[논문]Relationship between microfilaria count and sensitivity of the direct smear for diagnosis of canine dirofilariosis

Courtney, Charles H; Zeng, Qi-Yun

doi:10.1016/s0304-4017(00)00377-0

[해외논문] Relationship between microfilaria count and sensitivity of the direct smear for diagnosis of canine dirofilariosis

Veterinary parasitology, v.94 no.3, 2001년, pp.199 - 204

Courtney, Charles H (Corresponding author. Tel.: +1-352-392-4700) , Zeng, Qi-Yun (fax: +1-352-392-8351)

Abstract ▼ AI-Helper

AbstractDirect blood smear examination (using 0.05ml of whole blood) detected 168 (80.9%) of 204 microfilaremic canine blood samples as determined by the modified Knott test for microfilariae (mff) of Dirofilaria immitis (using 1ml of whole blood). Direct smear examination detected all of 134 microfilaremias greater than 50mffml−1, but only 31 of 70 (44.3%) microfilaremias having less than 50mffml−1. In a separate retrospective query of a database of 963 dogs with necropsy-confirmed heartworm infections, 834 (86.6%) were positive by the DiroCHEK heartworm antigen test, and 504 (52.3%) were microfilaremic by the modified Knott test. Only 2 (0.4%) of the microfilaremic dogs were DiroCHEK negative and another 18 (3.6%) were very weak positives. Although these microfilaremic dogs were not tested by direct smear, only one of the two DiroCHEK-negative and six of 18 weakly DiroCHEK-positive dogs had microfilaremias so low that a direct smear may have given a false negative result. Significant adverse reactions to either diethylcarbamazine or the macrolide endectocides have not been reported for microfilaremias less than 500mffml−1, thus substitution of the direct smear for a concentration test for mff, such as the modified Knott test or membrane filtration, does not appear to increase the risk of an unexpected adverse reaction to heartworm prophylactic drugs. Such a substitution results in only a very slight decrease (on the order of 0.1%) in the overall sensitivity of heartworm screening, provided a test for mff is run concurrently with an antigen test. If a test for mff is the only screening test used, then substitution of a direct smear for a concentration test may decrease the sensitivity of heartworm screening by nearly 20%, depending on the prevalence of low level microfilaremias in the population of dogs tested.

주제어

참고문헌 (9)

American Heartworm Society, 1993. Recommended procedures for the diagnosis and management of heartworm (Dirofilaria immitis) infection. In: Soll, M.D. (Ed.), Proceedings of the Heartworm Symposium ’92, American Heartworm Society, Batavia, IL, pp. 289-294.
Blagburn, B.L., Hendrix, C.M., Lindsay, D.S., Vaughan, J.L., Hepler, D.I., 1993. Post-adulticide milbemycin oxime microfilaricidal activity in dogs naturally infected with Dirofilaria immitis. In: Soll, M.D. (Ed.), Proceedings of the Heartworm Symposium ’92, American Heartworm Society, Batavia, IL, pp. 159-164.
Int. J. Parasitol. Boreham 13 547 1983 10.1016/S0020-7519(83)80026-5 Adverse drug reactions in the treatment of filarial parasites: haematological, biochemical, immunological and pharmacological changes in Dirofilaria immitis infected dogs treated with diethylcarbamazine

상세보기
Courtney, C.H., Zeng, Q.-Y., 1989. The structure of heartworm populations in dogstpandtpcats in Florida. In: Otto, G.F. (Ed.), Proceedings of the Heartworm Symposium ’89, American Heartworm Society, Washington, DC, pp. 1-6.
Courtney, C.H., Zeng, Q.-Y., Maler, M.M., 1999. The effect of chronic administration of milbemycin oxime and ivermectin on microfilaremias in heartworm-infected dogs. In: Seward, R.L., Knight, D.H. (Eds.), Proceedings of the Recent Advances in Heartworm Disease: Symposium ’98, American Heartworm Society, Batavia, IL, pp. 193-199.
Jackson, R.F., Otto, G.F., 1975. Detection and differentiation of microfilariae. In: Otto, G.F. (Ed.), Proceedings of the Heartworm Symposium ’74. VM Publishing, Inc., Bonner Springs, KS, pp. 21-22.
Jackson, R.F., Seymour, W.G., 1981. Efficacy of avermectins against microfilariae of Dirofilaria immitis. In: Otto, G.F. (Ed.), Proceedings of the Heartworm Symposium ’80. VM Publishing, Inc., Edwardsville KS, pp. 131-126.
Jackson, R.F., Seymour, W.G., Beckett, R.S., 1986. Lower dose of ivermectin as a microfilaricide, 0.05 mg kg？1. In: Otto, G.F. (Ed.), Proceedings of the Heartworm Symposium ’86, American Heartworm Society, Washington, DC, pp.15-18.
Tropenmed. Parasitol. Palumbo 32 115 1981 Observations on the adverse reaction to diethylcarbamazine in Dirofilaria immitis-infected dogs

상세보기

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 논문명, 저널/프로시딩명, 저자 , 발행년, 권, 호, 시작페이지, 끝페이지, 발행기관 관리번호, 논문명, 대등논문명, 저자 , 저널/프로시딩명, 발행기관, 발행년, 발행언어, 권, 호, 시작페이지, 끝페이지, ISBN, ISSN, 주제분야, 키워드, 초록(한글), 초록(영문), 저자(소속기관)
저장형식	Text(ASCII format) Excel format RefWorks Direct Export RIS format (for Reference Manager, ProCite, EndNote), Scholar's Aids, Mendeley
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

[해외논문] Relationship between microfilaria count and sensitivity of the direct smear for diagnosis of canine dirofilariosis

Abstract ▼ AI-Helper

주제어

참고문헌 (9)

이 논문을 인용한 문헌

관련 콘텐츠

원문 URL 링크

연관된 기능

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트