최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기The Journal of experimental medicine, v.192 no.10, 2000년, pp.1479 - 1490
Giannola, Diane M. (Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104) , Shlomchik, Warren D. (Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510) , Jegathesan, Mithila (Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104) , Liebowitz, David (Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104) , Abrams, Charles S. (Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104) , Kadesch, Tom (Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104) , Dancis, Andrew (Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104) , Emerson, Stephen G. (Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104)
The homeobox genes encode a family of transcription factors that regulate development and postnatal tissue homeostasis. Since HOXB4 plays a key role in regulating the balance between hematopoietic stem cell renewal and differentiation, we studied the molecular regulation of HOXB4 expression in human...
Garber R.L. Kuroiwa A. Gehring W.J. Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila EMBO (Eur. Mol. Biol. Organ.) J. 2 1993 2027 2037
Kessel M. Gruss P. Murine developmental control genes Science 249 1990 374 379 1974085
Graham A. Papalopulu N. Krumlauf R. The murine and Drosophila homeobox gene complexes have common features of organization and expression Cell. 57 1989 376 378
Lawrence H.J. Sauvageau G. Humphries R.K. Largman C. The role of HOX homeobox genes in normal and leukemic hematopoiesis Stem Cells. 14 1996 281 291 8724694
Vielle-Grosjean I. Roullot V. Courtois G. Identification of homeobox containing genes expressed in hematopoietic blast cells Biochem. Biophys. Res. Commun. 185 1992 785 792 1351723
Sauvageau G. Lansdorp P.M. Eaves C.E. Hogge D.E. Dragowska W.H. Reid D.S. Largman C. Lawrence H.J. Humphries R.K. Differential expression of homeobox genes in functionally distinct CD34 + subpopulations of human bone marrow cells Proc. Natl. Acad. Sci. USA. 91 1994 12223 12227 7527557
Giampaolo A. Sterpetti P. Bulgarini D. Samoggia P. Pelosi E. Valtieri M. Peschle C. Key functional role and lineage-specific expression of selected HoxB genes in purified hematopoietic progenitor differentiation Blood. 84 1994 3637 3647 7949119
Moretti P. Simmons P. Thomas P. Identification of homeobox genes expressed in human haemopoietic progenitor cells Gene. 144 1994 213 219 7518789
Shen W.F. Detmer K. Mathews C.H. Hack F.M. Morgan D.S. Lawrence H.J. Largman C. Modulation of homeobox gene expression alters the phenotype of human hematopoietic cell lines EMBO (Eur. Mol. Biol. Organ.) J. 11 1992 993 999
Wu J. Zhu J.Q. Zhu D.X. Scharfman A. Lamblin G. Han K.K. Selective inhibition of normal murine myelopoiesis in vitro by a Hox 2.3 antisense oligodeoxynucleotide Cell. Mol. Biol. 38 1992 367 376 1354076
Thorsteinsdottir U. Sauvageau G. Hough M.R. Drogowska W. Lansdorp P.M. Lawrence H.J. Largman C. Humphries R.K. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia Mol. Cell. Biol. 17 1997 495 505 8972230
Sauvageau G. Thorsteinsdottir U. Hough M.R. Hugo P. Lawrence H.J. Largman C. Humphries R.K. Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation Immunity 6 1997 13 22 9052833
Sauvageau G. Thorsteinsdottir U. Eaves C.J. Lawrence H.J. Largman C. Lansdorp P.M. Humphries R.K. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo Genes Dev. 9 1995 1753 1765 7622039
Du H. Roy A.L. Roeder R.G. Human transcription factor USF stimulates transcription of the initiator elements of the HIV-1 and the Ad-ML promoters EMBO (Eur. Mol. Biol. Organ.) J. 12 1993 501 511
Carter R.S. Ordentlich P. Kadesch T. Selective utilization of basic helix-loop-helix-leucine zipper proteins at the immunoglobulin heavy chain enhancer Mol. Cell. Biol. 17 1997 18 23 8972181
Seger R. Seger D. Reszka A.A. Munar E.S. Eldar-Finkelman H. Dobrowolska G. Jensen A.M. Campbell J.S. Fischer E.H. Krebs E.G. Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII J. Biol. Chem. 269 1994 25699 25709 7929275
Ma A.D. Abrams C.S. Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway J. Biol. Chem. 274 1999 28730 28735 10497244
Gottschalk L. Giannola D. Emerson S.G. Molecular regulation of the human IL-3 geneinducible T cell restricted expression requires intact AP-1 and Elf-1 nuclear protein binding sites J. Exp. Med. 178 1993 1681 1692 8228815
Gutman A. Gilthorpe J. Rigby P.W. Multiple positive and negative regulatory elements in the promoter of the mouse homeobox gene Hoxb-4 Mol. Cell. Biol. 14 1994 8143 8154 7969151
Kaushansky K. Thrombopoietin and the hematopoietic stem cell Blood. 92 1999 1 3 9639491
Matsunaga T. Kato T. Miyazaki H. Ogawa M. Thrombopoietin promotes the survival of murine hematopoietic long-term reconstituting cellscomparison with the effects of FLT3/FLK-2 ligand and interleukin-6 Blood. 92 1999 452 461 9657744
