic obstructive pulmonary disease

상세보기
Am J Clin Nutr Engelen 71 733 2000 10.1093/ajcn/71.3.733 Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease

상세보기
Am Rev Respir Dis Hunter 124 376 1981 The nutritional status of patients with chronic obstructive pulmonary disease

상세보기
Am Rev Respir Dis Schols 143 1248 1991 10.1164/ajrccm/143.6.1248 Energy balance in patients with chronic obstructive pulmonary disease

상세보기
Clin Sci Green 83 109 1992 10.1042/cs0830109 Comparisons between basal metabolic rate and diet-induced thermogenesis in different types of chronic obstructive pulmonary disease

상세보기
Am Rev Respir Crit Care Med Pouw 158 797 1998 10.1164/ajrccm.158.3.9708097 Plasma and muscle amino-acid levels in relation to resting energy expenditure and inflammation in stable COPD

상세보기
Am J Respir Crit Care Med Engelen 161 98 2000 10.1164/ajrccm.161.1.9901031 Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema

상세보기
Clin Sci Morrison 75 415 1988 10.1042/cs0750415 Muscle wasting in emphysema

상세보기
Monaldi Arch Chest Dis Schols 48 546 1993 Plasma amino acid levels in patients with chronic obstructive pulmonary disease
Am Rev Respir Dis Hofford 141 902 1990 10.1164/ajrccm/141.4_Pt_1.902 The nutritional status in advanced emphysema associated with chronic bronchitis. A study of amino acid and catecholamine levels

상세보기
J Am Coll Cardiol Swan 30 527 1997 10.1016/S0735-1097(97)00185-X Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure

상세보기
Lancet Munro 1 722 1975 10.1016/S0140-6736(75)91632-3 Insulin, plasma amino acid imbalance, and hepatic coma

상세보기
Clin Physiol Jakobsson 15 547 1995 10.1111/j.1475-097X.1995.tb00543.x Insulin resistance is not exhibited by advanced chronic obstructive pulmonary disease patients

상세보기
Am Rev Respir Dis 85 762 1962 Chronic bronchitis, asthma, and pulmonary emphysema by the committee on diagnostic standards for nontuberculosis respiratory disease
J Comput Assist Tomogr Sakai 11 963 1987 10.1097/00004728-198711000-00007 Pulmonary function abnormalities in patients with CT-determined emphysema

상세보기
Thorax Morgan 47 1001 1992 10.1136/thx.47.12.1001 Detection and quantification of pulmonary emphysema by computed tomography: a window of opportunity

상세보기
Lamers 93 1998 Emphysema and airflow limitation in patients with advanced chronic obstructive pulmonary disease: a CT study. Quantitative CT of the lungs: technical aspects and clinical studies. PhD thesis.
Scand J Clin Lab Invest Bergstrom 68 7 1962 Muscle electrolytes in man. Determination by neutron activation analysis on needle biopsy specimens. A study on normal subjects, kidney patients, and patients with chronic diarrhea
Clin Chem Van Eijk 34 2510 1988 10.1093/clinchem/34.12.2510 Fully automated liquid-chromatographic determination of amino acids

상세보기
J Chromatogr van Eijk 620 143 1993 10.1016/0378-4347(93)80062-9 Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2-3 μm Spherisorb ODS II column

상세보기
Am J Clin Nutr Engelen 68 1298 1998 10.1093/ajcn/68.6.1298 Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease

상세보기
JPEN J Parenter Enteral Nutr Schols 16 364 1992 10.1177/0148607192016004364 Measurement of resting energy expenditure in patients with chronic obstructive pulmonary disease in a clinical setting

상세보기
J Physiol Weir 109 1 1949 10.1113/jphysiol.1949.sp004363 New methods for calculating metabolic rate with special reference to protein metabolism

상세보기
Eur J Clin Nutr Creutzberg 52 396 1998 10.1038/sj.ejcn.1600571 Prevalence of an elevated resting energy expenditure in patients with chronic obstructive pulmonary disease in relation to body composition and lung function

상세보기
1986 Voorlichtingsbureau voor de voeding. (Dutch food composition tables.)
Eur Respir J Quanjer 6 5 1993 10.1183/09041950.005s1693 Standardized lung function testing

상세보기
Thorax Schols 51 819 1996 10.1136/thx.51.8.819 Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease

상세보기
Hepatology Andus 13 364 1991 10.1002/hep.1840130226 Effects of cytokines on the liver

상세보기
J Clin Invest Nawabi 85 256 1990 10.1172/JCI114421 Administration of endotoxin, tumor necrosis factor, or interleukin 1 to rats activates skeletal muscle branched-chain alpha-keto acid dehydrogenase

