[논문]Platelet Activation in the Gyro C1E3 Centrifugal Pump: Comparison with the Terumo Capiox and the Nikkiso HPM-15

Kawahito, Koji; Adachi, Hideo; Ino, Takashi

doi:10.1046/j.1525-1594.2000.06639.x

[해외논문] Platelet Activation in the Gyro C1E3 Centrifugal Pump: Comparison with the Terumo Capiox and the Nikkiso HPM-15

Artificial organs, v.24 no.11, 2000년, pp.889 - 892

Kawahito, Koji , Adachi, Hideo , Ino, Takashi

Abstract ▼ AI-Helper

Abstract: The Gyro C1E3 was developed as a cardiopulmonary bypass pump incorporating the sealless double pivot bearing system. In this study, we evaluated platelet activation induced by the Gyro C1E3 in vitro and in comparison to that of other centrifugal pumps. Rates of increase (RI) for &bgr;-thromboglobulin (&bgr;-TG) and platelet factor 4 (PF4) in the Gyro C1E3 were calculated from in vitro data and compared with the rate of increase in the Capiox (Terumo) and HPM-15 (Nikkiso) pumps. Fresh human blood was used, and a flow of 5.0 L/min with a &Dgr;P (pressure difference between the outlet and inlet of the pump) of 100 mm Hg employed. RI = &Dgr;&bgr;-TG/&Dgr;N and &Dgr;PF4/&Dgr;N were used where &Dgr;&bgr;-TG is the increase in &bgr;-TG, &Dgr;PF4 is the increase in PF4, and &Dgr;N is the increase in the passing number and where N = Qt/V (t = time, V = priming volume, and Q = flow rate). The mean RI for &bgr;-TG was 0.26 ± 0.05 in the Gyro C1E3, 0.20 ± 0.07 in the Capiox, and 0.15 ± 0.02 in the HPM-15. The mean RI for PF4 was 0.15 ± 0.03 in the Gyro C1E3, 0.12 ± 0.05 in the Capiox, and 0.09 ± 0.04 in the HPM-15. While there was no difference in RI for &bgr;-TG and PF4 between the Gyro C1E3 and Capiox, RI for &bgr;-TG and PF4 were significantly higher in the Gyro C1E3 than in the HPM-15 (p = 0.006 and 0.029). In vitro evaluation using RI for &bgr;-TG and PF4 showed platelet damage caused by the Gyro C1E3 and the Capiox to be nearly equal while the HPM-15 was less traumatic to platelets than the Gyro C1E3.

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참고문헌 (11)

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DOI : 10.1046/j.1525-1594.2000.06639.x
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