Luo Y. Vijaychander S. Stile J. Zhu L. Cloning and analysis of DNA-binding proteins by yeast one-hybrid and one-two-hybrid systems Biotechniques. 20 1996 564 568 8800670
Sawadogo M. Roeder R.G. Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region Cell. 43 1995 165 175 4075392
Carthew R.W. Chodosh L.A. Sharp P.A. An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter Cell. 43 1995 439 448 4075400
Sirito M. Lin Q. Maity T. Sawadogo M. Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells Nucleic Acids Res. 22 1994 427 433 8127680
Gregor P.D. Sawadogo M. Roeder R.G. The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer Genes Dev 4 1990 1730 1740 2249772
Sirito M. Walker S. Lin Q. Kozlowski J.T. Klein W.H.K. Sawadogo M. Members of the USF family of helix-loop-helix proteins bind DNA as homo- as well as heterodimers Gene Expr 2 1992 231 240 1450663
Kennedy H.J. Viollet B. Rafiq I. Kahn A. Rutter G.A. Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet β-cells J. Biol. Chem. 372 1997 20636 20640 9252379
Wang D. Sul H.S. Upstream stimulatory factor binding to the E-box at −65 is required for insulin regulation of the fatty acid synthase promoter J. Biol. Chem. 272 1997 26367 26374 9334210
Breen G.A.M. Jordan E.M. Regulation of the nuclear gene that encodes the α-subunit of the mitochondrial F 0 F 1 -ATP synthase complex J. Biol. Chem. 272 1997 10538 10542 9099698
Hodgkinson C.A. Moore K.J. Nakayama A. Steinbrimsson E. Copeland N.G. Jenkins N.A. Arnheiter H. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein Cell 74 1993 395 404 8343963
Steingrimsson E. Moore K.J. Lamoreux M.L. Ferre-D'Amare A.R. Burley S.K. Zimring D.C. Skow L.C. Hodgkinson C.A. Arnheiter H. Copeland N.G. Jenkins N.A. Molecular basis of mouse microphthalmia ( mi ) mutations helps explain their developmental and phenotypic consequences Nat. Genet. 8 1994 256 262 7874168
Tassabehji M. Newton V.E. Read A.P. Waardenburg syndrome type 2 caused by mutations in the human microphthalmia (MITF) gene Nat. Genet. 8 1994 251 255 7874167
Yasumoto K.-K. Yokoyama K. Shibata K. Tomita Y. Shibahara S. Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene Mol. Cell. Biol. 14 1994 8058 8070 7969144
Yachibana M. Takeda K. Nobukuni Y. Urabe K. Longe J.E. Meyers K.A. Aaronson S.A. Miki T. Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics Nat. Genet. 14 1996 50 54 8782819
Morii E. Jippo T. Tsujimura T. Hashimoto K. Kim D.-K. Lee Y.-M Ohigara H. Tsujino K. Kim H.-M. Kitamura Y. Abnormal expression of mouse mast cell protease 5 gene in cultured mast cells derived from mutant mi / mi mice Blood. 90 1997 3057 3066 9376586
Morii E. Tsujimra T. Jippo T. Hashimoto K. Takebayashi K. Tsujino K. Nomura S. Yamamoto M. Kitamura Y. Regulation of mouse mast cell protease 6 gene expression by transcription factor encoded by the mi locus Blood. 88 1996 2488 2494 8839840
Zhang Z.C. Nechushtan H. Jacob-Hirsch J. Avni D. Meyuhas O. Razin E. Growth-dependent and PKC-mediated translational regulation of the upstream stimulating factor-2 (USF2) mRNA in hematopoietic cells Oncogene 16 1999 763 769 9488040
Tsujimra T. Morii E. Nozaki M. Hashimoto K. Yasuhiro M. Takebayashi K. Kondo T. Kanakura Y. Kitamura Y. Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice Blood. 88 1996 1225 1233 8695840
Hemesath T.J. Price E.R. Takemoto C. Badalian T. Fisher D.E. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes Nature. 391 1998 298 301 9440696
Graham A. Papalopulu N. Lorimer J. McVey J.H. Tuddenham E.G.D. Krumlauf R. Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene Genes Dev 2 1988 1424 1438 2463210
Whiting J. Marshall H. Cook M. Krumlauf R. Rigby P.W.J. Stott D. Allemann R.K. Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression Genes Dev 5 1991 2048 2059 1682218
Gould A. Morrison A. Sproat G. White R.A.H. Krumlauf R. Positive cross-regulation and enhancer sharingtwo mechanisms for specifying overlapping Hox expression patterns Genes Dev. 11 1997 900 913 9106661
Gould A. Itasaki N. Krumlauf R. Initiation of rhombomeric Hoxb4 expression requires induction by somites and a retinoid pathway Neuron 21 1999 39 51 9697850
Simeone A. Acampora D. Nigro V. Faiella A. D'Esposito M. Stornaiuolo A. Mavilio F. Boncinelli E. Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells Mech. Dev 33 1991 215 228 1677812
Faiella A. Zappavigna V. Mavilio F. Boncinelli E. Inhibition of retinoic acid-induced activation of 3′ human HOXB genes by antisense oligonucleotides affects sequential activation of genes located upstream in the four HOX clusters Proc. Natl. Acad. Sci. USA. 91 1994 5335 5339 7911240
Sirito M. Lin Q. Deng J.M. Behringer R.R. Sawadogo M. Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice Proc. Natl. Acad. Sci. USA. 95 1998 3758 3763 9520440
※ AI-Helper는 부적절한 답변을 할 수 있습니다.