[해외논문]Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat원문보기
The effects of the long lasting and potent PAF receptor antagonist UK74505 were assessed on the local and remote injuries following ischaemia and reperfusion (I/R) of the superior mesenteric artery (SMA) in rats.In a severe model of ischaemia (120 min) and reperfusion (120) injury, in addition to th...
The effects of the long lasting and potent PAF receptor antagonist UK74505 were assessed on the local and remote injuries following ischaemia and reperfusion (I/R) of the superior mesenteric artery (SMA) in rats.In a severe model of ischaemia (120 min) and reperfusion (120) injury, in addition to the local and remote increases in vascular permeability and neutrophil accumulation, there was significant tissue haemorrhage, blood neutropenia, systemic hypotension and elevated local and systemic TNF‐α levels.Post‐ischaemic treatment with the selectin blocker fucoidin (10 mg kg−1) prevented neutrophil accumulation in tissue and, in consequence, all the local and systemic injuries following severe I/R.Treatment with an optimal dose of UK74505 (1 mg kg−1) also reversed local and remote neutrophil accumulation, increases in vascular permeability and intestinal haemorrhage. UK74505 partially inhibited blood neutropenia and reperfusion‐induced hypotension.Interestingly, both fucoidin and UK74505 prevented the local, but not systemic, increases of TNF‐α levels following severe I/R injury, demonstrating an important role of migrating cells for the local production of TNF‐α. However, the results do not support a role for PAF as an intermediate molecule in the production of systemic TNF‐α.The beneficial effects of UK74505 and other PAF receptor antagonists in models of I/R injury in animals and the safety of UK74505 use in man warrant further investigations of the use of this drug as preventive measure for I/R injury in humans.British Journal of Pharmacology (2000) 131, 1800-1808; doi:10.1038/sj.bjp.0703756
The effects of the long lasting and potent PAF receptor antagonist UK74505 were assessed on the local and remote injuries following ischaemia and reperfusion (I/R) of the superior mesenteric artery (SMA) in rats.In a severe model of ischaemia (120 min) and reperfusion (120) injury, in addition to the local and remote increases in vascular permeability and neutrophil accumulation, there was significant tissue haemorrhage, blood neutropenia, systemic hypotension and elevated local and systemic TNF‐α levels.Post‐ischaemic treatment with the selectin blocker fucoidin (10 mg kg−1) prevented neutrophil accumulation in tissue and, in consequence, all the local and systemic injuries following severe I/R.Treatment with an optimal dose of UK74505 (1 mg kg−1) also reversed local and remote neutrophil accumulation, increases in vascular permeability and intestinal haemorrhage. UK74505 partially inhibited blood neutropenia and reperfusion‐induced hypotension.Interestingly, both fucoidin and UK74505 prevented the local, but not systemic, increases of TNF‐α levels following severe I/R injury, demonstrating an important role of migrating cells for the local production of TNF‐α. However, the results do not support a role for PAF as an intermediate molecule in the production of systemic TNF‐α.The beneficial effects of UK74505 and other PAF receptor antagonists in models of I/R injury in animals and the safety of UK74505 use in man warrant further investigations of the use of this drug as preventive measure for I/R injury in humans.British Journal of Pharmacology (2000) 131, 1800-1808; doi:10.1038/sj.bjp.0703756
참고문헌 (34)
Agents Actions (Suppl.) ALABASTER V.A. 221 34 1991 UK‐74505, a novel and selective PAF antagonist, exhibits potent and long lasting activity in vivo
J. Immunol. AU B.T. 5411 152 1994 10.4049/jimmunol.152.11.5411 Zymosan‐induced IL‐8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet‐activating factor as an autocrine modulator
Matos, Ione M, Souza, Danielle G, Seabra, Danielle G, Freire-Maia, Lineu, Teixeira, Mauro M.
Effects of tachykinin NK1 or PAF receptor blockade on the lung injury induced by scorpion venom in rats.
European journal of pharmacology,
vol.376,
no.3,
293-300.
Ivey, C L, Williams, F M, Collins, P D, Jose, P J, Williams, T J.
Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit. Evidence for a role for C5a and interleukin-8..
The Journal of clinical investigation,
vol.95,
no.6,
2720-2728.
Jezequel, S. G., Uden, S., Wastall, P..
Modipafant, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man.
Xenobiotica,
vol.26,
no.9,
963-975.
Kim, Fernando J., Moore, Ernest F., Moore, Frederick A., Bifel, Walter L., Fontes, Belchor, Banerjee, Anirban.
