[논문]Regulation of rat hippocampal neural cadherin in the kainic acid induced seizures

doi:10.1016/S0304-3940(00)01635-9

[해외논문] Regulation of rat hippocampal neural cadherin in the kainic acid induced seizures

Neuroscience letters, v.297 no.1, 2001년, pp.13 - 16

Fujita, Masataka (Department of Neurosurgery, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467–) , Aihara, Noritaka (8601, Japan) , Yamamoto, Manami (Department of Neurosurgery, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467–) , Ueki, Takatoshi (8601, Japan) , Asai, Kiyofumi (Department of Bioregulation Research, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467–) , Tada, Toyohiro (8601, Japan) , Kato, Taiji (Department of Bioregulation Research, Nagoya City University Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467–) , Yamada, Kazuo (8601, Japan)

Abstract ▼ AI-Helper

AbstractRegulation of neural (N-) cadherin expression in the hippocampus was examined by in situ hybridization and immunohistochemistry methods in the rat model of kainic acid (KA) induced seizures. After 12 and 24 h of KA administration, mRNA expression level of N-cadherin decreased in the hippocampal CA1 and CA3 area in parallel with decrease of the number of neural cells. In contrast, after 48 h and 7 days, mRNA expression level recovered partially, although the number of neural cells remained small. In addition, immunohistochemical staining indicated that N-cadherin protein expression of survived neurons increased significantly after 48 h of KA administration. These results indicated that N-cadherin might be involved in neuronal reconstruction at the hippocampus.

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