[논문]Thrombin formation and fibrinolytic activity in patients with acute myocardial infarction or unstable angina: in-hospital course and relationship with recurrent angina at rest

Figueras, J.; Monasterio, Y.; Lidon, R.M.; Nieto, E.; Soler-Soler, J.

doi:10.1016/S0735-1097(00)01023-8

[해외논문] Thrombin formation and fibrinolytic activity in patients with acute myocardial infarction or unstable angina: in-hospital course and relationship with recurrent angina at rest

Journal of the American College of Cardiology, v.36 no.7, 2000년, pp.2036 - 2043

Figueras, J. , Monasterio, Y. , Lidon, R.M. , Nieto, E. , Soler-Soler, J.

Abstract ▼ AI-Helper

OBJECTIVES The goal of this study was to investigate possible differences in thrombin generation or fibrinolytic capacity in patients with unstable angina (UA) or acute myocardial infarction (AMI) with or without recurrent angina at rest. BACKGROUND Angina at rest in patients with AMI or UA is generally produced by a reduction in coronary flow, but it is unclear whether patients with or without this event differ in their thrombin generation or in their fibrinolytic capacities, which might influence the course of the culprit lesion. METHODS Thrombin-antithrombin complex (TAT), D-dimer, fibrinogen and plasminogen activator inhibitor (PAI-1) antigen plasma levels were determined in 40 patients with AMI and in 23 with UA on admission, at 10 days and at three months. RESULTS First day values for TAT, fibrinogen and D-dimer were comparable in patients with AMI and in those with UA. At 10 days they increased significantly in each group, and at 3 months they decreased to a similar extent. First day PAI-1 levels, however, were highest in both groups and declined in AMI patients at 10 days and at three months, whereas they also decreased at 10 days in UA patients but not any further at three months. Ten patients with AMI (25%) and 12 with UA (52%) developed in-hospital angina at rest. First day values for TAT, fibrinogen and D-dimer were similar in patients with or without angina, but PAI-1 levels were higher in the former subset (p < 0.008). At 10 days, however, TAT (p < 0.013) and D-dimer (p < 0.013) were higher in patients who developed angina than in those who did not. CONCLUSIONS The higher inhibition of fibrinolytic activity in the first day in patients with AMI or UA who will develop recurrent angina suggests that maintenance of a prothrombotic status may contribute to its mechanisms, perhaps by preventing passivation of the culprit thrombus/plaque. This is consistent with greater thrombin generation and greater levels of fibrynolitic products at 10 days observed in these patients compared with those who attain early stability.

참고문헌 (51)

Am J Cardiol Allison 204 1978 10.1016/0002-9149(78)90157-1 Coronary anatomy and arteriography in patients with unstable angina pectoris

상세보기
J Am Coll Cardiol Langer 13 1495 1989 10.1016/0735-1097(89)90338-0 ST segment shift in unstable angina

상세보기
Circulation Bosch 75 988 1987 10.1161/01.CIR.75.5.988 Early postinfarction ischemia

상세보기
Eur Heart J Figueras 14 185 1993 10.1093/eurheartj/14.2.185 Coronary reserve, extent of coronary disease, recurrent angina and ECG changes during pain in the in-hospital prognosis of acute coronary syndromes

상세보기
Circulation Figueras 59 955 1979 10.1161/01.CIR.59.5.955 Mechanisms of rest and nocturnal angina

상세보기
Circulation Chierchia 61 759 1980 10.1161/01.CIR.61.4.759 Sequence of events in angina at rest

상세보기
Circulation Ouyyumi 86 22 1992 10.1161/01.CIR.86.1.22 Circadian variation in ischemic threshold. A mechanism underlying the circadian variation in ischemic events

상세보기
Circulation Figueras 92 1734 1995 10.1161/01.CIR.92.7.1737 Early morning reduction in ischemic threshold in patients with unstable angina and significant coronary artery disease

상세보기
Circulation Gotoh 77 526 1988 10.1161/01.CIR.77.3.526 The role of intracoronary thrombus in unstable angina

