[논문]Laryngeal cytological aspects in women with surgically induced menopause who were treated with transdermal estrogen replacement therapy

doi:10.1016/S0015-0282(00)01582-X

[해외논문] Laryngeal cytological aspects in women with surgically induced menopause who were treated with transdermal estrogen replacement therapy 원문보기

Fertility and sterility, v.74 no.6, 2000년, pp.1073 - 1079

Caruso, Salvatore (Research Group for Sexology, Department of Microbiological Science and Gynecological Science, University of Catania, Catania, Italy) , Roccasalva, Lucia (Service for Menopause, Department of Microbiological Science and Gynecological Science, University of Catania, Catania, Italy) , Sapienza, Gloria (Research Group for Sexology, Department of Microbiological Science and Gynecological Science, University of Catania, Catania, Italy) , Zappalá, Maria (Department of Otorhinolaryngology, University of Catania, Catania, Italy) , Nuciforo, Giuseppe (Service of Pathological Anatomy, “) , Biondi, Salvatore (S. Bambino”)

Abstract ▼ AI-Helper

AbstractObjective: To investigate the effects of estrogen replacement therapy (ERT) on laryngeal cytology in postmenopausal women.Design: Prospective open clinical trial.Setting: Outpatient menopausal clinic in the Department of Gynecology, University of Catania, Catania, Italy.Patient(s): Eighty-four healthy, surgically postmenopausal women, of whom 48 were treated with ERT and 36 were considered as a control group.Intervention(s): Transdermal E2 treatment by patches or gel, evaluation of laryngeal cytology with cytobrush by indirect laryngoscopy, and questionnaire for the voice history.Main Outcome Measure(s): Changes in cytologic aspects of laryngeal cells with respect to vaginal cytology by hematoxylin and eosin staining; subjective voice changes.Result(s): Sixty-seven women completed the study. Ten women from the ERT group and five from the control group dropped out because of the invasive laryngoscope method; two subjects in the control group were excluded because of pathologies of the vocal cord. Hematoxylin and eosin staining confirmed similar superficial-intermediate aspects of the cells between the laryngeal and the vaginal smears in ERT-treated women. In the control group, both smears showed aspects of atrophy-dystrophy. The ERT group had a subjectively better quality of voice than the control group.Conclusion(s): Our study confirms that the larynx is an estrogen target, as are vaginal cells. ERT may provide prevention and treatment of dystrophic pathologies of the vocal cords in postmenopausal women.

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