상세보기
JPEN J Parenter Enteral Nutr Halmi 11 458 1987 10.1177/0148607187011005458 Plasma and erythrocyte amino acid concentrations in anorexia nervosa

상세보기
Lancet Saunders 2 795 1967 10.1016/S0140-6736(67)92233-7 Plasma free amino acid pattern in protein-calorie malnutrition. Reappraisal of its diagnostic value

상세보기
Clin Sci Milewski 62 83 1982 10.1042/cs0620083 Intracellular free amino acids in undernourished patients with or without sepsis

상세보기
Ann Surg Vinnars 182 665 1975 10.1097/00000658-197512000-00001 Influence of the postoperative state on the intracellular free amino acids in human muscle tissue

상세보기
Ann Surg Askanazi 191 465 1980 10.1097/00000658-198004000-00013 Muscle and plasma amino acids after injury: hypocaloric glucose vs. amino acid infusion

상세보기
Clin Physiol Essen 12 163 1992 10.1111/j.1475-097X.1992.tb00303.x Free amino acids in plasma and muscle during 24 hours post-operatively-a descriptive study

상세보기
JPEN J Parenter Enteral Nutr Roth 6 240 1982 10.1177/0148607182006003240 Free amino acids in plasma and muscle in fulminant hepatic coma during an extracorporeal liver perfusion

상세보기
Clin Chem Roth 31 1305 1985 10.1093/clinchem/31.8.1305 Amino acid concentrations in plasma and skeletal muscle of patients with acute hemorrhagic necrotizing pancreatitis

상세보기
Clin Nutr Wernerman 4 217 1985 10.1016/0261-5614(85)90005-6 The effect of stress hormones on the interorgan flux of amino acids and on the concentration of free amino acids in skeletal muscle

상세보기
Surg Gynecol Obstet Legaspi 166 233 1988 The effect of starvation and total parenteral nutrition on skeletal muscle amino acid content and membrane potential difference in normal man

상세보기
Ann Surg Askanazi 188 797 1978 10.1097/00000658-197812000-00014 Muscle and plasma amino acids after injury: the role of inactivity

상세보기
Clin Nutr Sandstedt 4 13 1985 10.1016/0261-5614(85)90032-9 Changes in muscle and plasma amino acid metabolism in severe malnutrition. The influence of total parenteral nutrition

상세보기
Diabetes Borghi 34 812 1985 10.2337/diab.34.8.812 Plasma and skeletal muscle free amino acids in type I, insulin-treated diabetic subjects

상세보기
Hepatology Montanari 8 1034 1988 10.1002/hep.1840080509 Free amino acids in plasma and skeletal muscle of patients with liver cirrhosis

상세보기
Kidney Int Bergstrom 38 108 1990 10.1038/ki.1990.174 Plasma and muscle free amino acids in maintenance hemodialysis patients without protein malnutrition

상세보기
Thorax Baarends 52 981 1997 10.1136/thx.52.11.981 Decreased mechanical efficiency in clinically stable patients with chronic obstructive pulmonary disease

상세보기

원문 보기

AccessON 원문보기

원문 URL 링크

DOI : 10.1093/ajcn/72.6.1480 [무료]
American Society for Nutrition : 저널
AccessON : 저널

*원문 PDF 파일 및 링크정보가 존재하지 않을 경우 KISTI DDS 시스템에서 제공하는 원문복사서비스를 사용할 수 있습니다.

오픈액세스(OA) 유형

BRONZE

출판사/학술단체 등이 한시적으로 특별한 프로모션 또는 일정기간 경과 후 접근을 허용하여, 출판사/학술단체 등의 사이트에서 이용 가능한 논문

저작권 관리 안내

내보내기 메뉴

내보내기 구분

파일저장
인쇄
메일전송

구성항목

기본정보
상세정보

관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관

저장형식

Text(ASCII format)
Excel format
RefWorks Direct Export
RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley

메일정보

받는사람 (필수): @
보내는사람 (선택): @
제목
내용: KISTI 검색결과 이메일 서비스

안내

총 건의 자료가 검색되었습니다.

다운받으실 자료의 인덱스를 입력하세요. (1-10,000)

검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다.

데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요)

다운로드 파일은 UTF-8 형태로 저장됩니다.
파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오.

Text(ASCII format)
Excel format

표제어: PCR

동의어: Packet Collision Rate

용어 설명 출처 목록 (6)

용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

AI-Helper ※ AI-Helper는 을 사용합니다.

AI-Helper

안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

연합인증

[해외논문] Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease 원문보기

Abstract ▼ AI-Helper

참고문헌 (45)

이 논문을 인용한 문헌

관련 콘텐츠

원문 보기

원문 URL 링크

오픈액세스(OA) 유형

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format