상세보기
Br J Haematol Hunt 60 715 1985 10.1111/j.1365-2141.1985.tb07476.x Serum cross-linked fibrin (SPD) and fibrinogen/fibrin degradation products (FDP) in disorders associated with activation of the coagulation or fybrinolytic systems

상세보기
Thromb Res Alessi 60 509 1990 10.1016/0049-3848(90)90235-5 Correlations between t-PA and PAI-1 antigen and activity and t-PA/PAI-1 complexes in plasma of control subjects and of patients with increased t-PA or PAI-1 levels

상세보기
Thromb Haemost Pedersen 73 835 1995 10.1055/s-0038-1653877 Plasminogen activator inhibitor type I determines plasmin formation in patients with ischemic heart disease

상세보기
Clin Sci Lip 89 205 1995 10.1042/cs0890205 Fibrin D-dimer

상세보기
Br Heart J Sharma 40 526 1978 10.1136/hrt.40.5.526 Platelet adhesiveness, plasma fibrinogen and fibrinolytic activity in acute myocardial infarction

상세보기
Br Heart J Neumann 62 421 1989 10.1136/hrt.62.6.421 Haemorrheological abnormalities in unstable angina pectoris

상세보기
Circulation Jude 90 1662 1994 10.1161/01.CIR.90.4.1662 Evidence for time-dependent activation of monocytes in the systemic circulation in unstable angina but not in acute myocardial infarction or in stable angina

상세보기
Br Heart J Aznar 59 535 1988 10.1136/hrt.59.5.535 Plasminogen activator inhibitor and the fibrinolytic variables in patients with coronary artery disease

상세보기
J Am Med Assoc Hershberg 219 855 1972 10.1001/jama.1972.03190330027005 Hematocrit and prognosis in patients with acute myocardial infarction

상세보기
Br Med Bull Brozovic 33 231 1977 10.1093/oxfordjournals.bmb.a071441 Physiological mechanisms in coagulation and fibrinolysis

상세보기
Ann NY Acad Sci Kushner 389 39 1982 10.1111/j.1749-6632.1982.tb22124.x The phenomenon of the acute phase response

상세보기
Circulation Hoffmeister 91 2520 1995 10.1161/01.CIR.91.10.2520 Alterations of coagulation and fibrinolytic and kallikrein-kinin systems in the acute and postacute phases in patients with unstable angina pectoris

상세보기
Int J Cardiol Al-Nozha 43 269 1994 10.1016/0167-5273(94)90207-0 Haemostatic variables in patients with unstable angina

상세보기
Circulation Biasucci 94 874 1996 10.1161/01.CIR.94.5.874 Elevated levels of interleukin-6 in unstable angina

상세보기
Circulation Merlini 90 61 1994 10.1161/01.CIR.90.1.61 Persistent activation of coagulation mechanism in unstable angina and myocardial infarction

상세보기
J Am Coll Cardiol Alexopoulos 17 866 1991 10.1016/0735-1097(91)90867-9 Thrombosis-related markers in unstable angina pectoris

상세보기
Am J Cardiol Sakamoto 70 271 1992 10.1016/0002-9149(92)90603-V Association of patency of the infarct-related coronary artery with plasma levels of plasminogen activator inhibitor activity in acute myocardial infarction

상세보기
Circulation Francis 75 1170 1987 10.1161/01.CIR.75.6.1170 Increased plasma concentration of cross-linked fibrin polymers in acute myocardial infarction

상세보기
N Engl J Med Kruskal 317 1361 1987 10.1056/NEJM198711263172201 Fibrin and fibrinogen-related antigens in patients with stable and unstable coronary artery disease

상세보기
J Am Coll Cardiol Eisenberg 18 898 1991 10.1016/0735-1097(91)90744-T Relation between ST segment shifts during ischemia and thrombin activity in patients with unstable angina pectoris

상세보기
Thromb Res Eisenberg 46 109 1987 10.1016/0049-3848(87)90211-8 Relationship between elevated plasma levels of crosslinked fibrin degradation products (XL-FDP) and the clinical presentation of patients with myocardial infarction

