[논문]Low and infrequent expression of nitric oxide synthase/NADPH-diaphorase in neurons of the human supraoptic nucleus: a histochemical study

doi:10.1016/S0891-0618(00)00087-9

[해외논문] Low and infrequent expression of nitric oxide synthase/NADPH-diaphorase in neurons of the human supraoptic nucleus: a histochemical study

Journal of chemical neuroanatomy, v.20 no.2, 2000년, pp.177 - 183

Bernstein, H.-G (Department of Psychiatry, Otto v. Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany) , Jirikowski, G.F (Institute of Anatomy II, Friedrich Schiller University, Jena, Germany) , Heinemann, A (Department of Psychiatry, Otto v. Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany) , Baumann, B (Department of Psychiatry, Otto v. Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany) , Hornstein, Ch (Department of General Psychiatry, Center North Baden at Wiesloch, Wiesloch, Germany) , Danos, P (Department of Psychiatry, Otto v. Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany) , Diekmann, S (Department of Psychiatry, Otto v. Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany) , Sauer, H (Department of Psychiatry, Friedrich Schiller University, Jena Germany) , Keilhoff, G (Institute of Medical Neurobiology, University of Magdeburg, Magdeburg, Germany) , Bogerts, B (Department of Psychiatry, Otto v. Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany)

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AbstractThe gas nitric oxide is a messenger in brain signaling. In the hypothalamo–hypophyseal system nitric oxide is involved in the control of the expression and/or release of peptide hormones (corticotropin-releasing hormone, gonadotropin-releasing hormone, vasopressin and oxytocin). Nitric oxide synthase (NOS), the enzyme generating nitric oxide, is abundantly present in the magnocellular nuclei of the rat hypothalamus. Its localization in the human hypothalamus is less well studied. Hence, we investigated the anatomical distribution of neuronal nitric oxide synthase in the human supraoptic nucleus by use of immunohistochemical and enzyme histochemical techniques. The immunohistochemical localization of NOS was studied in 31 matched human hypothalami (13 control cases, eight depressed patients and ten schizophrenics). NADPH-diaphorase studies were carried out on seven additional hypothalami (three normal brains, four schizophrenics). Apparent inter-individual differences exist with regard to the occurrence of the enzyme in supraoptic neurons. In a majority of cases no immunostaining or histochemical reaction for the enzyme was observed. In seven cases (three controls, two schizophrenics, two depressives) a population of nitrergic nerve cells was seen in the dorsomedial part of the nucleus. This group of cells also stained for NADPH-diaphorase. Also, there were a few NOS-immunopositive neurons scattered throughout the nucleus. Additionally, thin NADPH-diaphorase positive fibers were observed to cross the nucleus. Our data show that, unlike the rat, the human supraoptic nucleus contains only a small number of nitrergic neurons. No correlation was found between the expression of the enzyme in supraoptic neurons and the psychiatric status of the patients.

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참고문헌 (31)

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[해외논문] Low and infrequent expression of nitric oxide synthase/NADPH-diaphorase in neurons of the human supraoptic nucleus: a histochemical study

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참고문헌 (31)

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