[논문]Kinetic parameters of calcium currents in maturing acutely isolated CA1 cells

Ribeiro, Maria Alexandra; Costa, Pedro Freire

doi:10.1016/S0165-3806(00)00099-7

[해외논문] Kinetic parameters of calcium currents in maturing acutely isolated CA1 cells

Brain research, Developmental brain research, v.124 no.1/2, 2000년, pp.11 - 23

Ribeiro, Maria Alexandra (Departamento de Fisiologia, Faculdade de Ciê) , Costa, Pedro Freire (ncias Mé)

Abstract ▼ AI-Helper

AbstractCalcium currents were recorded in CA1 hippocampal cells from immature (P4–10) and older (P22–55) rats, using whole-cell voltage clamp techniques. Parameters defining the voltage-dependence of activation (τm) and inactivation (τh), steady-state inactivation and activation were determined at both stages of maturation. Current density increased with maturation. A transient low voltage activated (l.v.a.) current was found in P4–10 cells, but not in the older cells. At voltages less negative than −30 mV, current inactivation was best described by two exponentials (τhf,τhs); the ratio of the amplitudes of the two components changed with maturation, with a dominance of the faster component (τhf) in the younger cells. The voltage dependence of τhf followed a simple dependence model, decreased with increasing depolarization, in all cells at both stages of maturation. In P4–10 cells, τhs was voltage insensitive (range −25 to +30 mV); in P22–55 cells, the voltage dependence of τhs was found to be complex. Two current components were identified from the voltage dependence of the conductance in both groups. The first, more hyperpolarized component, the l.v.a. current found in P4–10 cells; this was absent in the older cells, in which we found a component with a different voltage dependence. The voltage dependence of the conductance of the second, more depolarized component did not differ in younger and older cells. In the course of maturation, the steady-state inactivation of the second component underwent a hyperpolarizing shift and a decrease in voltage sensitivity.

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