[논문]The use of 6‐mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy

Boulton‐; Jones, J. R.; Pritchard, K.; Mahmoud, A. A.

doi:10.1046/j.1365-2036.2000.00872.x

[해외논문] The use of 6‐mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy

Alimentary pharmacology & therapeutics, v.14 no.12, 2000년, pp.1561 - 1565

Boulton‐Jones, J. R. , Pritchard, K. , Mahmoud, A. A.

Abstract ▼ AI-Helper

Introduction:Azathioprine is a useful therapy in patients with inflammatory bowel disease that is difficult to control. However, 10% of patients are unable to tolerate azathioprine, and the best form of treatment for this group of patients is unknown. The azathioprine metabolite 6‐mercaptopurine may be a useful therapy for these patients.Aim:To review our clinical experience of the use of the 6‐mercaptopurine in inflammatory bowel disease patients who are intolerant of azathioprine.Methods:All patients who were prescribed 6‐mercaptopurine in a 2‐year period were identified from pharmacy records. The case notes were reviewed and those who had previously been intolerant of azathioprine were included.Results:A total of 19 with either ulcerative colitis and Crohn’s disease were included. The reasons for discontinuing azathioprine were side‐effects (13 patients), failure of efficacy (four patients) and leucopenia (two patients). Eleven of the 19 patients (68%) tolerated 6‐mercaptopurine, including seven out of 13 patients (54%) who discontinued azathioprine due to side‐effects. The length of follow‐up of patients on 6‐mercaptopurine was between 126 and 780 days (median 390 days).Discussion:6‐mercaptopurine should be considered in patients with inflammatory bowel disease who require continuing immunosuppressive therapy, but are intolerant of azathioprine.

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