Reperfused Gut Elaborates PAF That Chemoattracts and Primes Neutrophils.
The Journal of surgical research,
vol.58,
no.6,
636-640.
Am. J. Physiol. KUBES P. G300 259 1990 Role of platelet‐activating factor in ischaemia/reperfusion‐induced leukocyte adherence
Kubes, P, Jutila, M, Payne, D.
Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion..
The Journal of clinical investigation,
vol.95,
no.6,
2510-2519.
Blood KUBO H. 283 92 1998 10.1182/blood.V92.1.283.413a04_283_290 Complement fragment‐induced release of neutrophils from bone marrow and sequestration within pulmonary capillaries in rabbits
Kuitert, L M, Angus, R M, Barnes, N C, Barnes, P J, Bone, M F, Chung, K F, Fairfax, A J, Higenbotham, T W, O'Connor, B J, Piotrowska, B.
Effect of a novel potent platelet-activating factor antagonist, modipafant, in clinical asthma..
American journal of respiratory and critical care medicine : an official journal of the American Thoracic Society, medical section of the American Lung Association,
vol.151,
no.5,
1331-1335.
Ley, K, Linnemann, G, Meinen, M, Stoolman, LM, Gaehtgens, P.
Fucoidin, but not yeast polyphosphomannan PPME, inhibits leukocyte rolling in venules of the rat mesentery.
Blood,
vol.81,
no.1,
177-185.
Loucks, Eric B., Symersky, Petr, Qayumi, A. Karim.
Platelet-Activating Factor Antagonism: A New Concept in the Management of Regional Myocardial Ischemia-Reperfusion Injury.
Journal of investigative surgery : the official journal of the Academy of Surgical Research,
vol.10,
no.6,
321-338.
Miotla, Jadwiga M., Jeffery, Peter K., Hellewell, Paul G..
Platelet-activating Factor Plays a Pivotal Role in the Induction of Experimental Lung Injury.
American journal of respiratory cell and molecular biology : an official journal of the american thoracic society, medical section of the american lung association,
vol.18,
no.2,
197-204.
J. Lipid Mediat. Cell Signal. PARRY M.J. 251 10 1994 Pharmacological profile of UK‐74,505, a novel and selective PAF antagonist with potent and prolonged oral activity
Prescott, Stephen M., McIntyre, Thomas M., Zimmerman, Guy.
Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury.
The Journal of clinical investigation,
vol.104,
no.8,
1019-1020.
Eur. Cytokine Netw. REES G.S. 383 10 1999 Rat tumour necrosis factor‐alpha: expression in recombinant Pichia pastoris, purification, characterization and development of a novel ELISA
J. Pharmacol. Exp. Ther. RIERA M. 786 280 1997 Neutrophils accentuate renal cold ischaemia‐reperfusion injury. Dose‐dependent protective effect of a platelet‐activating factor receptor antagonist
Ritter, Leslie S, Copeland, Jack G, McDonagh, Paul F.
Fucoidin reduces coronary microvascular leukocyte accumulation early in reperfusion.
The Annals of thoracic surgery,
vol.66,
no.6,
2063-2071.
Souza, Danielle G, Coutinho, Sibele F, Silveira, Micheline R, Cara, Denise C, Teixeira, Mauro M.
Effects of a BLT receptor antagonist on local and remote reperfusion injuries after transient ischemia of the superior mesenteric artery in rats.
European journal of pharmacology,
vol.403,
no.1,
121-128.
Tavares de Lima, Wothan, Steil, Ana A, Russo, Momtchilo, Starobinas, Nancy, Teixeira, Catarina F.P, Jancar, Sonia.
Lipid mediators, tumor necrosis factor and nitric oxide and their interactions in immune-complex-induced lung injury.
European journal of pharmacology,
vol.358,
no.1,
69-75.
Teixeira, Mauro M, Hellewell, Paul G.
The effect of the selectin binding polysaccharide fucoidin on eosinophil recruitment in vivo.
British journal of pharmacology : BJP,
vol.120,
no.6,
1059-1066.
Yamada, Masateru, Tanimoto, Atsuo, Ichinowatari, Gaku, Yaginuma, Hiroshi, Ohuchi, Kazuo.
Possible participation of intracellular platelet-activating factor in tumor necrosis factor-α production by rat peritoneal macrophages.
European journal of pharmacology,
vol.374,
no.3,
341-350.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.