상세보기
Stroke Takano 23 194 1992 10.1161/01.STR.23.2.194 Markers of hypercoagulable state following acute ischemic stroke

상세보기
Am J Cardiol Berck 65 168 1990 10.1016/0002-9149(90)90079-G Elevation of C-reactive protein in “active” coronary artery disease

상세보기
N Engl J Med Liuzzo 331 417 1994 10.1056/NEJM199408183310701 The prognostic value of C-reactive protein and serum amyloyd A protein in severe unstable angina

상세보기
Circulation Montalescot 98 294 1998 10.1161/01.CIR.98.4.294 Early increase of von Willebrand factor predicts adverse outcome in unstable coronary artery disease

상세보기
Thromb Haemost Margulis 55 366 1986 10.1055/s-0038-1661565 The von Willebrand factor in myocardial infarction and unstable angina

상세보기
Am J Cardiol Andreotti 62 635 1988 10.1016/0002-9149(88)90669-8 Major circadian fluctuations in fibrinolytic factors and possible relevance to time of onset of myocardial infarction, sudden death and stroke

상세보기
Circulation Biassucci 93 2121 1996 10.1161/01.CIR.93.12.2121 Temporal relation between ischemic episodes and activation of the coagulation system in unstable angina

상세보기
Thromb Haemost Pelzer 59 101 1988 10.1055/s-0038-1646768 Determination of human thrombin-antithrombin III complex in plasma with an enzyme-linked immunosorbent assay

상세보기
Thromb Res Nieuwenhuizen 48 59 1975 Catabolism of purified rat fibrin (ogen) plasmin degradation products in rats
Circulation Van der Wal 89 36 1994 10.1161/01.CIR.89.1.36 Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology

상세보기
Circulation Moreno 90 775 1994 10.1161/01.CIR.90.2.775 Macrophage infiltration in acute coronary syndromes

상세보기
J Am Coll Cardiol Wilensky 21 692 1993 10.1016/0735-1097(93)90102-7 Intracoronary artery thrombus formation in unstable angina

상세보기
Circulation Ardissino 93 1634 1996 10.1161/01.CIR.93.9.1634 Thrombin activity and early outcome in unstable angina pectoris

상세보기
Int J Cardiol Figueras 4 261 1983 10.1016/0167-5273(83)90082-7 Prognostic implications of early postinfarction angina after acute transmural myocardial infarction

상세보기
Am Heart J Suefuji 134 253 1997 10.1016/S0002-8703(97)70132-7 Increased plasma tissue factor levels in acute myocardial infarction

상세보기
Circulation Mombelli 69 684 1984 10.1161/01.CIR.69.4.684 Effect of heparin on plasma fibrinopeptide A in patients with acute myocardial infarction

상세보기
Circulation Granger 91 1929 1995 10.1161/01.CIR.91.7.1929 Rebound increase in thrombin generation and activity after cessation of intravenous heparin in patients with acute coronary syndromes

상세보기
Am J Cardiol Ring 67 1330 1991 10.1016/0002-9149(91)90460-3 Detection of intracoronary fibrin degradation after coronary balloon angioplasty

상세보기
Circulation Liuzzo 98 2370 1998 10.1161/01.CIR.98.22.2370 Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina

상세보기
Circulation Ouyang 70 367 1984 10.1161/01.CIR.70.3.367 Variables predictive of successful medical therapy in patients with unstable angina

상세보기
Am J Cardiol Wilcox 65 1313 1990 10.1016/0002-9149(90)91319-2 Clinical significance of silent ischemia in unstable angina pectoris

상세보기

표제어: PCR

동의어: Packet Collision Rate

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용어 설명: PCR은 세균 특이성이 있는 primer를 이용하여 적은 수의 세균이 있을지라도 쉽게 검출할 수 있는 유용한 방법이며, 이를 이용하여 구강 내 치면세균막이나 타액에서 직접 세균을 검출할 수 있게 되었다[8].

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[해외논문] Thrombin formation and fibrinolytic activity in patients with acute myocardial infarction or unstable angina: in-hospital course and relationship with recurrent angina at rest

Abstract ▼ AI-Helper

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