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[해외논문] Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact 원문보기

Proceedings of the National Academy of Sciences of the United States of America, v.97 no.25, 2000년, pp.13760 - 13765  

Fukui, Yoshinori (Department of Genetics, CREST (Core Research for Evolutional Science and Technology), Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan) ,  Oono, Takamasa (Laboratoire de Biologie Molé) ,  Cabaniols, Jean-Pierre (culaire du Gè) ,  Nakao, Kazuki (ne, Institut Pasteur, 75724 Paris, France) ,  Hirokawa, Katsuiku (Department of DNA Biology and Embryo Engineering, Institute of Medical Science, Tokyo University, Tokyo 108, Japan) ,  Inayoshi, Ayumi (and Department of Pathology and Immunology, Tokyo Medical and Dental University, Tokyo 113, Japan) ,  Sanui, Terukazu (Department of Genetics, CREST (Core Research for Evolutional Science and Technology), Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan) ,  Kanellopoulos, Jean (Laboratoire de Biologie Molé) ,  Iwata, Eiko (culaire du Gè) ,  Noda, Mayuko (ne, Institut Pasteur, 75724 Paris, France) ,  Katsuki, Motoya (Department of DNA Biology and Embryo Engineering, Institute of Medical Science, Tokyo University, Tokyo 108, Japan) ,  Kourilsky, Philippe (and Department of Pathology and Immunology, Tokyo Medical and Dental University, Tokyo 113, Japan) ,  Sasazuki, Takehiko (Department of Genetics, CREST (Core Rese)

Abstract AI-Helper 아이콘AI-Helper

T cell differentiation in the thymus is driven by positive selection through the interaction of αβ T cell receptors (TCRs) with self-peptides bound to self-major histocompatibility complex molecules, yet the influence of the peptide sequence on this process remains unknown. To address thi...

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